scholarly journals 2406. “Real-world” Treatment of Multidrug-Resistant (MDR) or Extensively Drug-Resistant (XDR) P. aeruginosa Infections With Ceftolozane/Tazobactam (C/T) vs. a Polymyxin or Aminoglycoside (Poly/AG)-based Regimen: A Multicenter Comparative Effectiveness Study

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S719-S719 ◽  
Author(s):  
Jason M Pogue ◽  
Keith S Kaye ◽  
Michael Veve ◽  
Anthony Gerlach ◽  
Twisha S Patel ◽  
...  
Keyword(s):  
Real World ◽  
Comparative Effectiveness ◽  
Multidrug Resistant ◽  
Effectiveness Study ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Comparative Effectiveness Study

scholarly journals AB0373 A COMPARATIVE EFFECTIVENESS STUDY OF ABATACEPT AND TNFI AGENTS IN PATIENTS WITH RHEUMATOID ARTHRITIS USING REAL-WORLD DATA

2019 ◽  
Author(s):  
Evo Alemao ◽  
Sean Connolly ◽  
Yedid Elbez ◽  
Aarti Rao ◽  
Yogesh Saini ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Real World ◽  
Comparative Effectiveness ◽  
Effectiveness Study ◽  
Real World Data ◽  
World Data ◽  
Comparative Effectiveness Study

scholarly journals Utility of Automated Data-adaptive Propensity Score Method for Confounding by Indication in Comparative Effectiveness Study in Real World Medicare and Registry Data

2021 ◽  
Author(s):  
Hiraku Kumamaru ◽  
Jessica J Jalbert ◽  
Louis L Nguyen ◽  
Lauren A Williams ◽  
Hiroaki Miyata ◽  
...  
Keyword(s):  
Propensity Score ◽  
Real World ◽  
Comparative Effectiveness ◽  
Registry Data ◽  
Effectiveness Study ◽  
Confounding By Indication ◽  
Surgical Risk ◽  
High Surgical Risk ◽  
Comparative Effectiveness Study ◽  
Data Adaptive

Background: Confounding by indication is a serious threat to comparative studies using real world data. We assessed the utility of automated data-adaptive analytic approach for confounding adjustment when both claims and clinical registry data are available. Methods: We used a comparative study example of carotid artery stenting (CAS) vs. carotid endarterectomy (CEA) in 2005-2008 when CAS was only indicated for patients with high surgical risk. We included Medicare beneficiaries linked to the Society for Vascular Surgery's Vascular Registry >65 years old undergoing CAS/CEA. We compared hazard ratios (HRs) for death while adjusting for confounding by combining various 1) Propensity score (PS) modeling strategies (investigator-specified [IS-PS] vs. automated data-adaptive [ada-PS]); 2) data sources (claims-only, registry-only and claims-plus-registry); and 3) PS adjustment approaches (matching vs. quintiles-adjustment with/without trimming). An HR of 1.0 was a benchmark effect estimate based on CREST trial. Results: The cohort included 1,999 CAS and 3,255 CEA patients (mean age 76). CAS patients were more likely symptomatic and at high surgical risk, and experienced higher mortality (crude HR=1.82 for CAS vs. CEA). HRs from PS-quintile adjustment without trimming were 1.48 and 1.52 for claims-only IS-PS and ada-PS, 1.51 and 1.42 for registry-only IS-PS and ada-PS, and 1.34 and 1.23 for claims-plus-registry IS-PS and ada-PS, respectively. Estimates from other PS adjustment approaches showed similar patterns. Conclusions: In a comparative effectiveness study of CAS vs. CEA with severe confounding by indication, ada-PS performed better than IS-PS in general, but both claims and registry data were needed to adequately control for bias.

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