The Ribosome Modulation Factor (RMF) Binding Site on the 100S Ribosome of Escherichia coli

2002 ◽  
Vol 132 (6) ◽  
pp. 983-989 ◽  
Author(s):  
H. Yoshida ◽  
Y. Maki ◽  
H. Kato ◽  
H. Fujisawa ◽  
K. Izutsu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Binding Site ◽  
Modulation Factor ◽  
Ribosome Modulation Factor

scholarly journals Ribosomal Hibernation-Associated Factors in Escherichia coli

2021 ◽  
Vol 10 (1) ◽  
pp. 33
Author(s):  
Yasushi Maki ◽  
Hideji Yoshida
Keyword(s):  
Escherichia Coli ◽  
Biofilm Formation ◽  
Amino Acid Starvation ◽  
Stress Conditions ◽  
Metabolic Energy ◽  
Bacterial Survival ◽  
Modulation Factor ◽  
Translational Activity ◽  
Related Proteins ◽  
Ribosome Modulation Factor

Bacteria convert active 70S ribosomes to inactive 100S ribosomes to survive under various stress conditions. This state, in which the ribosome loses its translational activity, is known as ribosomal hibernation. In gammaproteobacteria such as Escherichia coli, ribosome modulation factor and hibernation-promoting factor are involved in forming 100S ribosomes. The expression of ribosome modulation factor is regulated by (p)ppGpp (which is induced by amino acid starvation), cAMP-CRP (which is stimulated by reduced metabolic energy), and transcription factors involved in biofilm formation. This indicates that the formation of 100S ribosomes is an important strategy for bacterial survival under various stress conditions. In recent years, the structures of 100S ribosomes from various bacteria have been reported, enhancing our understanding of the 100S ribosome. Here, we present previous findings on the 100S ribosome and related proteins and describe the stress-response pathways involved in ribosomal hibernation.

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