Carbon-nanotube field emission electron and X-ray technology for medical research and clinical applications

Mapping Intimacies ◽

10.1093/oxfordhb/9780199533060.013.19 ◽

2017 ◽

Author(s):

Sigen Wang ◽

Otto Zhou ◽

Sha Chang

Keyword(s):

Carbon Nanotube ◽

Medical Research ◽

Single Cell ◽

Field Emission ◽

Small Animal ◽

Clinical Applications ◽

X Ray ◽

Clinical Cancer ◽

Cell Irradiation ◽

Cancer Studies

This article describes carbon-nanotube based X-ray technologies for medical research and clinical applications, including an X-ray source, microfocus X-ray tube, microcomputed tomography scanner, stationary digital breast tomosynthesis, microradiotherapy system, and single-cell irradiation system. It first examines electron field emission from carbon nanotubes before discussing carbon-nanotube field emission electron and X-ray technologies in greater detail. It highlights the enormous promise of these systems in commercial and research application for the future in diagnostic medical imaging; in-vivo imaging of small-animal modelsfor pre-clinical cancer studies; security screening; industrial inspection; cancer radiotherapy of small-animal models for pre-clinical cancer studies; and basic cancer research using single-cell irradiation.

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SU-GG-J-130: Recent Development of a Carbon Nanotube Field Emission Based X-Ray Micro-Radiotherapy System for Small Animal Radiotherapy

Medical Physics ◽

10.1118/1.3468354 ◽

2010 ◽

Vol 37 (6Part11) ◽

pp. 3175-3175

Author(s):

S Wang ◽

R Peng ◽

J Zhang ◽

E Schreiber ◽

O Zhou ◽

...

Keyword(s):

Carbon Nanotube ◽

Field Emission ◽

Small Animal ◽

X Ray ◽

Small Animal Radiotherapy

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A dynamic micro-CT scanner with a stationary mouse bed using a compact carbon nanotube field emission x-ray tube

10.1117/12.813817 ◽

2009 ◽

Cited By ~ 4

Author(s):

Guohua Cao ◽

Xiomara Calderon-Colon ◽

Peng Wang ◽

Laurel Burk ◽

Yueh Z. Lee ◽

...

Keyword(s):

Carbon Nanotube ◽

Field Emission ◽

Micro Ct ◽

Ct Scanner ◽

X Ray

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Single-cell resolution in high-resolution synchrotron X-ray CT imaging with gold nanoparticles

Journal of Synchrotron Radiation ◽

10.1107/s1600577513029007 ◽

2013 ◽

Vol 21 (1) ◽

pp. 242-250 ◽

Cited By ~ 17

Author(s):

Elisabeth Schültke ◽

Ralf Menk ◽

Bernd Pinzer ◽

Alberto Astolfo ◽

Marco Stampanoni ◽

...

Keyword(s):

Gold Nanoparticles ◽

Single Cell ◽

Brain Tumour ◽

Ex Vivo ◽

Small Animal ◽

C6 Glioma Cells ◽

X Ray ◽

Local Tomography ◽

The Brain

Gold nanoparticles are excellent intracellular markers in X-ray imaging. Having shown previously the suitability of gold nanoparticles to detect small groups of cells with the synchrotron-based computed tomography (CT) technique bothex vivoandin vivo, it is now demonstrated that even single-cell resolution can be obtained in the brain at leastex vivo. Working in a small animal model of malignant brain tumour, the image quality obtained with different imaging modalities was compared. To generate the brain tumour, 1 × 105C6 glioma cells were loaded with gold nanoparticles and implanted in the right cerebral hemisphere of an adult rat. Raw data were acquired with absorption X-ray CT followed by a local tomography technique based on synchrotron X-ray absorption yielding single-cell resolution. The reconstructed synchrotron X-ray images were compared with images obtained by small animal magnetic resonance imaging. The presence of gold nanoparticles in the tumour tissue was verified in histological sections.

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