scholarly journals QOLP-13. IMPACT OF CANNABIS USE ON QUALITY OF LIFE IN PATIENTS WITH CENTRAL NERVOUS SYSTEM TUMORS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi200-vi200
Author(s):  
Eduardo Rodriguez Almaraz ◽  
Nicholas Butowski ◽  
Susan Chang ◽  
Nancy Ann Oberheim-Bush ◽  
Jennifer Clarke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Cannabis Use ◽  
Primary Brain Tumors ◽  
Potential Benefits ◽  
The Mean ◽  
The Difference ◽  
Validated Instrument ◽  
Single Center Observational Study

Abstract BACKGROUND Nearly 80,000 new cases of primary brain tumors are expected to be diagnosed this year, 32% of CNS tumors are malignant. Anecdotally, patients who report use of cannabis, frequently describe higher quality of life scores (QOL) in standardized instruments. However, the lack of available tools that allow systematic documentation of cannabis use results in a barrier to accurately assess efficacy, potential benefits and risks. METHODS We conducted a single center, observational study: patients with primary brain tumors answered a previously validated instrument to explore cannabis use. QOL was assessed using the instruments from the European Organisation for Research and Treatment of Cancer: QLQ-C30 and its complementary module BN-20 as well as the EuroQol instrument EQ-5D-5L. Eligible participants were identified as cannabis users or non-users, completing the instruments in a self-administered fashion. RESULTS To date, 51 patients who signed informed consent were enrolled and answered the questionnaires, mean age was 51 (SD 12.95) years, 34 were male, 30 were considered active cannabis users (66.6% males and 33.3% females). The mean global health score in the QLQ-C30 instrument was 68.4 (SD: 20.7) among cannabis users and 82.2 (SD: 17.5) among non-users. The mean difference in QOL scores between users and non-users was 13.8 (95%CI: 2.8, 24.8; p=0.01). In contrast the difference between cannabis users and non-users in QOL index in the EQ-5D-5L instrument was 0.13 (95% CI: 0.06, 0.2; p=0.001). Among cannabis users, patients perceive their symptoms as moderate before using cannabis and mild after using cannabis (p >0.001) CONCLUSIONS In our analysis, patients who use cannabis reported, on average, lower QOL scores. Potentially, sicker patients resort to cannabis to improve their symptoms and ultimately quality of life. The perception of patients is that cannabis usage improves overall quality of life. Findings provide support to perform prospective studies.

scholarly journals P08.01 Impact of cannabis use on quality of life in patients with central nervous system tumors

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii37-iii37
Author(s):  
J E Rodriguez Almaraz ◽  
N A Butowski ◽  
S M Chang ◽  
N A E Oberheim-Bush ◽  
J R Clarke ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Global Health ◽  
Cannabis Use ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors ◽  
The Mean

Abstract BACKGROUND Nearly 80,000 new cases of primary brain tumors are expected to be diagnosed this year in the United States: 32% of CNS tumors are malignant. Anecdotally, patients who report use of cannabis, frequently describe higher quality of life scores (QOL) in standardized instruments. However, the lack of available tools that allow systematic documentation of cannabis use results in a barrier to accurately assess efficacy and potential benefits and risks. MATERIAL AND METHODS We conducted a single center, observational study: patients with primary brain tumors answered a previously validated instrument to explore cannabis use. QOL was assessed using the instruments from the European Organisation for Research and Treatment of Cancer(EORTC): QLQ-C30 and its complementary module BN-20 as well as the EuroQol group’s instrument EQ-5D-5L. Eligible participants were identified as cannabis users or non-users, completing the instruments in a self-administered fashion. RESULTS To date, 45 patients who signed informed consent were enrolled and answered the questionnaires, mean age was 51 (SD 13.5) years, 31 were male, 25 were considered active cannabis users (624% males and 36% females). At baseline, the mean Global Health score in the QLQ-C30 instrument was 68.6 (SD: 20.6) among cannabis users and 82 (SD: 18.05) among non-users. The mean difference in Global Health QOL scores between users and non-users was 13.35 (95%CI: 1.34, 25.35; p=0.03). In contrast the difference between cannabis users and non-users in QOL index in the EQ-5D-5L instrument was 0.13 (0.77 vs 0.91; p=0.002). Among cannabis users, patients perceive their symptoms as moderate before using cannabis and mild after using cannabis (p>0.001). CONCLUSION In our analysis, patients who use cannabis have, on average, lower QOL scores signaling that sicker patients resort to cannabis to improve their symptoms and ultimately their quality of life. Patients’ perception is one of improvement in the overall quality of life when using cannabis. Our findings provide background support to perform prospective studies in the impact of cannabis in quality of life of patients with central nervous system tumors.

scholarly journals Psychiatric and cognitive correlates of quality of life among persons with primary brain tumors

2019 ◽  
Vol 28 (1) ◽  
pp. 141 ◽  
Author(s):  
Shruti Srivastava ◽  
ManjeetS Bhatia ◽  
Aman Gaur ◽  
Gurubachan Singh
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Primary Brain Tumors ◽  
Cognitive Correlates

scholarly journals Correlation Between Stigma and Quality of Life in Leprosy Patients in Mehrab Khan Region of Mashhad

2021 ◽  
Author(s):  
Zahra Safavi Bayat ◽  
Wim Van Brakel ◽  
Hamideh Ebrahimi ◽  
Nadere Naderi Ravesh ◽  
Nezhat Shakeri ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pearson Correlation ◽  
Inverse Correlation ◽  
Cross Sectional Study ◽  
Social Dimension ◽  
Cross Sectional ◽  
Psychological Dimension ◽  
The Mean ◽  
The Difference

Leprosy is one of the oldest chronic diseases, and similar to other infectious diseases, it causes long-term physical and social effects on the lives of patients and their families. This was a cross-sectional study conducted with 103 patients with leprosy in Mashhad in the Mehrab Khan region in March 2016. The sampling method was convenience sampling. The data was analyzed using SPSS version 19. Descriptive statistics (frequency, percentage, mean and standard deviation) and inferential tests (ANOVA, Pearson correlation, and independent t-test) were used. The results showed that the mean age of patients was 65.2±8.1 years and the mean age of developing leprosy was 15.3±7.03. There was an inverse correlation between the score of overall stigma, internal stigma, and all dimensions of quality of life that was statistically significant, except for the social dimension (r= -0.181…; P=0.067). There was an inverse correlation between the psychological dimension of quality of life and experienced stigma. The highest score of the overall quality of life was related to divorced patients with a mean score of 79.7, which was statistically significant (P=0.016) from those who were not divorced. In post-hoc test, just the difference between widow and divorced were significant regarding quality of life. According to results, there was a negative correlation between the quality of life and all aspects of stigma using the SARI tool.

scholarly journals Translation and validation of the Urdu version of the European organization for research and treatment of cancer core quality of life questionnaire (EORTC QLQ-C30) and brain module (QLQ-BN20) in primary brain tumor patients

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Nida Zahid ◽  
Russell Seth Martins ◽  
Wajeeha Zahid ◽  
Wardah Khalid ◽  
Iqbal Azam ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Tertiary Care ◽  
Life Questionnaire ◽  
Care Hospital ◽  
European Organization ◽  
Primary Brain Tumors ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Abstract Introduction This study translated and validated the Urdu version of the European Organization for Research and Treatment of Cancer Quality of Life (QoL) Questionnaire (EORTC QLQ-C30) and Brain Module (QLQ-BN20) amongst patients with primary brain tumors (PBT) in Pakistan, and assessed the correlation of QoL with resilience, depression, and anxiety. Methods Translation of the EORTC QLQ-C30 and QLQ-BN20 was performed as per EORTC guidelines. A survey comprising of Urdu translations of EORTC QLQ-C30, QLQ-BN20, Wagnild and Young Resilience Scale (RS-14) and Hospital Anxiety and Depression Scale was administered to patients with PBT at a tertiary care hospital in Pakistan. Reliability (via Cronbach alpha), content validity index (CVI) scores, construct validity, and inter-scale correlations were assessed. Results Our sample consisted of 250 patients with PBT, most commonly glioma (46.8%) and meningioma (21.2%). All patients were able to understand the Urdu translations. The Cronbach alphas for the QLQ-C30 and the QLQ-BN20 were 0.860 and 0.880, respectively. The CVI scores for clarity and relevance were high for both the EORTC QLQ-C30 (0.98 and 0.96, respectively) and the QLQ-BN20 tool (0.81 and 0.95, respectively). The global QoL domain (EORTC QLQ-C30) showed significant positive correlations with resilience (r = 0.422), and significant negative correlations with depression (r =  − 0.541) and anxiety (r =  − 0.502). Strong inter-scale correlations were observed between physical functioning and insomnia (r =  − 0.690) and role functioning and insomnia (r =  − 0.641). Conclusion Our study confirms the Urdu versions of the EORTC QLQ-C30 and QLQ-BN20 as valid clinical tools for the measurement of QoL in primary brain tumors patients within the cultural and socioeconomic context of Pakistan.

Factors influencing quality of life in patients with benign primary brain tumors: prior to and following surgery

2010 ◽  
Vol 20 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Shiow-Luan Tsay ◽  
Jui-Yen Chang ◽  
Patsy Yates ◽  
Kuan-Chia Lin ◽  
Shu-Yuan Liang
Keyword(s):  
Quality Of Life ◽  
Brain Tumors ◽  
Primary Brain Tumors ◽  
Factors Influencing
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