scholarly journals Disparities in Integrase Inhibitor Usage in the Modern HIV Treatment Era: a Population-Based Study in a U.S. City

2021 ◽  
Author(s):  
Matthew A Spinelli ◽  
Nancy A Hessol ◽  
Sandra K Schwarcz ◽  
Susan Scheer ◽  
Monica Gandhi ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
San Francisco ◽  
Integrase Inhibitor ◽  
Population Based ◽  
Hiv Treatment ◽  
People Living With Hiv ◽  
Population Based Study ◽  
Factors Associated ◽  
Living With Hiv

Abstract Integrase inhibitor-based (INSTI) antiretroviral therapy (ART) regimens are preferred for most people living with HIV (PLWH). We examined factors associated with INSTI use among PLWH in San Francisco who started ART in 2009-2016. PLWH who experienced homelessness were less likely, and older PLWH were more likely, to use an INSTI.

scholarly journals Quality of life among people living with HIV in England and the Netherlands: a population-based study

2021 ◽  
Vol 8 ◽  
pp. 100177
Author(s):  
Stephanie Popping ◽  
Meaghan Kall ◽  
Brooke E. Nichols ◽  
Evelien Stempher ◽  
Lisbeth Versteegh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
The Netherlands ◽  
Population Based ◽  
People Living With Hiv ◽  
Population Based Study ◽  
Living With Hiv

A model to predict adherence to antiretroviral therapy among people living with HIV

2021 ◽  
pp. sextrans-2021-055222
Author(s):  
Hui Chen ◽  
Rusi Long ◽  
Tian Hu ◽  
Yaqi Chen ◽  
Rongxi Wang ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Treatment ◽  
Poor Adherence ◽  
People Living With Hiv ◽  
Art Adherence ◽  
Snowball Sampling ◽  
Hiv Viral Load ◽  
Temporal Validation ◽  
Suboptimal Adherence ◽  
Living With Hiv

ObjectivesSuboptimal adherence to antiretroviral therapy (ART) dramatically hampers the achievement of the UNAIDS HIV treatment targets. This study aimed to develop a theory-informed predictive model for ART adherence based on data from Chinese.MethodsA cross-sectional study was conducted in Shenzhen, China, in December 2020. Participants were recruited through snowball sampling, completing a survey that included sociodemographic characteristics, HIV clinical information, Information-Motivation-Behavioural Skills (IMB) constructs and adherence to ART. CD4 counts and HIV viral load were extracted from medical records. A model to predict ART adherence was developed from a multivariable logistic regression with significant predictors selected by Least Absolute Shrinkage and Selection Operator (LASSO) regression. To evaluate the performance of the model, we tested the discriminatory capacity using the concordance index (C-index) and calibration accuracy using the Hosmer and Lemeshow test.ResultsThe average age of the 651 people living with HIV (PLHIV) in the training group was 34.1±8.4 years, with 20.1% reporting suboptimal adherence. The mean age of the 276 PLHIV in the validation group was 33.9±8.2 years, and the prevalence of poor adherence was 22.1%. The suboptimal adherence model incorporates five predictors: education level, alcohol use, side effects, objective abilities and self-efficacy. Constructed by those predictors, the model showed a C-index of 0.739 (95% CI 0.703 to 0.772) in internal validation, which was confirmed be 0.717 via bootstrapping validation and remained modest in temporal validation (C-index 0.676). The calibration capacity was acceptable both in the training and in the validation groups (p>0.05).ConclusionsOur model accurately estimates ART adherence behaviours. The prediction tool can help identify individuals at greater risk for poor adherence and guide tailored interventions to optimise adherence.

Polypharmacy and Drug–Drug Interactions in People Living With Human Immunodeficiency Virus in the Region of Madrid, Spain: A Population-Based Study

2019 ◽  
Vol 71 (2) ◽  
pp. 353-362 ◽  
Author(s):  
Beatriz López-Centeno ◽  
Carlos Badenes-Olmedo ◽  
Ángel Mataix-Sanjuan ◽  
Katie McAllister ◽  
José M Bellón ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Interactions ◽  
Age Groups ◽  
Population Based ◽  
People Living With Hiv ◽  
Traffic Light ◽  
Population Based Study ◽  
Immunodeficiency Virus ◽  
Red Flag ◽  
Living With Hiv

Abstract Background Drug–drug interactions (DDIs) that involve antiretrovirals (ARVs) tend to cause harm if unrecognized, especially in the context of comorbidity and polypharmacy. Methods A linkage was established between the drug dispensing registry of Madrid and the Liverpool human immunodeficiency virus (HIV) DDI database (January 2017–June 2017). Polypharmacy was defined as the use of ≥5 non-HIV medications, and DDIs were classified by a traffic-light ranking for severity. Results A total of 22 945 people living with HIV (PLWH) and 6 613 506 individuals without HIV had received medications. ARV regimens were predominantly based on integrase inhibitors (51.96%). Polypharmacy was higher in PLWH (32.94%) than individuals without HIV (22.16%; P < .001); this difference was consistently observed across all age strata except for individuals ≥75 years. Polypharmacy was more common in women than men in both PLWH and individuals without HIV. The prevalence of contraindicated combinations involving ARVs was 3.18%. Comedications containing corticosteroids, quetiapine, or antithrombotic agents were associated with the highest risk for red-flag DDI, and the use of raltegravir- or dolutegravir-based antiretroviral therapy was associated with an adjusted odds ratio of 0.72 (95% confidence interval, .60–.88; P = .001) for red-flag DDI. Conclusions Polypharmacy was more frequent among PLWH across all age groups except those aged ≥75 years and was more common in women. The detection of contraindicated medications in PLWH suggests a likely disconnect between hospital and community prescriptions. Switching to alternative unboosted integrase regimens should be considered for patients with risk of harm from DDIs.

scholarly journals Prevalence and factors associated with hypertension among people living with HIV/AIDS on antiretroviral therapy in Uganda

2021 ◽  
Vol 38 ◽  
Author(s):  
Gloria Lubega ◽  
Billy Mayanja ◽  
Joseph Lutaakome ◽  
Andrew Abaasa ◽  
Rebecca Thomson ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Factors Associated ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS

2020 ◽  
Vol 24 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Larissa Negromonte Azevedo ◽  
Ricardo Arraes de Alencar Ximenes ◽  
Polyana Monteiro ◽  
Ulisses Ramos Montarroyos ◽  
Demócrito de Barros Miranda-Filho
Keyword(s):  
Antiretroviral Therapy ◽  
Adverse Events ◽  
People Living With Hiv ◽  
First Line ◽  
Factors Associated ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Social support status and associated factors among people living with HIV/AIDS in Kunming city, China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi Li ◽  
Xiao-Wen Zhang ◽  
Bin Liao ◽  
Jun Liang ◽  
Wen-Jie He ◽  
...  
Keyword(s):  
Social Support ◽  
Antiretroviral Therapy ◽  
Associated Factors ◽  
Support Network ◽  
People Living With Hiv ◽  
Monthly Income ◽  
Factors Associated ◽  
The Social ◽  
Living With Hiv ◽  
Hiv Aids

Abstract Background People living with HIV/AIDS not only require effective treatment for the alleviation of physical discomfort but also require social support to help them address difficulties in life and relieve their psychological anxiety and uneasiness. The social support network is of tremendous importance in helping people living with HIV/AIDS maintain good physical and mental health. This study aims to analyse the social support status among people living with HIV/AIDS in Kunming and explore associated factors. Method The Social Support Rating Scale (SSRS) was used, and a questionnaire survey was conducted using convenience sampling to select people living with HIV/AIDS from 14 counties of Kunming. It collected information on general demographic information and social support status. Univariate and multivariate linear regression models were used to explore the associated factors. Results A total of 990 valid questionnaires were completed. Data from all participants were analysed. Univariate analysis suggested that the factors associated with social support may include marital status, monthly income, and antiretroviral therapy. On the other hand, factors including monthly income and antiretroviral therapy accounted for the social support total score in the multivariate analysis. Conclusion Social support among people living with HIV/AIDS in Kunming was generally low. This study identified a number of factors associated with social support among people living with HIV/AIDS. Based on our findings, appropriate interventions should be introduced to provide social support for those living with HIV/AIDS.

Sign in / Sign up

Export Citation Format

Share Document