Perioperative Risk Factors of Atrial Fibrillation Post CABG Surgeries, a Retrospective Non-Randomized Study

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohsen Abdel Karim ◽  
Ahmed Helmy Omar ◽  
Tamer El-Shahat Hikal ◽  
Hazem Mohamed Youssef

Abstract Background Atrial fibrillation represents a common complication after coronary artery bypass and valvular surgery, although it is a benign arrhythmia it may contribute to the morbidity, high cost and prolonged ICU stay. Objectives The purpose of this study is to investigate and analyze the incidence and risk factors associated with postoperative atrial fibrillation (POAF) and its impact on intensive care unit (ICU) and postoperative hospital stay in patients undergoing coronary artery bypass graft surgeries (CABG) at Ain Shams University hospitals using the medical records of patients who underwent(CABG) surgeries from July 2018 to July 2019. Patients and Methods Our study was conducted in Ain Shams University hospitals from July 2018 to July 2019. This study was a retrospective non randomized on total 660 patients who undergone isolated Coronary artery bypass graft surgeries (CABG) during this period, of them we targeted 100 cases who developed POAF after surgery. Results Our results show that age, history of hypertension,smoking,history of renal impairment and recent myocardial infarction were all predictors of atrial fibrillation after cardiac surgery. POAF developed more frequent in patients who had larger left atrium diameter and lower ejection fraction. Our present results indicate that there is significant association between longer bypass and cross clamping time and development of POAF. We also found that patients who had postoperative lower serum potassium experienced more frequent POAF than who had normal potassium levels. In our study, we found that use of preoperative beta blocking drugs reduces risk of developing POAF. Early electrocardiographic ischemic postop. changes was also associated with high risk to develop POAF. No significant relation between use of intra-aortic balloon pump and development of POAF. Also, no significant relation between POAF and development of stroke or thromboembolic manifestations as POAF is usually self limiting,transient and resolves spontaneously in most of cases. Conclusion The current study found that low ejection fraction, dilated left atrium, hypertension, smoking, old age, male gender, prolonged bypass time, prolonged cross clamping time, renal impairment, previous myocardial infarction, ungrafted dominant right coronary artery, low temperatures on bypass, early ischemic changes postoperative, hypokalemia, use of adrenaline and nor adrenaline, all of these factors were a significant predictors for development of atrial fibrillation after cardiac surgery.

2018 ◽  
Vol 29 (8) ◽  
pp. 543-550 ◽  
Author(s):  
Jungsun Lee ◽  
Insil Jang

The aim of this study is to investigate the differences in POAF (postoperative atrial fibrillation) and non-POAF patients using demographic and clinical characteristics and identify predictors affecting POAF after coronary artery bypass grafts in South Korea. This retrospective cohort study included 999 patients followed-up for at least 1 year after coronary artery bypass graft, between January 2011 and December 2015. Multivariate logistic regression was performed to assess risk factors based on demographics, as well as preoperative and postoperative characteristics. The adjusted multivariate analysis demonstrated that risk factors for POAF were old age (⩾65 years; odds ratio [OR] = 3.022, p < .001), ejection fraction less than 45% (OR = 1.489, p = .036), electrolyte potassium level after surgery (OR = 1.765, p = .003), and the average pain score on Postoperative Day 1 (OR = 1.253, p < .001). The incidence of atrial fibrillation after coronary artery bypass graft surgery can be reduced through the screening of preoperative risk factors, strict potassium monitoring, and pain management strategies.


2017 ◽  
Vol 8 (2) ◽  
pp. 104-113 ◽  
Author(s):  
Julien Magne ◽  
Baptiste Salerno ◽  
Dania Mohty ◽  
Claire Serena ◽  
Florence Rolle ◽  
...  

Objective: Postoperative atrial fibrillation is a major complication following coronary artery bypass graft. We hypothesized that, beyond clinical and electrocardiogram (ECG) data, transthoracic echocardiography could improve the prediction of postoperative atrial fibrillation. Methods: We prospectively studied 169 patients in sinus rhythm who underwent isolated coronary artery bypass graft in our institution. Clinical, biological, ECG and transthoracic echocardiography data were collected within 24 h before surgery. The patients were continuously monitored during the first five days, and then had daily 12-lead ECG afterwards until discharge. Postoperative atrial fibrillation was defined by any episode >10 min. Results: Postoperative atrial fibrillation was found in 65 patients (38%). Compared with those without, patients with postoperative atrial fibrillation were significantly older ( p=0.008), had more frequently a history of hypertension ( p=0.009), history of atrial fibrillation ( p<0.001) and New York Heart Association class ⩾III ( p=0.004). They also had longer PR interval ( p=0.005), higher preoperative NT-pro brain natriuretic peptide level ( p=0.006), left ventricle end-diastolic volume ( p=0.002), indexed left ventricle mass ( p<0.0001), indexed maximal left atrial volume ( p<0.0001), maximal right atrial area ( p<0.001) and lower left ventricle ejection fraction ( p=0.04). In multivariate analysis, history of atrial fibrillation (odds ratio =6.1, 95% confidence interval: 1.4–26.0, p=0.02) and indexed maximal left atrial volume (odds ratio =1.13, 95% confidence interval: 1.1–1.2, p=0.001) were the only two independent predictive factors of postoperative atrial fibrillation. The addition of echocardiographic parameters improved the predictive value (χ2) of the model, from 34 to 57. Conclusion: A history of atrial fibrillation and indexed left atrial maximal volume are the best predictors of the occurrence of postoperative atrial fibrillation following coronary artery bypass graft. The identification of high risk population of postoperative atrial fibrillation using these two factors could lead to the development of targeted strategies to limit this frequent complication in these patients.


2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
O Rubanenko ◽  
Y Shchukin ◽  
A Rubanenko

Abstract Purpose To estimate the association of the genetic polymorphisms of Interleukin-6 (IL-6) and Interleukin-10 (IL-10) with new onset atrial fibrillation (AF) in postoperative period of coronary artery bypass graft (CABG) surgery in patients with coronary artery disease (CAD). Methods Studied were 158 patients who underwent CABG. In all the patients routine laboratory and instrumental tests were performed. Patients also underwent genetic polymorphisms of IL-6 C174G, IL-10 C592A and IL-10 G1082A estimation. All the patients were divided into two groups: 1 group comprised 111 patients without AF (82.0% men, median age 62.0 (56.0; 66.0) years, 2 group - 47 patients with AF development after CABG (84.4% men, median age 65.0 (61.0; 70.0) years). Results During the observation period AF occurred in 29.7% patients, on average 5.2 (2.0; 7.0) days after surgery. Patients of group 2 had longer history of CAD (60.0 (13.5; 138.0) vs. 15.5 (8.0; 72.0) months, p=0.01), had more often NYHA III class (27.7% vs. 9.0%, p=0.002) and larger left atrial (LA) diameter (44.0 (40.5; 46.0) mm vs. 38.0 (36.0; 40.0) mm, p&lt;0.0001) comparing with group 1. Genotype CC IL-6 C174G was found in 19.8% patients of the 1 group and in 25.5% patients of the 2 group (p=0.42), genotype CG - in 56.8% and 53.2% (p=0.68), genotype GG - in 23.4% and 21.3% (p=0.77) respectively. Genotype CC IL-10 C592A was found in 62.2% patients of the 1 group and 46.8% patients of the 2 group (p=0.29), genotype CA - in 37.8% patients of the 1 group and in 53.2% patients of the 2 group (p=0.07) respectively. Genotype GG IL-10 G1082A was found in 25.2% patients of the 1 group and 23.4% patients of the 2 group (p=0.8), genotype GA - in 48.6% patients of the 1 group and in 59.6% patients of the 2 group (p=0.2), genotype AA - in 26.2% patients of the 1 group and in 17.0% patients of the 2 group (p=0.3) respectively. All estimated genotypes fulfilled expectations of Hardy-Weinberg equilibrium. According to the result of multivariate regression analysis the odds ratio for AF development in postoperative period of CABG for history of CAD more than 20 months - 1.1 (95% CI, 1.03–1.2, p=0.04), for LA dimension more than 41 mm - 1.5 (95% CI, 1.28–1.79, p&lt;0.0001). Conclusion Our investigation showed that increased left atrial dimension and the history of coronary artery disease were associated with postoperative atrial fibrillation development in patients who underwent coronary artery bypass graft surgery. However, genetic polymorphisms of IL-6 C174G, IL-10 C592A and IL-10 G1082A were not significantly associated with postoperative atrial fibrillation development. FUNDunding Acknowledgement Type of funding sources: None.


2011 ◽  
Vol 41 (9) ◽  
pp. 995-1003 ◽  
Author(s):  
Gudrun V. Skuladottir ◽  
Ragnhildur Heidarsdottir ◽  
David O. Arnar ◽  
Bjarni Torfason ◽  
Vidar Edvardsson ◽  
...  

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