Natural Selection in Large Populations
2020 ◽
pp. 109-146
Keyword(s):
This chapter includes selection in haploid and diploid organisms, hard and soft selective sweeps, background selection, and the probability of ultimate survival of a new favorable mutation in a large population. It considers overdominance and heterozygote inferiority in detail as well as different types of equilibria and the fundamental theorem of natural selection. Various types of balancing selection are examined including mutation–selection balance, migration–selection balance, meiotic drive and gametic selection, and the theory of CRISPR-mediated gene drive to control natural populations. It closes with a discussion of other modes of selection and their implications.
2007 ◽
Vol 274
(1611)
◽
pp. 861-869
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2011 ◽
Vol 279
(1732)
◽
pp. 1412-1420
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