scholarly journals Coxiella burnetii Infection Associated with Thromboangiitis Obliterans-like Phenomena with Digital Auto-amputation: A Case Report and Review of Q fever Associated Autoimmunity

2021 ◽  
Author(s):  
Zachary Shepard ◽  
Tara Skorupa ◽  
Leigh Espinoza ◽  
Kristine Erlandson ◽  
Laura Damioli
Keyword(s):  
Case Report ◽  
Autoimmune Diseases ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Thromboangiitis Obliterans ◽  
Chronic Q Fever ◽  
Digital Necrosis ◽  
Autoimmune Phenomena ◽  
New Onset

Abstract We present a case of a patient with chronic Q fever who presented with digital necrosis, auto-amputations, and positive anti-centromere antibody, mimicking a scleroderma vasculopathy or thromboangiitis obliterans. Coxiella burnetii infection has long been associated with the presence of auto-antibodies and autoimmune phenomena including vasculitis. Clinicians should consider Q fever testing in patients with new onset autoimmune diseases or auto-antibodies and appropriate exposure histories.

scholarly journals A fatal case of disseminated chronic Q fever: a case report and brief review of the literature

Infection ◽  
2016 ◽  
Vol 44 (5) ◽  
pp. 677-682 ◽  
Author(s):  
Stephan P. Keijmel ◽  
Ruud P. H. Raijmakers ◽  
Teske Schoffelen ◽  
Maria C. W. Salet ◽  
Chantal P. Bleeker-Rovers
Keyword(s):  
Case Report ◽  
Q Fever ◽  
Fatal Case ◽  
Review Of The Literature ◽  
Chronic Q Fever

scholarly journals A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever

2014 ◽  
Vol 20 (7) ◽  
pp. 642-650 ◽  
Author(s):  
T. Schoffelen ◽  
T. Sprong ◽  
C.P. Bleeker-Rovers ◽  
M.C.A. Wegdam-Blans ◽  
A. Ammerdorffer ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Interleukin 2 ◽  
Circulating Cells ◽  
Chronic Q Fever

scholarly journals Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Zanthia Wiley ◽  
Sujan Reddy ◽  
Kara M. Jacobs Slifka ◽  
David C. Brandon ◽  
John Jernigan ◽  
...  
Keyword(s):  
United States ◽  
Abdominal Pain ◽  
Aortic Aneurysm ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Antibody Detection ◽  
Vascular Involvement ◽  
Chronic Q Fever ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair

Q fever is a zoonotic bacterial infection caused by Coxiella burnetii. Chronic Q fever comprises less than five percent of all Q fever cases and, of those, endocarditis is the most common presentation (up to 78% of cases), followed by vascular involvement. Risk factors for chronic Q fever with vascular involvement include previous vascular surgery, preexisting valvular defects, aneurysms, and vascular prostheses. The most common symptoms of chronic Q fever with vascular involvement are nonspecific, including weight loss, fatigue, and abdominal pain. Criteria for diagnosis of chronic Q fever include clinical evidence of infection and laboratory criteria (antibody detection, detection of Coxiella burnetii DNA, or growth in culture). Treatment of chronic Q fever with vascular involvement includes a prolonged course of doxycycline and hydroxychloroquine (≥18 months) as well as early surgical intervention, which has been shown to improve survival. Mortality is high in untreated chronic Q fever. We report a case of chronic Q fever with vascular involvement in a 77-year-old man with prior infrarenal aortic aneurysm repair, who lived near a livestock farm in the southeastern United States.

Psoas abscess and chronic Q fever: a contiguous or hematogenous complication? A case report and literature review

2016 ◽  
Vol 48 (8) ◽  
pp. 626-631 ◽  
Author(s):  
Adrien Galy ◽  
Jean Winoc Decousser ◽  
Sarra El-Anbassi ◽  
Biba Nebbad ◽  
Carine Belzunce ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Q Fever ◽  
Psoas Abscess ◽  
Chronic Q Fever

scholarly journals Animals withCoxiella burnetiiInfection Demonstrate a Western Immunoblot Profile of Chronic Q Fever in Humans

1996 ◽  
Vol 7 (1) ◽  
pp. 45-48
Author(s):  
TJ Marrie ◽  
Linda Yates
Keyword(s):  
Immune Response ◽  
Phase I ◽  
Phase Ii ◽  
Coxiella Burnetii ◽  
Q Fever ◽  
Western Immunoblotting ◽  
Western Immunoblot ◽  
Chronic Q Fever

Western immunoblotting was used to compare the immune response toCoxiella burnetiiphase I and phase II antigens of humans with acute and chronic Q fever with that of infected cats, rabbits, cows and raccoons. The cats, rabbits, cows and raccoons had an immunoblot profile similar to that of the human with chronic Q fever.

scholarly journals Chronic Q Fever with No Elevation of Inflammatory Markers: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Matteo Boattini ◽  
André Almeida ◽  
Rita Barata Moura ◽  
João Abreu ◽  
Ana Sofia Santos ◽  
...  
Keyword(s):  
Case Report ◽  
Aortic Valve ◽  
Liver Biopsy ◽  
Literature Review ◽  
Inflammatory Markers ◽  
Q Fever ◽  
Infectious Hepatitis ◽  
Prosthetic Aortic Valve ◽  
Chronic Q Fever ◽  
Night Sweats

We describe the case of a 55-year-old man with a biological prosthetic aortic valve who suffered from epigastrium and right hypochondrium pain associated with intermittent night sweats. Liver biopsy showed infectious hepatitis pattern without pathognomonic features.Coxiella burnetiiserology was suggestive of chronic Q fever, and modified Duke's criteria for endocarditis were also fulfilled. The authors present a brief literature review concerning chronic Q fever, emphasizing absent previous reports of chronic Q fever with hepatitis and endocarditis and no increase in inflammatory markers.

Q-fever presenting as an autoimmune disease: case report and review

Open Medicine ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. 727-731 ◽  
Author(s):  
Maria Gamaletsou ◽  
Achilleas Gikas ◽  
Nikolaos Sipsas
Keyword(s):  
Autoimmune Disease ◽  
Monoclonal Gammopathy ◽  
Erythema Nodosum ◽  
Q Fever ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Laboratory Findings ◽  
Chronic Q Fever ◽  
Disease Case ◽  
Antibodies Monoclonal ◽  
Autoimmune Phenomena

AbstractQ fever is a worldwide zoonosis caused by the intracellular bacterium Coxiella burnetti. Autoimmune phenomena associated with the disease may obscure the clinical picture, and in many reports mislead physicians to an initial diagnosis of an autoimmune disease. We present a case of chronic Q-fever, complicated by myocarditis/pericarditis, where patient’s initial signs, symptoms and laboratory findings (i.e., protracted fever, oligoarthritis, erythema nodosum, positive antineutrophil cytoplasmic antibodies, monoclonal gammopathy) seemed to suggest an autoimmune disease. We also review the literature for autoimmune phenomena associated with Q-fever.

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