scholarly journals Elevated IL 23 in Hypertensive Patients with Acutely Increased Blood Pressure

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
F Abo-Ali ◽  
E E Ahmed ◽  
M A El-deeb ◽  
A E A Basry
Keyword(s):  
Blood Pressure ◽  
Pressure Increase ◽  
Chronic Medical Condition ◽  
Sudden Increase ◽  
Adult Individual ◽  
Hypertensive Patients ◽  
Blood Pressure Increase ◽  
Function Tests ◽  
Acute Increase ◽  
Group B

Abstract Background As a chronic medical condition characterized by elevated blood pressure, hypertension is recognized as a major risk factor for a variety of life threatening diseases including stroke, myocardial infarction, heart failure and aortic aneurysm. And most of these severe complications occur in the hypertensive patients with a sudden increase of blood pressure. Aim of the Work The aim of this study is To evaluate the role of IL23 in the immune pathogenesis of hypertension. Subjects and Methods This was a prospective Case-Control study was carried out in the Internal Medicine Department, faculty of medicine, Ain Shams university hospital during the period from November 2016 to December 2017.In this study we performed full history taking and examination, we also performed complete blood count, liver function tests, kidney function tests, estimation of IL23 level in plasma by ELISA in peripheral blood by Flowcytometry. Forty five adult individual were recruited in the study and were further divided into three groups according to the symptoms of blood pressure as follow:group A patients with acute increase of blood pressure, group B patients without acute increase of blood pressure.and group C healthy volunteers with normal blood pressure as control Results we found that mean of IL23/CD4% was higher in group A, followed by group B then group C, all these differences was high significant Conclusion We demonstrated that IL-23 may be involved in the pathogenesis of acute blood pressure increase in the patients with hypertension. Understanding its inflammatory characterization might be of fundamental importance for the prevention and treatment of acute blood pressure increase in hypertensive patients.

Bioinformatics Study on Serum Triglyceride Levels for Analysis of a Potential Risk Factor Affecting Blood Pressure Variability

2019 ◽  
Vol 14 (5) ◽  
pp. 376-385 ◽  
Author(s):  
Lin Xu ◽  
Jiangming Huang ◽  
Zhe Zhang ◽  
Jian Qiu ◽  
Yan Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Partial Correlation ◽  
Pearson Correlation ◽  
Target Organ Damage ◽  
Serum Triglyceride ◽  
Hypertensive Patients ◽  
Group A ◽  
Group B

Objective: The purpose of this study was to establish whether Triglycerides (TGs) are related to Blood Pressure (BP) variability and whether controlling TG levels leads to better BP variability management and prevents Cardiovascular Disease (CVD). Methods: In this study, we enrolled 106 hypertensive patients and 80 non-hypertensive patients. Pearson correlation and partial correlation analyses were used to define the relationships between TG levels and BP variability in all subjects. Patients with hypertension were divided into two subgroups according to TG level: Group A (TG<1.7 mmol/L) and Group B (TG>=1.7 mmol/L). The heterogeneity between the two subgroups was compared using t tests and covariance analysis. Results: TG levels and BP variability were significantly different between the hypertensive and non-hypertensive patients. Two-tailed Pearson correlation tests showed that TG levels are positively associated with many BP variability measures in all subjects. After reducing other confounding factors, the partial correlation analysis revealed that TG levels are still related to the Standard Deviation (SD), Coefficient of Variation (CV) of nighttime systolic blood pressure and CV of nighttime diastolic blood pressure, respectively (each p<0.05). In the subgroups, group A had a lower SD of nighttime Systolic Blood Pressure (SBP_night_SD; 11.39±3.80 and 13.39±4.16, p=0.011), CV of nighttime systolic blood pressure (SBP_night_CV; 0.09±0.03 and 0.11±0.03, p=0.014) and average real variability of nighttime systolic blood pressure (SBP_night_ARV; 10.99±3.98 and 12.6±3.95, p=0.024) compared with group B, even after adjusting for age and other lipid indicators. Conclusion: TG levels are significantly associated with BP variability and hypertriglyceridemia, which affects blood pressure variability before causing target organ damage.

The Effect of Prophylactic Ephedrine on Systemic Hypotension Caused by Induction of Anaesthesia with Propofol and Sufentanil in Elderly Hypertensive Patients: A Prospective Randomized, Double-blind Placebo-controlled Clinical Trial

2020 ◽  
Keyword(s):  
Blood Pressure ◽  
General Anesthesia ◽  
Normal Saline ◽  
Saline Group ◽  
Normal Saline Group ◽  
Hypertensive Patients ◽  
Group A ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients ◽  
Group B

Objective: To study the effectiveness of prophylactic ephedrine to prevent hypotension caused by induction of anesthesia with propofol and sufentanil in elderly hypertensive patients. Methodology: 70 elderly ASA grade II-III hypertensive patients undergoing elective general anesthesia were randomized into two groups to receive either intravenous ephedrine,100 ug/kg in 5ml normal saline (Group B), or an equal volume of normal saline (Group A) before induction. Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Heart Rate (HR) were recorded at T0 (after entry to the operating room), T1 (1 min after induction), T2 (2 min after induction), T3 ( 3 min after induction), T4 (4 min after induction), T5 (when intubated), T6 (2 min after intubation), and T7 (at the start of the procedure), as well as the incidence of hypotension and bradycardia. Results: SBP, DBP and HR were not significantly different at T0 and were significantly different at T1 to T7 after anesthesia induction. There were statistically significant effect on hypotension and bradycardia between the two groups and group B have a lower risk of hypotension and bradycardia relative to group A. SBP and DBP decreased significantly after induction in both groups. HR decreased significantly in group A while increased in group B. Conclusion: Ephedrine pretreatment can minimize hypotension and bradycardia caused by propofol and sufentanil during the induction of general anesthesia in elderly patients with hypertension.

Menopause-related blood pressure increase and its relationship to age and body mass index: the SIMONA epidemiological study

2005 ◽  
Vol 23 (12) ◽  
pp. 2269-2276 ◽  
Author(s):  
Alberto Zanchetti ◽  
Rita Facchetti ◽  
Gian Carlo Cesana ◽  
Maria Grazia Modena ◽  
Anna Pirrelli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Epidemiological Study ◽  
Body Mass ◽  
Pressure Increase ◽  
Blood Pressure Increase

Blood Pressure and Intraventricular Hemorrhage in Premature Infants

PEDIATRICS ◽  
1990 ◽  
Vol 86 (6) ◽  
pp. 1006-1007
Author(s):  
EDWARD H. PERRY ◽  
HENRIETTA S. BADA ◽  
JOHN D. DAY ◽  
SHELDON B. KORONES ◽  
KRISTOPHER L. ARHEART ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Premature Infants ◽  
Intraventricular Hemorrhage ◽  
Stability Boundary ◽  
Mean Blood Pressure ◽  
Pressure Increase ◽  
Blood Pressure Increase ◽  
The Mean

In Reply.— We appreciate the interest and comments of Drs Puccio and Soliani regarding our article "Blood Pressure Increase, Birth Weight Dependent Stability Boundary and Intraventricular Hemorrhage."1 In response, we address the following points: 1. Although mean blood pressure (BP) values greater than 100 mm Hg were observed in some of our patients, these were quite rare. The mean BP was found to be less than 60 mm Hg 99% of the time. Thus, unless one is recording BPs through long periods and sampling quite often, the brief spikes likely would not be observed.

scholarly journals The Influence of Noise Intensity and Age to the Employees’ Blood Pressure at Heavy-Duty Shop and EHS Department

2019 ◽  
Vol 8 (2) ◽  
pp. 168
Author(s):  
Achmad Fachrul Megananda ◽  
Tjipto Suwandi
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Noise Intensity ◽  
Health Problems ◽  
Pressure Increase ◽  
P Value ◽  
Heavy Duty ◽  
Blood Pressure Increase ◽  
Influence Of Noise

Introduction: Noise is an unwanted sound heard by the hearers, which can trigger health problems if it continues to be exposed to a certain intensity. One of the health problems that can arise due to noise is the blood pressure increase. This study aims to analyze the influence of noise intensity and age to the blood pressure increase. Methods: This study was an observational study completed with cross-sectional design and analytics. The independent variables in this study were the noise intensity and age, while the dependent variable was the blood pressure. The sample collection of this study applied the total sampling method with 46 employees as respondents, i.e., 29 employees of the heavy-duty shop and 17 employees of the EHS Department in PT. Vale Indonesia. The data analysis was conducted by using the logistic regression statistical test with α-value of 0.05. Results: the noise intensity affected the increase of both systolic blood pressure (significance/p-value=0.00) and diastolic blood pressure (significance/p-value=0.01) with an odds ratio of the increase of systolic blood pressure (Exp (B) =9.75) and the increase of diastolic blood pressure (Exp (B)=5.76). Furthermore, the variable of age does not influence the increase of both systolic (significance/p-value=0.57) and diastolic (significance/p-value=0.41) blood pressures. Conclusion:  the rise of the blood pressure of the employees is affected by the noise intensity factor in the workplace. Keywords: noise intensity, age, blood pressure

scholarly journals SAFETY OF USE OF HIGH ALTITUDE PROTECTION SUITS FOR KINESITHERAPY – PRELIMINARY REPORT

2020 ◽  
Vol 25 (1) ◽  
pp. 50-54
Author(s):  
Maciej Abakumow ◽  
◽  
Krzysztof Kowalczuk ◽  
Keyword(s):  
Blood Pressure ◽  
Healthy Volunteers ◽  
High Altitude ◽  
Cardiovascular System ◽  
Preliminary Report ◽  
Pressure Increase ◽  
Blood Pressure Increase ◽  
Safety Considerations ◽  
Very High

Abstract: Apart from protection from very high altitude or influence of increased gravitational accelerations protective suits sometimes are used for another applications like supporting kinesitherapy. Because of some safety considerations connected with possible cardiovascular system overload and dangerous blood pressure increase we tested if these concerns are valid. Main aim ot presented research performed with participation of healthy volunteers was to confirm that use of High Altitude Protection (HAP) suit is safe in terms of increased cardiovascular.

Abstract MP09: Vascular Rho-kinase Activation by Inflammatory Signaling Mediates Blood Pressure Increase in Overweight

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Cristiane Aoqui Aoqui ◽  
Stefan Chmielewski ◽  
Uwe Heemann ◽  
Marcus Baumann
Keyword(s):  
Blood Pressure ◽  
Kinase Activity ◽  
Rho Kinase ◽  
Normal Weight ◽  
Mesenteric Arteries ◽  
Pressure Increase ◽  
Tnf Alpha ◽  
Kinase Activation ◽  
Blood Pressure Increase ◽  
Tlr4 Ligand

Background: Overweight is associated with a high prevalence of hypertension. The mechanisms linking overweight to blood pressure increase remain unclear. We hypothesized that vascular Rho-kinase activation contributes to blood pressure increase in overweight by involving TNF-α and TLR4. Methods: C57/BL6 mice fed a high-fat diet for 2 weeks were used to induce overweight associated blood pressure increase. Additional treatment in overweight and normal weight mice contained Rho-kinase inhibitors (fasudil and pravastatin; n=7/all groups), etanercept and TNFR1 and TLR4 null-mice. Microvascular studies were performed in a wire myograph and arterial blood pressure measured with a carotid catheter. Rho-kinase activity was determined in small mesenteric arteries of all groups. Inflammatory ligands such as TNF-alpha and free fatty acids were determined. Effects of TNF-alpha and TLR4 ligand LPS and palmitic acid on Rho-kinase activity and were determined ex vivo in mesenteric arteries and in in vivo. Results: Overweight mice had higher blood pressure (Delta: 9±2 mmHg) and vasoconstriction as normal weight mice. Small mesenteric arteries of overweight mice had a 50% higher Rho-kinase activity as normal weight mice. Ex vivo treatment with the Rho-kinase inhibitor Y-27632 reversed vasoconstriction of mesenteric arteries of overweight mice to constriction level in normal weight mice. In vivo treatment with the Rho-kinase inhibitor fasudil or pravastatin along with high-fat diet abolished the overweight associated blood pressure increase and enhanced vasoconstriction. TNF-alpha and TLR4 ligand free fatty acid were enhanced in overweight mice. TNF-alpha and TLR4 ligand LPS and palmitic acid increased Rho-kinase activity in mesenteric arteries. Use of etenercept, TNFR1 and TLR4 null-mice in the overweight model prevented blood pressure increase, vasoconstriction and Rho-kinase activation. All described effects were independent of adiposity. Conclusion: These results indicated that in diet-induced overweight vascular Rho-kinase activation is a key element of increased blood pressure and vasoconstriction. Potential activator of Rho-kinase are mediated by inflammatory factors including TLR4 ligands and TNF-alpha.

scholarly journals Recurrent Blood Pressure Rise after Treatment with Anti-vascular Endothelial Growth Factor Agents

2020 ◽  
Vol 237 (04) ◽  
pp. 454-457
Author(s):  
Iris Wyssmüller ◽  
Karen Schaal ◽  
Sebastian Wolf ◽  
Martin Zinkernagel
Keyword(s):  
Blood Pressure ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Increase ◽  
Vascular Endothelial ◽  
Blood Pressure Increase ◽  
Injection Process ◽  
Endothelial Growth Factor

Abstract Background It has previously been shown that the process of anti-vascular endothelial growth factor (VEGF) injections can lead to a significant increase of blood pressure. The aim of this study was to investigate whether this blood pressure increase was reproducible with repeated anti-VEGF injections. Patients and Methods Patients with a systolic blood pressure of ≥ 180 mmHg during previous injections who were scheduled for further injections were asked to participate in this study. Systolic as well as diastolic blood pressure was measured before, during, and after the intravitreal injection process. Results Thirty-nine patients (21 females, 18 males) with a mean age of 75 years (range 34 – 94 years) were included in this extension of the FEAR study. At first, clinical systolic blood pressure rose from an average of 157.3 ± 5.9 mmHg to 175 ± 6.7 mmHg at the time of the injection process (p < 0.01). Diastolic blood pressure rose from an average of 75.72 ± 4.2 mmHg to 84.44 ± 7.3 mmHg (p < 0.13) at the time of the injection process. Overall, the majority of the participants (56%, N = 22) had a systolic blood pressure of ≥ 180 mmHg. Conclusions Our results show that the blood pressure increase occurs persistently during the injection process in some patients. Repeated episodes of severe hypertension may predispose patients to cardiovascular events, especially those with concomitant cardiovascular risk factors.

Sign in / Sign up

Export Citation Format

Share Document