scholarly journals How is diarrhoea managed in UK care homes? A survey with implications for recognition and control of Clostridium difficile infection

2010 ◽  
Vol 32 (4) ◽  
pp. 472-478 ◽  
Author(s):  
H. J. Henderson ◽  
L. Maddock ◽  
S. Andrews ◽  
P. Trail ◽  
N. Loades ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Homes ◽  
And Control

New advances in Clostridium difficile infection: changing epidemiology, diagnosis, treatment and control

2008 ◽  
Vol 7 (6) ◽  
pp. 591-598 ◽  
Author(s):  
Herbert L DuPont ◽  
Kevin Garey ◽  
Juan-Pablo Caeiro ◽  
Zhi-Dong Jiang
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
And Control

scholarly journals Colonic lavage in treatment of refractory Clostridium difficile infection: an adaptation of the Pittsburgh protocol

2020 ◽  
Vol 2020 (7) ◽  
Author(s):  
Maura Morgan ◽  
Timothy Farrell ◽  
Gordian U Ndubizu ◽  
Timothy J Farrell
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Surgical Intervention ◽  
Total Colectomy ◽  
Loop Ileostomy ◽  
Ileocecal Valve ◽  
Retrograde Flow ◽  
Fecal Stream ◽  
Colonic Lavage ◽  
And Control

Abstract Clostridium difficile infection (CDI) is a common nosocomial sequela in patients treated with antibiotics. Surgical intervention is indicated in fulminant cases. However, the mortality associated with total colectomy and end ileostomy is high. Previous reports have indicated that surgical intervention for severe complicated CDI with formation of a loop ileostomy leading to the diversion of fecal stream followed by colonic lavage can be beneficial in treating severe CDI. This procedure is known as the Pittsburgh protocol and has been reported to decrease the mortality and the need for a total colectomy in patients with severe complicated CDI. In this case, we present a 75-year-old female with refractory CDI. In her treatment, we adapted the Pittsburgh protocol and utilized a 20-French MIC gastrostomy tube to recreate the ileocecal valve and control the colonic lavage without retrograde flow.

New advances in Clostridium difficile infection: changing epidemiology, diagnosis, treatment and control

2008 ◽  
Vol 21 (5) ◽  
pp. 500-507 ◽  
Author(s):  
Herbert L DuPont ◽  
Kevin Garey ◽  
Juan-Pablo Caeiro ◽  
Zhi-Dong Jiang
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
And Control

Self-Administered Home Series Fecal “Minitransplants” for Recurrent Clostridium difficile Infection on a Rectal Remnant

2015 ◽  
Vol 24 (4) ◽  
pp. 531-533 ◽  
Author(s):  
Daniel Popa ◽  
Mihaela Laszlo ◽  
Lidia Ciobanu ◽  
Elena Ucenic ◽  
Manuela Mihalache ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Toxic Megacolon ◽  
Fecal Microbiota ◽  
Recurrent Infections ◽  
Resonance Imaging ◽  
Vaginal Infection ◽  
Fecal Microbiota Transplant ◽  
Recurrent Clostridium Difficile Infection

A fecal microbiota transplant has proved to be an extremely effective method for patients with recurrent infections with Clostridium difficile. We present the case of a 65-year-old female patient with multiple Clostridium difficile infection (CDI) relapses on the rectal remnant, post-colectomy for a CDI-related toxic megacolon. The patient also evidenced associated symptomatic Clostridium difficile vaginal infection. She was successfully treated with serial fecal “minitransplants” (self-administered at home) and metronidazole ovules.Abbreviations: GI: gastrointestinal; MRI: magnetic resonance imaging; CDI: Clostridium difficile infection; FMT: fecal microbiota transplant.

Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer

2016 ◽  
Vol 25 (3) ◽  
pp. 385-388 ◽  
Author(s):  
Yvette H. Van Beurden ◽  
Tom Van Gils ◽  
Nienke A. Van Gils ◽  
Zain Kassam ◽  
Chris J.J. Mulder ◽  
...  
Keyword(s):  
Celiac Disease ◽  
T Cell ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Cell Lymphoma ◽  
Fecal Microbiota ◽  
Disease Type ◽  
T Cell Lymphoma ◽  
Type Ii ◽  
Refractory Celiac Disease

Treatment of refractory celiac disease type II (RCD II) and preventing the development of an enteropathy associated T-cell lymphoma in these patients is still difficult. In this case report, we describe a patient with RCD II who received fecal microbiota transfer as treatment for a recurrent Clostridium difficile infection, and remarkably showed a full recovery of duodenal villi and disappearance of celiac symptoms. This case suggests that altering the gut microbiota may hold promise in improving the clinical and histological consequences of celiac disease and/or RCD II. Abbreviations: CDI: Clostridium difficile infection; EATL : enteropathy associated T-cell lymphoma; FMT: fecal microbiota transfer; IEL: intraepithelial lymphocytes; RCD II: refractory celiac disease type II; TPN: total parenteral nutrition.

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