scholarly journals Undifferentiated vasculitis or an evolving systemic autoimmune rheumatic disease?

2016 ◽  
Vol 2016 (8) ◽  
pp. omw066
Author(s):  
Nafeesah Fatimah ◽  
Ahmad Ussaid ◽  
Aflak Rasheed
Keyword(s):  
Rheumatic Disease ◽  
Autoimmune Rheumatic Disease ◽  
Systemic Autoimmune Rheumatic Disease

scholarly journals Prevalence and clinical impact of systemic autoimmune rheumatic disease in patients with silicosis

2021 ◽  
Author(s):  
José Jesús Blanco-Pérez ◽  
Victoria Arnalich-Montiel ◽  
Ángel Salgado-Barreira ◽  
María Angel Alvarez-Moure ◽  
Adriana Carolina Caldera-Díaz ◽  
...  
Keyword(s):  
Rheumatic Disease ◽  
Clinical Impact ◽  
Autoimmune Rheumatic Disease ◽  
Systemic Autoimmune Rheumatic Disease

scholarly journals Clinical Phenotypes of Patients with Anti-DFS70/LEDGF Antibodies in a Routine ANA Referral Cohort

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Makoto Miyara ◽  
Roger Albesa ◽  
Jean-Luc Charuel ◽  
Mohamed El Amri ◽  
Marvin J. Fritzler ◽  
...  
Keyword(s):  
Rheumatic Disease ◽  
Indirect Immunofluorescence ◽  
Antinuclear Antibodies ◽  
Clinical Value ◽  
Chemiluminescence Immunoassay ◽  
Clinical Phenotypes ◽  
Autoimmune Rheumatic Disease ◽  
Comparator Group ◽  
Systemic Autoimmune Rheumatic Disease ◽  
Highly Correlated

Objective. To analyze the clinical value of anti-DFS70 antibodies in a cohort of patients undergoing routine antinuclear antibodies (ANAs) testing.Methods. Sera with a dense fine speckled (DFS) indirect immunofluorescence (IIF) pattern from 100 consecutive patients and 100 patients with other IIF patterns were tested for anti-DFS70 antibodies by a novel chemiluminescence immunoassay (CIA) and for ANA by ANA Screen ELISA (both INOVA).Results. Among the 100 patients with a DFS IIF pattern, 91% were anti-DFS70 positive by CIA compared to 3% in the comparator group(P<0.0001). The CIA and IIF titers of anti-DFS antibodies were highly correlated (rho = 0.89). ANA by ELISA was positive in 35% of patients with the DFS IIF pattern as compared to 67% of patients with other patterns(P<0.0001). Only 12.0% of patients with DFS pattern and 13.4% with DFS pattern and anti-DFS70 antibodies detected by CIA had systemic autoimmune rheumatic disease (SARD). Only 5/91 (5.5%) patients with anti-DFS70 antibodies had SARD and their sera were negative on the ANA Screen ELISA.Conclusion. Although anti-DFS70 antibodies cannot exclude the presence of SARD, the likelihood is significantly lower than in patients with other IIF patterns and should be included in test algorithms for ANA testing.

scholarly journals Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1592
Author(s):  
Chiao-Feng Cheng ◽  
Ming-Chieh Shih ◽  
Ting-Yuan Lan ◽  
Ko-Jen Li
Keyword(s):  
Confidence Interval ◽  
Rheumatic Disease ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Test Accuracy ◽  
Summary Receiver Operating Characteristic ◽  
Bivariate Model ◽  
Autoimmune Rheumatic Disease ◽  
Systemic Autoimmune Rheumatic Disease ◽  
Test Result

Anti-DFS70 antibodies have been proposed as a marker to exclude systemic autoimmune rheumatic disease (SARD). We conducted this systematic diagnostic test accuracy review and meta-analysis to determine the performance of anti-DFS70 antibodies in patients with a positive anti-nuclear antibody (ANA) test result to exclude SARD. We searched PubMed, Embase, Web of Science, Scopus and the Cochrane Library up to 22 February 2021, and included studies examining the diagnostic accuracy of anti-DFS70 antibodies in patients with a positive ANA test result. The results were pooled using a hierarchical bivariate model and plotted in summary receiver operating characteristic curves. R software and Stata Statistical Software were used for the statistical analysis. Eight studies with 4168 patients were included. The summary sensitivity was 0.19 (95% confidence interval: 0.12–0.28) and the specificity was 0.93 (95% confidence interval: 0.88–0.96). The area under the curve was 0.69 (95% confidence interval: 0.64–0.72). The meta-regression analysis showed that targeting only ANA-associated rheumatic disease was associated with higher specificity. In addition, the studies with a non-SARD prevalence of <80% and using a chemiluminescence assay were associated with higher specificity. Anti-DFS70 antibodies have high specificity for the exclusion of SARD among patients presenting with a positive ANA test, but the sensitivity is low.

scholarly journals P90 Genetic risk, smoking and the development of systemic autoimmune rheumatic disease

2020 ◽  
Author(s):  
Henrik Christian Bidstrup Leffers ◽  
David Westergaard ◽  
Karina Banasik ◽  
Søren Jacobsen
Keyword(s):  
Rheumatic Disease ◽  
Genetic Risk ◽  
Autoimmune Rheumatic Disease ◽  
Systemic Autoimmune Rheumatic Disease

Systemic Autoimmune Rheumatic Disease Prevalence in Canada: Updated Analyses Across 7 Provinces

2014 ◽  
Vol 41 (4) ◽  
pp. 673-679 ◽  
Author(s):  
Laurel Broten ◽  
J. Antonio Aviña-Zubieta ◽  
Diane Lacaille ◽  
Lawrence Joseph ◽  
John G. Hanly ◽  
...  
Keyword(s):  
Rheumatic Disease ◽  
Lupus Erythematosus ◽  
Latent Class ◽  
Population Based ◽  
Case Definition ◽  
Case Definitions ◽  
Autoimmune Rheumatic Disease ◽  
Primary Sjögren Syndrome ◽  
Physician Billing ◽  
Systemic Autoimmune Rheumatic Disease

Objective.To estimate systemic autoimmune rheumatic disease (SARD) prevalence across 7 Canadian provinces using population-based administrative data evaluating both regional variations and the effects of age and sex.Methods.Using provincial physician billing and hospitalization data, cases of SARD (systemic lupus erythematosus, scleroderma, primary Sjögren syndrome, polymyositis/dermatomyositis) were ascertained. Three case definitions (rheumatology billing, 2-code physician billing, and hospital diagnosis) were combined to derive a SARD prevalence estimate for each province, categorized by age, sex, and rural/urban status. A hierarchical Bayesian latent class regression model was fit to account for the imperfect sensitivity and specificity of each case definition. The model also provided sensitivity estimates of different case definition approaches.Results.Prevalence estimates for overall SARD ranged between 2 and 5 cases per 1000 residents across provinces. Similar demographic trends were evident across provinces, with greater prevalence in women and in persons over 45 years old. SARD prevalence in women over 45 was close to 1%. Overall sensitivity was poor, but estimates for each of the 3 case definitions improved within older populations and were slightly higher for men compared to women.Conclusion.Our results are consistent with previous estimates and other North American findings, and provide results from coast to coast, as well as useful information about the degree of regional and demographic variations that can be seen within a single country. Our work demonstrates the usefulness of using multiple data sources, adjusting for the error in each, and providing estimates of the sensitivity of different case definition approaches.

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