Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA

Objective To explore the association between carotid plaque and lumbar spine osteoporosis in post-menopausal women. Study design Age-matched, cross-sectional study. Main outcome measures Carotid plaque and carotid intima media thickness were measured with B-mode ultrasound. Lumbar spine bone mineral density was measured with dual-energy X-ray absorptiometry. Prevalence odds ratios and the respective 95% confidence intervals (95%CI) were calculated to determine the association. Results Seventy-two post-menopausal women with lumbar spine osteoporosis and 72 post-menopausal women with normal lumbar spine bone mineral density were enrolled. The adjusted prevalence odds ratio of carotid plaque presence in post-menopausal women with lumbar spine osteoporosis was 1.73 (95%CI; 0.60 to 4.94) when compared to post-menopausal women with normal lumbar spine bone mineral density. The presence of vulnerable plaque was greater in post-menopausal women with lumbar spine osteoporosis; however, the difference was not statistically significant after adjusting for other risk factors of cardiovascular disease (odds ratio 1.31; 95%CI; 0.39 to 4.43). There was no significant difference in carotid intima media thickness between the two groups. Multiple logistic regression analysis with backward elimination in assessment of potential risk factors for the presence of carotid plaque showed that the year since menopause, family history of cardiovascular disease and systolic blood pressure were nominally significant associated factors with a respective adjusted odds ratio of 1.06 (95%CI; 1.01 to 1.12), 6.23 (95%CI; 1.65 to 23.46) and 1.03 (95%CI; 1.01 to 1.06). Conclusions The current study indicates that lumbar spine osteoporosis is not associated with the presence of carotid plaque, whereas year since menopause, family history of cardiovascular disease and systolic blood pressure are associated factors.

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The Effect of Dietary Protein and Amino Acid Intake on Total Hip and Lumbar Spine Bone Mineral Density Measurements

Journal of the Academy of Nutrition and Dietetics ◽

10.1016/j.jand.2021.06.093 ◽

2021 ◽

Vol 121 (9) ◽

pp. A33

Author(s):

K. Steiner ◽

M. Jackson ◽

J. Wells ◽

M. Timmerman ◽

L. Bilek ◽

...

Keyword(s):

Bone Mineral Density ◽

Amino Acid ◽

Lumbar Spine ◽

Bone Mineral ◽

Dietary Protein ◽

Spine Bone Mineral Density ◽

Mineral Density ◽

Density Measurements ◽

Total Hip ◽

Amino Acid Intake

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Brisk Walking Reduces Calcaneal Bone Loss in Post-Menopausal Women

Clinical Science ◽

10.1042/cs0920075 ◽

1997 ◽

Vol 92 (1) ◽

pp. 75-80 ◽

Cited By ~ 44

Author(s):

Katherine Brooke-Wavell ◽

Peter R. M. Jones ◽

Adrianne E. Hardman

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Loss ◽

Femoral Neck ◽

Bone Mineral ◽

Brisk Walking ◽

Mineral Density ◽

Control Subjects ◽

Menopausal Women ◽

Post Menopausal

1. This study examined the influence of brisk walking on skeletal status in post-menopausal women. 2. Subjects were 84 healthy women aged 60–70 years who were previously sedentary and at least 5 years post-menopausal. Subjects were randomly assigned to walking (n = 43) and control (n = 41) groups. Walkers followed a 12-month, largely unsupervised programme of brisk walking. The bone mineral density of the lumbar spine, femoral neck and calcaneus and broadband ultrasonic attention of the calcaneus were measured at baseline and after 12 months. 3. Forty control subjects and 38 walkers completed the study. Walkers built up to 20.4 ± 3.8 min/day (mean ± SD) of brisk walking. Body mass increased in control subjects relative to walkers [mean change (SE) ± 0.9 (0.3) and −0.1 (0.3) kg respectively; P = 0.04]. Predicted maximum oxygen uptake increased in walkers by 2.1 (0.9) ml min−1 kg−1 (P = 0.02). Bone mineral density in the lumbar spine and calcaneus fell in control subjects [–0.005 (0.004) and −0.010 (0.004) g/cm2, respectively] but not in walkers [+0.006 (0.004) and +0.001 (0.004) g/cm2]. The difference in response between groups was significant in the calcaneus (P = 0.04) but not in the lumbar spine (P = 0.08). Mean femoral neck bone mineral density did not change significantly in either group, although changes in walkers were related to the amount of walking completed (r = 0.51, P = 0.001). The change in broadband ultrasonic attenuation of the calcaneus differed between groups [control subjects, −3.7 (0.8); walkers, −0.7 (0.8) dB/MHz; P = 0.01]. 4. Walking decreased bone loss in the calcaneus and possibly in the lumbar spine. It also improved functional capacity and enabled walkers to avoid the increase in body mass seen in control subjects.

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Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women

The Open Rheumatology Journal ◽

10.2174/1874312901812010001 ◽

2018 ◽

Vol 12 (1) ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Sawsan Jaghsi ◽

Taghrid Hammoud ◽

Shaden Haddad

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Serum Vitamin ◽

Vitamin K1 ◽

Mineral Density ◽

Post Menopausal Osteoporosis ◽

Menopausal Women ◽

Healthy Control ◽

Post Menopausal

Background: In the past two decades, Vitamin K has been receiving more attention due to its role in bone health and metabolism. The bone mineral density does not remain steady with age, particularly declining after menopause. Objective: This study is aimed to investigate the relationship between bone mineral density and serum vitamin K1 levels in post-menopausal women, and to evaluate serum vitamin K1 levels as a potential biomarker for postmenopausal osteoporosis. Methods: Serum levels of vitamin k1 were measured in 23 postmenopausal osteoporotic women, and in 15 postmenopausal healthy control women using a standardized Enzyme-Linked Immune Sorbent Assay (ELISA) kit. Bone mineral density BMD was assessed at the lumbar spine. Results: The mean serum vitamin k1 level was significantly lower in the postmenopausal osteoporotic women group than in the normal control group (mean=0.794 vs3.61ng/ml, P< 0.0001), and serum vitamin k1 concentration was positively correlated with lumbar spine BMD among postmenopausal osteoporotic women (R=0.533, p = 0.009), and in postmenopausal healthy control (R=0.563, p = 0.02). Diagnostic sensitivity and specificity of vitamin k1 for osteoporosis were 90% and 98%, respectively (cut-off value: 0.853 ng/ml). The area under the ROC curve (AUC) value for vitamin k1 was 0.984 the odd ratio result was 18.66. Conclusion: Our results suggest that vitamin K1 may contribute to maintain bone mineral density. Vitamin K1 may have a role in diagnosing post-menopausal osteoporosis. Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.

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CORRELATION OF BONE MINERAL DENSITY AT THE LUMBAR SPINE AND HIP WITH PARAMETERS OF SKELETAL TURNOVER IN POST-MENOPAUSAL WOMEN

Southern Medical Journal ◽

10.1097/00007611-199610001-00102 ◽

1996 ◽

Vol 89 (Supplement) ◽

pp. S55

Author(s):

Farhana Asad ◽

Matthew Tayback ◽

Jay Shapiro

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Mineral Density ◽

Menopausal Women ◽

Post Menopausal

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Low bone mineral density in noncholestatic liver cirrhosis: prevalence, severity and prediction

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032003000300004 ◽

2003 ◽

Vol 40 (3) ◽

pp. 152-158 ◽

Cited By ~ 4

Author(s):

Fátima Aparecida Ferreira Figueiredo ◽

Cynthia Brandão ◽

Renata de Mello Perez ◽

Walnei Fernandes Barbosa ◽

Mario Kondo

Keyword(s):

Bone Mineral Density ◽

Liver Disease ◽

Lumbar Spine ◽

Bone Density ◽

Bone Mineral ◽

Laboratory Tests ◽

Mineral Density ◽

Low Bone Mineral Density ◽

Menopausal Women ◽

Post Menopausal

BACKGROUND: Metabolic bone disease has long been associated with cholestatic disorders. However, data in noncholestatic cirrhosis are relatively scant. AIMS: To determine prevalence and severity of low bone mineral density in noncholestatic cirrhosis and to investigate whether age, gender, etiology, severity of underlying liver disease, and/or laboratory tests are predictive of the diagnosis. PATIENTS/METHODS: Between March and September/1998, 89 patients with noncholestatic cirrhosis and 20 healthy controls were enrolled in a cross-sectional study. All subjects underwent standard laboratory tests and bone densitometry at lumbar spine and femoral neck by dual X-ray absorptiometry. RESULTS: Bone mass was significantly reduced at both sites in patients compared to controls. The prevalence of low bone mineral density in noncholestatic cirrhosis, defined by the World Health Organization criteria, was 78% at lumbar spine and 71% at femoral neck. Bone density significantly decreased with age at both sites, especially in patients older than 50 years. Bone density was significantly lower in post-menopausal women patients compared to pre-menopausal and men at both sites. There was no significant difference in bone mineral density among noncholestatic etiologies. Lumbar spine bone density significantly decreased with the progression of liver dysfunction. No biochemical variable was significantly associated with low bone mineral density. CONCLUSIONS: Low bone mineral density is highly prevalent in patients with noncholestatic cirrhosis. Older patients, post-menopausal women and patients with severe hepatic dysfunction experienced more advanced bone disease. The laboratory tests routinely determined in patients with liver disease did not reliably predict low bone mineral density.

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