Effect of Central Dialysis Fluid Delivery System (CDDS) on IL6 & CRP Levels in Prevalent Haemodialysis Patients

Abstract Background Dialysis is a chronic inflammatory state due to both decreased renal clearance and increased production of procytokines, moreover extracorporeal factors, such as impurities in dialysis water,etc. The central dialysis fluid delivery system (CDDS) is a cost-effective, laborsaving, time-tested system with good microbial safety, which has been used for 45 years in many countries & this study, studies the effect of (CDDS) on IL6 & hs-CRP levels in prevalent hemodialysis patients. Aim of the Work To compare the effect of central dialysis fluid delivery system (CDDS) versus single-patient dialysis fluid delivery system (SPDDS) in purification of water that used in dialysate and its effect on inflammatory markers (hs-CRP & IL-6) levels in prevalent hemodialysis patients. Patients and Methods A Case control study that was conducted on 100 patients of end-stage renal disease on hemodialysis in a university-affiliated hospital. Patients were classified into two groups, each included 50 patients; group (1) receiving regular dialysis by central dialysis fluid delivery system (CDDS), while group (2) receiving regular dialysis by single patient dialysis fluid delivery system (SPDDS) . Patients underwent full clinical assessment including thorough history taking, clinical examination, routine investigation, IL-6 and hsCRP testing to all patients. Results One hundred prevalent hemodialysis patients were included in this study. In this study, the levels of IL-6 and hs-CRP were found to be significantly higher in group 2 (SPDS) as compared to group 1 (CDDS). Conclusion In conclusion, central dialysis fluid delivery system (CDDS) seems to have a better effect on systemic inflammation (IL-6 and hsCRP) as compared with single-patient dialysis fluid delivery system (SPDDS). There is a statistically negative correlation between serum IL-6 and hsCRP levels with dry weight, Hemoglobin level, serum creatinine level & serum albumin level for group (1) (CDDS). However, there is a statistically positive correlation between serum IL-6 and hsCRP levels with Total Leuckocytic Count (TLC), serum ferritin level, serum potassium level, weight gain and duration of dialysis for group (2) (SPDS).

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Characteristics of Central Dialysis Fluid Delivery System and Single Patient Dialysis Machine for HDF

Contributions to Nephrology - Hemodiafiltration - A New Era ◽

10.1159/000321748 ◽

2010 ◽

pp. 99-106

Author(s):

Ikuo Aoike

Keyword(s):

Delivery System ◽

Single Patient ◽

Dialysis Fluid ◽

Fluid Delivery

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The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients

Blood Purification ◽

10.1159/000515639 ◽

2021 ◽

pp. 1-7

Author(s):

Emre Erdem ◽

Ahmet Karatas ◽

Tevfik Ecder

Keyword(s):

Serum Ferritin ◽

Hemodialysis Patients ◽

Rank Test ◽

Significant Difference ◽

All Cause Mortality ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. Methods: A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: serum ferritin <800 ng/mL, group 2: serum ferritin 800–1,500 ng/mL, and group 3: serum ferritin >1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. Results: Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5–60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, p = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05–0.49]; p = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12–0.88]; p = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23–1.04]; p = 0.063). Conclusion: Time-averaged serum ferritin levels >1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.

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Postoperative Pain Control with a New Transdermal Fentanyl Delivery System

Anesthesiology ◽

10.1097/00000542-199509000-00005 ◽

1995 ◽

Vol 83 (3) ◽

pp. 470-477. ◽

Cited By ~ 17

Author(s):

Rafael Miguel ◽

Joel M. Kreitzer ◽

Douglas Reinhart ◽

Peter S. Sebel ◽

Julius Bowie ◽

...

Keyword(s):

Postoperative Pain ◽

Delivery System ◽

Pain Control ◽

Fentanyl Patch ◽

Postoperative Pain Control ◽

Transdermal Fentanyl ◽

Placebo Patch ◽

Group 3 ◽

Group 2 ◽

Group 1

Background A new transdermal delivery system for fentanyl is available in two strengths: 70-80 and 90-100 micrograms.kg-1.h-1 (40- and 60-cm2 patches, respectively). Their short onset and 24-h drug delivery make them attractive for postoperative pain control. Methods Both doses of the new transdermal fentanyl patches were evaluated for the relief of postoperative pain in 143 patients after gynecologic exploratory laparotomy. The study was conducted at four centers using a prospective, randomized, placebo-controlled, double-blind format. Patients were randomly assigned to one of three study groups: group 1 patients received two placebo patches: group 2 patients received a 40-cm2 fentanyl patch and a 60-cm2 placebo patch; and group 3 patients received a 60-cm2 fentanyl patch and a 40-cm2 placebo patch. Patient-controlled morphine use and pain, sedation, and comfort scores were assessed postoperatively every 4 h for 36 h after patch placement. Results Patients' assessment of their analgesia was significantly (P < or = 0.05) better in group 2 at 16 and 24 h and in group 3 at 8, 12, 16, 20, and 24 h postoperatively, compared with the patients in group 1. Patients in groups 2 and 3 required less supplemental morphine to maintain satisfactory analgesia than did the patients in group 1. Patients in groups 2 and 3 had greater incidences of pruritus, erythema, and respiratory depression than did those receiving placebo. Conclusions Concern exists regarding the side effects of this this new transdermal fentanyl patch. Therefore, this new patch will need further research before it can be recommended as an adjunct in controlling postoperative pain.

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Dialysate Purification After Introduction of Automated Hot Water Disinfection System to Central Dialysis Fluid Delivery System

ASAIO Journal ◽

10.1097/mat.0b013e318241f506 ◽

2012 ◽

pp. 1 ◽

Cited By ~ 2

Author(s):

Tomonari Ogawa ◽

Akihiko Matsuda ◽

Yumiko Yamaguchi ◽

Yusuke Sasaki ◽

Yuki Kanayama ◽

...

Keyword(s):

Delivery System ◽

Hot Water ◽

Water Disinfection ◽

Dialysis Fluid ◽

Fluid Delivery

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Current Status and Perspective of the Dialysis Fluid Delivery System in Relation to Dialysis Fluid Purification

10.1159/isbn.978-3-8055-9180-5 ◽

2009 ◽

Keyword(s):

Delivery System ◽

Current Status ◽

Dialysis Fluid ◽

Fluid Delivery

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Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients

Scientific Reports ◽

10.1038/s41598-019-52498-7 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Juliana de Fatima Pedroso ◽

Zahra Lotfollahi ◽

Ghadeer Albattarni ◽

Maiara Arrruda Schulz ◽

Andrea Monteiro ◽

...

Keyword(s):

Diabetes Mellitus ◽

Total Cholesterol ◽

Periodontal Therapy ◽

Optical Measurements ◽

Diabetic Patients ◽

Clinical Parameters ◽

Periodontal Debridement ◽

Group 2 ◽

Hs Crp ◽

Group 1

Abstract The objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supra-gingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline, t = 6 and t = 12 months after treatment. Solutions of LDL were analyzed using the nonlinear optical Z-Scan and optical absorption techniques. The periodontal clinical parameters showed significant improvement (p < 0.05) in both Group after 12 months. For both groups, total cholesterol, HDL-c, LDL-c, triglycerides and A1c levels did not show significant reductions after periodontal therapy. hs-CRP levels in Group 1 presented a significant reduction after 12 months. The glycemic rate and the oxLDL concentrations did not show significant differences as a function of time. The optical measurements of LDL solutions revealed an improvement of the LDL-c quality in both groups. Periodontal debridement was able to improve periodontal parameters and the quality of LDL-c in diabetic patients but without changes in the oxLDL concentration in both groups. Considering the clinical relevance, the reduction of infectious and inflammatory sites present in the oral cavity through periodontal therapy may help with the control and prevention of hyperglycemia and precursors of cardiovascular diseases.

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Efficacy of Clopidrogel on Reperfusion and High-Sensitivity C-Reactive Protein in Patients with Acute Myocardial Infarction

Mediators of Inflammation ◽

10.1155/2009/932515 ◽

2009 ◽

Vol 2009 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Mehmet Akbulut ◽

Makbule Kutlu ◽

Yılmaz Ozbay ◽

Veli Polat ◽

Mehmet Nail Bilen ◽

...

Keyword(s):

Therapy Group ◽

High Sensitivity ◽

Reperfusion Therapy ◽

Early Reperfusion ◽

Unfractioned Heparin ◽

Reactive Protein ◽

St Segment ◽

Group 2 ◽

Hs Crp ◽

Group 1

We investigated the effects of clopidogrel on reperfusion and inflammatory process in STEMI. A total of 175 STEMI patients with similar clinical characteristics were included to this study. One was the standard pharmacological reperfusion therapy group (group 1,n: 90), who received 300 mg aspirin, 70 U/kg bolus, and 12 U/kg/hr continuous infusion of unfractioned heparin and accelerated t-PA. Clopidogrel 450 mg loading and 75 mg/d thereafter was added to standard reperfusion therapy in the other group (group 2,n: 85). The ST-segment resolution, CK-MB, and high-sensitive CRP (hs-CRP) parameters were measured. Complete ST resolution was observed in 32 patients (36.8%) in group 1 and 53 patients (63.8%) in group 2 (). Also in the first 24 hours, the CK-MB levels of patients in group 1 were significantly higher than those of group 2 (). The hs-CRP values were greater in group 1 than group 2 at 48th hour (gruop 1: mg/L, group 2: mg/L; ). We concluded that adding clopidogrel to standard treatment in STEMI patients provided early reperfusion and suppression of inflammatory response.

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