scholarly journals Erythema multiforme major with ocular involvement following COVID-19 infection

2021 ◽  
Vol 2021 (11-12) ◽  
Author(s):  
Carla L Maden ◽  
Laura Ah-Kye ◽  
Yasmin Alfallouji ◽  
Elizabeth Kulakov ◽  
Peter Ellery ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Examination ◽  
Erythema Multiforme ◽  
Ocular Involvement ◽  
Topical Steroids ◽  
Eye Drops ◽  
Genital Ulceration ◽  
Normal Visual Acuity ◽  
Erythema Multiforme Major

ABSTRACT We report a case of membranous conjunctivitis and erythema multiforme major (EMM) after a coronavirus disease 2019 (COVID-19) diagnosis. A previously well 18-year-old man presented with increasingly erythematous eyes and oral and genital ulceration 2 weeks after confirmation of COVID-19 infection. Clinical examination showed sloughy membranous conjunctivitis with normal visual acuity. He was reviewed by dermatology and diagnosed with EMM secondary to severe acute respiratory syndrome coronavirus 2 infection. The symptoms resolved with oral and topical steroids, lubricants and chloramphenicol eye drops. Erythema multiforme has been reported in association with COVID-19, although the major form is rare. Ophthalmologists should consider current or previous COVID-19 infection in patients presenting with conjunctivitis or pseudomembrane formation. Prompt initiation of steroids aids resolution.

scholarly journals Сlinical Case of Macular Hole Recurrence after Surgical Treatment with Platelet-Rich Plasma

2020 ◽  
Vol 17 (3) ◽  
pp. 513-518
Author(s):  
D. V. Cherepov ◽  
S. J. Goziev
Keyword(s):  
Visual Acuity ◽  
Surgical Treatment ◽  
Macular Hole ◽  
Clinical Examination ◽  
Platelet Rich Plasma ◽  
Topical Steroid ◽  
Internal Limiting Membrane ◽  
Eye Drops ◽  
Before And After ◽  
Repeated Surgery

Purpose: presentation of a clinical case of an idiopathic macular hole (IMH) recurrence after its successful closure augmented with platelet-rich plasma (PRP) and the results of repeated surgical treatment.Methods. The patient underwent clinical examination and optical coherence tomography (OCT) of the retina before and after surgical treatment. А 2-stage surgical treatment of the left eye with an interval of 7 days: phacoemulsification (PE) followed by microinvasive vitrectomy with Internal limiting membrane peeling (ILM) and closure with the use of PRP. The patient was discharged with improved visual acuity and closure of the macular hole (MH). After 2 weeks vision deterioration was noted by the patient in the operated eye. Clinical examination revealed macular edema (ME) and recurrence of MH. Topical steroid eye drops were used to no avail, with increase of ME and MH via OCT control. Revision of the vitreal cavity augmented with PRP was performed.Results. In follow-up a complete closure of the MH, resolution of ME and improvement in visual acuity after repeated surgery was confirmed.Conclusions. A case of recurrent MH after primary closure with PRP is described. The case suggests a possibility of clinical improvement after repeated MH closure augmented with PRP. The causes and mechanisms of the recurrence of MH are still not clear. Despite the positive results of surgery subsequent OCT retina examination is necessary. 

scholarly journals Topical tacrolimus in ocular Graft Versus Host Disease

2021 ◽  
Author(s):  
Samir Shawki ◽  
Khalid Tabbara
Keyword(s):  
Graft Versus Host Disease ◽  
Term Therapy ◽  
Ocular Involvement ◽  
Topical Steroids ◽  
Eye Drops ◽  
Conjunctival Hyperemia ◽  
Host Disease ◽  
Topical Tacrolimus ◽  
Graft Versus Host ◽  
Punctate Keratitis

Abstract Purpose: To evaluate the safety and efficacy of topical tacrolimus eye drops in the treatment of patients with ocular Graft Versus Host Disease (GVHD).MethodsTen consecutive patients with ocular GVHD were included retrospectively. All patients were treated with topical tacrolimus (0.01% - 0.03%) twice daily. Five patients were given adjunctive topical steroids for 4 to 6 weeks. The outcome measures included improvement of symptoms of photophobia, ocular pain and discharge and signs of superficial punctate keratitis and conjunctival hyperemia. Clinical assessment was carried out before, during and on the last visit after treatment.ResultsThere were 9 males and 1 female patients. The mean age was 30 years (range 5 to 51). All patients had bilateral ocular involvement. Duration of treatment ranged from 2 to 22 months (mean 6.5 months). There was improvement of symptoms in 8/10 (80%), superficial punctate keratitis in 8(40%) out of the 20 eyes and conjunctival hyperemia in 12 (66%) out of 18 eyes. The response to treatment was noted to be late following initiation of therapy (Average 3 weeks; range 1 to 8 weeks). Patients given adjunctive steroids responded faster. The main adverse ocular side effects were burning sensation, redness and swollen lids.ConclusionTopical tacrolimus is a safe and effective long-term therapy in the treatment of patients with ocular GVHD. Adjunctive short-term use of topical steroids may lead to faster response to topical tacrolimus therapy. Patients should be encouraged to continue use of topical tacrolimus as the onset of action may be delayed.

Erythema multiforme major after chemoradiotherapy on tongue cancer patient

2021 ◽  
Author(s):  
Hirokazu Saito ◽  
Yurie Akiyama ◽  
Chiho (Kondo) Hiraga ◽  
Taiki Suzuki ◽  
Satoru Ogane ◽  
...  
Keyword(s):  
Cancer Patient ◽  
Erythema Multiforme ◽  
Tongue Cancer ◽  
Erythema Multiforme Major

On the need for a legislative norm for high degrees of hypermetropia in relation to military-combatant services

1902 ◽  
Vol 2 (10) ◽  
pp. 567-567
Author(s):  
V. F. Velyamovich
Keyword(s):  
Visual Acuity ◽  
Military Service ◽  
Normal Visual Acuity ◽  
The Law

As for the current Russian laws on anomalies in the organs of vision that allow or restrict the ability to perform military service, hyperopia, for which the law does not specify a predetermined degree, is completely ignored, compatible with the requirements of military service. Any hyperopia, no matter how high its degree of abnormal refraction, is recognised as extremely suitable for military service, unless it has a normal visual acuity without glasses.

An Unusual Phenotype in Dutch Patients With Oculocutaneous Albinism Type 4: Evident Hypopigmentation Without Other Ocular Deficits.

2021 ◽  
Author(s):  
Charlotte C Kruijt ◽  
Nicoline E Schalij-Delfos ◽  
Gerard C de Wit ◽  
Ralph F Florijn ◽  
Maria M van Genderen
Keyword(s):  
Visual Acuity ◽  
Visual Pathways ◽  
Oculocutaneous Albinism ◽  
Novel Mutations ◽  
Normal Visual Acuity ◽  
Diagnostic Center ◽  
Foveal Hypoplasia ◽  
Unusual Phenotype ◽  
First Time ◽  
Dutch Cohort

Abstract Purpose: To describe the phenotype of Dutch patients with oculocutaneous albinism type 4 (OCA4).Patients and Methods: We collected data on pigmentation (skin, hair, and eyes), visual acuity (VA), nystagmus, foveal hypoplasia, chiasmal misrouting, and molecular analyses of nine Dutch OCA4 patients from the Bartiméus Diagnostic Center for complex visual disorders.Results: All patients had severely reduced pigmentation of skin, hair, and eyes with iris transillumination over 360 degrees. Three unrelated OCA4 patients had normal VA, no nystagmus, no foveal hypoplasia, and no misrouting of the visual pathways. Six patients had poor visual acuity (0.6 to 1.0 logMAR), nystagmus, severe foveal hypoplasia and misrouting. We found two novel mutations in the SLC45A2 gene, c.310C>T; p.(Pro104Ser), and c.1368+3_1368+9del p.(?).Discussion: OCA4 patients of this Dutch cohort all had hypopigmentation of skin, hair, and iris translucency. However, patients were either severely affected with regard to visual acuity, foveal hypoplasia, and misrouting, or visually not affected at all. We describe for the first time OCA4 patients with an evident lack of pigmentation, but normal visual acuity, normal foveal development and absence of misrouting. This implies that absence of melanin does not invariably lead to foveal hypoplasia and abnormal routing of the visual pathways.

Cerulean Cataract in a Person with Down s Syndrome

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Madbouhi K ◽  
◽  
Cherkaoui O ◽  
Keyword(s):  
Visual Acuity ◽  
Clinical Examination ◽  
Down's Syndrome ◽  
Anterior Segment ◽  
Down’S Syndrome ◽  
Congenital Form ◽  
The Right ◽  
Radial Arrangement ◽  
Loss Of Visual Acuity

We report the case of an 18-year-old patient who consults for a loss of visual acuity in the right eye for 1 year. On clinical examination, visual acuity is 20/100. Eye tone is 12 mmhg. Examination of the anterior segment shows the existence of a cataract made up of whitish opacities corresponding to a congenital cerulean cataract (Figure 1). The treatment consisted of a cataract cure by phacoemulsification with good progress. Cerulean cataract is a rare congenital form of bluish tint, made up of whitish opacities in concentric layers with a radial arrangement at their center. Visual acuity is fairly good in childhood but may deteriorate later. In the literature, the incidence of cataracts in Down’s children ranges from 5% to 50%. In previous studies of congenital or infantile cataract, 3-5 % of cases were associated with Down’s syndrome [1].

Bilateral Optic Nerve Hypoplasia with Normal Visual Acuity

1978 ◽  
Vol 86 (4) ◽  
pp. 524-529 ◽  
Author(s):  
Ake Bjork ◽  
C.-G. Laureix ◽  
Ulla Laurell
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Nerve Hypoplasia ◽  
Normal Visual Acuity

scholarly journals Choroidal Neovascularization Associated with Punctate Inner Choroidopathy: Combination of Intravitreal Anti-VEGF and Systemic Immunosuppressive Therapy

2015 ◽  
Vol 6 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Bettina Hohberger ◽  
Michael Rudolph ◽  
Antonio Bergua
Keyword(s):  
Visual Acuity ◽  
Choroidal Neovascularization ◽  
Combined Therapy ◽  
Retinal Pigment ◽  
Posterior Pole ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Punctate Inner Choroidopathy ◽  
Anti Vegf ◽  
Systemic Medication

Purpose: Choroidal neovascularization (CNV) associated with punctate inner choroidopathy (PIC) is a rare clinical entity, yet still a challenge for medical treatment. A case of a young myopic woman developing CNV secondary to unilateral PIC is presented. Clinical morphology, diagnostic procedure and follow-up are reported. Case Report: A 29-year-old woman presented with multiple yellowish dots at the posterior pole. No other signs of inflammation could be seen. Angiography with fluorescein yielded hyperfluorescent signals in the affected areas with a diffuse leak, and SD-OCT showed a slightly elevated retinal pigment epithelial layer, consistent with the diagnosis of PIC. Additionally a classic CNV was observed. Results: Anti-inflammatory therapy with local prednisolone acetate eye drops in combination with intravitreal injection of anti-vascular endothelial growth factor (VEGF, bevacizumab) yielded an increased best-corrected visual acuity. As CNV reappeared, systemic medication with prednisone and azathioprine in combination with two further intravitreal injections of anti-VEGF stabilized CNV and increased visual acuity again. Conclusion: Combined therapy of immunosuppression with intravitreal anti-VEGF injections can be considered as therapeutic strategy in the management of recurrent CNV associated with PIC.

scholarly journals Amnwiotic Membrane Transplantation as a Treatment for Sterile Infiltration and Corneal Melting after Corneal Crosslinking for Keratoconus

2018 ◽  
Vol 9 (1) ◽  
pp. 185-189 ◽  
Author(s):  
Takanori Sasaki ◽  
Takeshi Ide ◽  
Ikuko Toda ◽  
Naoko Kato
Keyword(s):  
Visual Acuity ◽  
Diclofenac Sodium ◽  
Corneal Stroma ◽  
Amniotic Membrane Transplantation ◽  
Eye Drops ◽  
Epithelial Defect ◽  
Persistent Epithelial Defect ◽  
Corneal Crosslinking ◽  
Corneal Epithelial Defect ◽  
Corneal Melting

We report a case of corneal melting through sterile infiltration presumably due to excessive use of nonsteroidal anti-inflammatory eye drops after corneal crosslinking (CXL). It was treated using steroids combined with amniotic membrane transplantation (AMT). A 33-year-old man with progressing keratoconus underwent left eye CXL. We prescribed betamethasone and levofloxacin eye drops 5 times daily and diclofenac sodium eye drops 3 times daily for 3 days. Three days after CXL, there was a persistent epithelial defect and the left corneal stroma was clouded. His visual acuity remained unchanged. We prescribed betamethasone hourly and 20 mg prednisolone daily. At 1 week after CXL, the corneal epithelial defect and infiltration were unchanged. He had not stopped using diclofenac at the prescribed time. On day 17, we performed AMT and his cornea and visual acuity improved. AMT may be effective against persistent epithelial defects and corneal melting after CXL.

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