Cardiovascular System

2019 ◽  
pp. 461-485
Author(s):  
Kevin S. Shah ◽  
Kalyanam Shivkumar ◽  
Mehdi Nojoumi ◽  
Barbara Natterson-Horowitz
Keyword(s):  
Phylogenetic Information ◽  
Healthy Human ◽  
Selective Pressures ◽  
Evolutionary Origins ◽  
Trade Offs ◽  
Species Vulnerability ◽  
System P ◽  
History Of ◽  
Cv Disease ◽  
Comparative Information

Cardiovascular (CV) disease is the leading killer of our species. Various evolutionary lenses can be applied to better understand human vulnerability to CV disorders. The evolutionary origins of a healthy human heart—its myocardial, electrophysiologic, valvular and vascular systems—offers a history of the selective pressures, trade-offs and adaptations leading to the normal mammalian CV systems. Beyond these evolutionary-developmental perspectives, the application of a framework based on Tinbergen’s four questions offers a novel evolutionary lens for understanding our species’ vulnerability to CV pathology. This is done by a consideration of comparative information about non-human animals who spontaneously develop the same CV diseases. This phylogenetic information can then be used to develop trade-off-based adaptive hypotheses to explain the nature and origins of vulnerability to a range of CV pathologies including atherosclerosis, heart failure, valvular heart disease and arrhythmias.

Conclusion: What is Speculative Empiricism?

2018 ◽  
Author(s):  
Didier Debaise
Keyword(s):  
Social Groups ◽  
Speculative Philosophy ◽  
System P ◽  
History Of ◽  
Selection Of

Process and Reality ends with a warning: ‘[t]he chief danger to philosophy is narrowness in the selection of evidence’ (PR, 337). Although this danger of narrowness might emerge from the ‘idiosyncrasies and timidities of particular authors, of particular social groups, of particular schools of thought, of particular epochs in the history of civilization’ (PR, 337), we should not be mistaken: it occurs within philosophy, in its activity, its method. And the fact that this issue arises at the end of Process and Reality reveals the ambition that has accompanied its composition: Whitehead has resisted this danger through the form and ambition of his speculative construction. The temptation of a narrowness in selection attempts to expel speculative philosophy at the same time as it haunts each part of its system.

Drifting Through a Planetary System

2018 ◽  
Author(s):  
Karel Schrijver
Keyword(s):  
Seventeenth Century ◽  
Solar System ◽  
Virtual Worlds ◽  
Planetary System ◽  
System P ◽  
History Of ◽  
Or Team ◽  
Water Contents

This chapter describes how the first found exoplanets presented puzzles: they orbited where they should not have formed or where they could not have survived the death of their stars. The Solar System had its own puzzles to add: Mars is smaller than expected, while Venus, Earth, and Mars had more water—at least at one time—than could be understood. This chapter shows how astronomers worked through the combination of these puzzles: now we appreciate that planets can change their orbits, scatter water-bearing asteroids about, steal material from growing planets, or team up with other planets to stabilize their future. The special history of Jupiter and Saturn as a pair bringing both destruction and water to Earth emerged from the study of seventeenth-century resonant clocks, from the water contents of asteroids, and from experiments with supercomputers imposing the laws of physics on virtual worlds.

Beyond Bias

2020 ◽  
pp. 736-753
Author(s):  
Chelsea Barabas
Keyword(s):  
Best Practices ◽  
Criminal Law ◽  
Criminal Justice Reform ◽  
Trade Offs ◽  
System P ◽  
Accuracy Measures ◽  
Criminal Legal System ◽  
And Function ◽  
Role And Function

This chapter discusses contemporary debates regarding the use of artificial intelligence as a vehicle for criminal justice reform. It closely examines two general approaches to what has been widely branded as “algorithmic fairness” in criminal law: the development of formal fairness criteria and accuracy measures that illustrate the trade-offs of different algorithmic interventions; and the development of “best practices” and managerialist standards for maintaining a baseline of accuracy, transparency, and validity in these systems. Attempts to render AI-branded tools more accurate by addressing narrow notions of bias miss the deeper methodological and epistemological issues regarding the fairness of these tools. The key question is whether predictive tools reflect and reinforce punitive practices that drive disparate outcomes, and how data regimes interact with the penal ideology to naturalize these practices. The chapter then calls for a radically different understanding of the role and function of the carceral state, as a starting place for re-imagining the role of “AI” as a transformative force in the criminal legal system.

Digitally Mediated Identity in the Cases of Two Sámi Artists

2017 ◽  
Author(s):  
Ann Werner
Keyword(s):  
Cultural Issues ◽  
Global Media ◽  
Dominant Form ◽  
Industry Studies ◽  
Media System ◽  
Internet Users ◽  
System P ◽  
Music Consumption ◽  
History Of ◽  
Streaming Services

This chapter explores identity issues in commercial streaming services, which have grown steadily in the 2010s to become the dominant form of music consumption in the Nordic countries, with about 60% of all Internet users in 2015. The chapter offers an alternative to the dominant trend in music industry studies by focusing not on the industry’s interests but instead on broader cultural issues. The chapter presents case studies of two female Sámi artists and their representations on Spotify, YouTube, MySpace, and artists’ websites, taking various aspects of the services into account, including the interface and the algorithm-based recommendations. Informed by feminist cultural studies, the argument is that the industry continues a history of reinforcing stereotypes of ethnicity, indigeneity, and femininity. Thus, commercial streaming is not only making music available to global audiences, it is also selling images of Otherness within an unequal capitalist global media system.

2005 Verriest Medal awarded to Professor John D. Mollon

2006 ◽  
Vol 23 (3-4) ◽  
pp. ii-ii
Keyword(s):  
Color Vision ◽  
Full Spectrum ◽  
Visual Neuroscience ◽  
Evolutionary Origins ◽  
University Of Cambridge ◽  
Color Vision Tests ◽  
Spectral Coding ◽  
History Of ◽  
The University

The International Colour Vision Society awarded the 2005 Verriest Medal to John D. Mollon, Professor of Visual Neuroscience at the University of Cambridge, UK. This award is bestowed by the Society to honor long-term contributions to the field of color vision. If the field of color vision were itself a rainbow, then Professor Mollon's contributions cover nearly its full spectrum, including the isolation and elucidation of basic chromatic coding mechanisms and the constraints that they impose on human (and more generally primate) visual performance, the genetic basis of spectral coding mechanisms, the ecological influences on and evolutionary origins of chromatic discrimination. He has been instrumental in the design of several new color vision tests and has extensively exploited abnormal models, both congenital and acquired, to further our understanding of normal mechanisms. He is especially appreciated for his keen and profound sense of the history of science, in particular with respect to the field of color vision. He has been a member of the society for over 25 years and is currently serving on its board of directors. He organized the 2001 ICVS meeting in Cambridge, celebrating the bicentennial of Thomas Young's lecture on color vision.

Life history of tundra-dwelling wolf spiders (Araneae: Lycosidae) from the Yukon Territory, Canada

2012 ◽  
Vol 90 (6) ◽  
pp. 714-721 ◽  
Author(s):  
J.J. Bowden ◽  
C.M. Buddle
Keyword(s):  
Reproductive Effort ◽  
Abiotic Factors ◽  
Wolf Spider ◽  
Local Variation ◽  
Yukon Territory ◽  
The Arctic ◽  
Wolf Spiders ◽  
Female Body Size ◽  
Trade Offs ◽  
History Of

We studied populations of three tundra-dwelling wolf spider (Lycosidae) species to determine reproductive trait relationships and developmental timing in the Arctic. We collected 451 Pardosa lapponica (Thorell, 1872), 176 Pardosa sodalis Holm, 1970, and 117 Pardosa moesta Banks, 1892 during summer 2008. We used log-likelihood ratio tests and multiple linear regressions to determine the best predictors of fecundity and relative reproductive effort. Female body size best explained the variation in fecundity and body condition was the best predictor for relative reproductive effort. We tested for a trade-off between the allocation of resources to individual eggs and the number of eggs produced (fecundity) within each species using linear regression. There was variation in detectable egg size and number trade-offs among sites and these may be related to local variation in resource allocation linked to density-related biotic or abiotic factors. These findings contribute to knowledge about the fitness of arctic wolf spiders in the region of study and are particularly relevant in light of the effects that climate changes are predicted to have on the arctic fauna.

scholarly journals Is there a link between glucose levels and heart failure? An update

2010 ◽  
Vol 54 (5) ◽  
pp. 488-497 ◽  
Author(s):  
Arnaldo Schainberg ◽  
Antônio Ribeiro-Oliveira Jr. ◽  
José Marcio Ribeiro
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Epidemiological Studies ◽  
Left Ventricular ◽  
Glucose Levels ◽  
Factors Analysis ◽  
History Of ◽  
Cv Disease ◽  
The Relationship

It has been well documented that there is an increased prevalence of standard cardiovascular (CV) risk factors in association with diabetes and with diabetes-related abnormalities. Hyperglycemia, in particular, also plays an important role. Heart failure (HF) has become a frequent manifestation of cardiovascular disease (CVD) among individuals with diabetes mellitus. Epidemiological studies suggest that the effect of hyperglycemia on HF risk is independent of other known risk factors. Analysis of datasets from populations including individuals with dysglycemia suggests the pathogenic role of hyperglycemia on left ventricular function and on the natural history of HF. Despite substantial epidemiological evidence of the relationship between diabetes and HF, data from available interventional trials assessing the effect of a glucose-lowering strategy on CV outcomes are limited. To provide some insight into these issues, we describe in this review the recent important data to understand the natural course of CV disease in diabetic individuals and the role of hyperglycemia at different times in the progression of HF.

scholarly journals A short history of ocean acidification science in the 20th century: a chemist's view

2013 ◽  
Vol 10 (11) ◽  
pp. 7411-7422 ◽  
Author(s):  
P. G. Brewer
Keyword(s):  
Ocean Acidification ◽  
20Th Century ◽  
Fossil Fuel ◽  
Trade Offs ◽  
History Of ◽  
Chemical Knowledge ◽  
The Creation ◽  
Ph Scale ◽  
The Impact

Abstract. This review covers the development of ocean acidification science, with an emphasis on the creation of ocean chemical knowledge, through the course of the 20th century. This begins with the creation of the pH scale by Sørensen in 1909 and ends with the widespread knowledge of the impact of the "High CO2 Ocean" by then well underway as the trajectory along the IPCC scenario pathways continues. By mid-century the massive role of the ocean in absorbing fossil fuel CO2 was known to specialists, but not appreciated by the greater scientific community. By the end of the century the trade-offs between the beneficial role of the ocean in absorbing some 90% of all heat created, and the accumulation of some 50% of all fossil fuel CO2 emitted, and the impacts on marine life were becoming more clear. This paper documents the evolution of knowledge throughout this period.

The Next Space Patrons

2017 ◽  
Author(s):  
Alexander MacDonald
Keyword(s):  
Solar System ◽  
Political History ◽  
Space Exploration ◽  
Development Program ◽  
The Political ◽  
Early American ◽  
Long Run ◽  
Space Race ◽  
System P ◽  
History Of

Mankind will not remain forever confined to the Earth. In pursuit of light and space it will, timidly at first, probe the limits of the atmosphere and later extend its control to the entire solar system. —Konstantin Tsiolkovsky, Letter to B. N. Vorobyev, 1911 What do we learn from this long-run perspective on American space exploration? How does it change our understanding of the history of spaceflight? How does it change our understanding of the present? This book has provided an economic perspective on two centuries of history, with examinations of early American observatories, the rocket development program of Robert Goddard, and the political history of the space race. Although the subjects covered have been wide-ranging, together they present a new view of American space history, one that challenges the dominant narrative of space exploration as an inherently governmental activity. From them a new narrative emerges, that of the Long Space Age, a narrative that in the ...

scholarly journals Vertebrate cardiac regeneration: evolutionary and developmental perspectives

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Stephen Cutie ◽  
Guo N. Huang
Keyword(s):  
Cardiac Injury ◽  
Adaptive Immune System ◽  
Cardiac Regeneration ◽  
Heart Regeneration ◽  
Adaptive Immune ◽  
Selective Pressures ◽  
Trade Offs ◽  
Lower Vertebrates ◽  
Complex Adaptive ◽  
And Function

AbstractCardiac regeneration is an ancestral trait in vertebrates that is lost both as more recent vertebrate lineages evolved to adapt to new environments and selective pressures, and as members of certain species developmentally progress towards their adult forms. While higher vertebrates like humans and rodents resolve cardiac injury with permanent fibrosis and loss of cardiac output as adults, neonates of these same species can fully regenerate heart structure and function after injury – as can adult lower vertebrates like many teleost fish and urodele amphibians. Recent research has elucidated several broad factors hypothesized to contribute to this loss of cardiac regenerative potential both evolutionarily and developmentally: an oxygen-rich environment, vertebrate thermogenesis, a complex adaptive immune system, and cancer risk trade-offs. In this review, we discuss the evidence for these hypotheses as well as the cellular participators and molecular regulators by which they act to govern heart regeneration in vertebrates.

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