Interaction between oxidative stress and smoking is associated with an increased risk of rheumatoid arthritis: a case-control study

Abstract Background and aim A number of studies have investigated the effects of individual foods and/or nutrients on rheumatoid arthritis (RA), but research focusing on whole dietary patterns remains limited. The association of dietary patterns and rheumatoid arthritis is therefore not well elucidated. This study aims to determine existing relationships between major identified dietary patterns and RA. Methods This matched case–control study was conducted on 297 individuals in Isfahan, Iran. The presence of RA was determined by an expert rheumatologist, based on the American College of Rheumatology definitions, 2010. A 168-item questionnaire was used to collect dietary data. Major dietary patterns were identified using the factor analysis method. Results Two major dietary patterns, namely, healthy and western dietary patterns, were identified. Lower adherence to the healthy dietary pattern was associated with increased risk of RA (OR = 2.80; 95% CI 1.74–4.67; P < 0.001). The association remained significant even after taking other confounders into account (OR = 2.85; 95% CI 1.12–7.45; P = 0.03). A positively significant association was also observed between adherence to western dietary pattern and RA in the fully-adjusted final model (OR = 2.22; 95% CI 1.04–4.72; P = 0.03). Conclusions The study suggests that there is an inverse association between adherence to a healthy dietary pattern and the odds of RA, and a positive significant relationship was found between western dietary pattern and RA. Further studies are required to confirm these findings.

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Oxidative Stress and Polymorphism in MTHFR SNPs (677 and 1298) in Paternal Sperm DNA is Associated with an Increased Risk of Retinoblastoma in Their Children: A Case–Control Study

Journal of Pediatric Genetics ◽

10.1055/s-0038-1667037 ◽

2018 ◽

Vol 07 (03) ◽

pp. 103-113 ◽

Cited By ~ 2

Author(s):

Shilpa Bisht ◽

Bhavna Chawla ◽

Rima Dada

Keyword(s):

Oxidative Stress ◽

Case Control Study ◽

Case Control ◽

Mthfr Gene ◽

Nucleotide Polymorphisms ◽

Mthfr Polymorphisms ◽

Sperm Dna ◽

Increased Risk ◽

Control Study

AbstractSperm DNA is considered as the most vulnerable to oxidative stress-induced damage that also impairs global sperm DNA methylation leading to sperm-associated pathologies. C677T and A1298C polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene affect MTHFR enzyme activity. This study was planned as a case–control study to determine the MTHFR gene polymorphisms in the fathers of children affected with sporadic nonfamilial heritable retinoblastoma in an Indian population. MTHFR polymorphisms for single nucleotide polymorphisms 677 and 1298 were also determined in sporadic nonfamilial heritable retinoblastoma patients to estimate the risk for retinoblastoma development and to evaluate the role of MTHFR in retinoblastoma pathogenesis.

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Physical workload is associated with increased risk of rheumatoid arthritis: results from a Swedish population-based case–control study

RMD Open ◽

10.1136/rmdopen-2016-000324 ◽

2017 ◽

Vol 3 (1) ◽

pp. e000324 ◽

Cited By ~ 5

Author(s):

Pingling Zeng ◽

Lars Klareskog ◽

Lars Alfredsson ◽

Camilla Bengtsson

Keyword(s):

Rheumatoid Arthritis ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Physical Workload ◽

Swedish Population ◽

Increased Risk ◽

Control Study

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Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study

PeerJ ◽

10.7717/peerj.5509 ◽

2018 ◽

Vol 6 ◽

pp. e5509 ◽

Cited By ~ 1

Author(s):

Mohini A. Tupurani ◽

Chiranjeevi Padala ◽

Kaushik Puranam ◽

Rajesh K. Galimudi ◽

Keerthi Kupsal ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Case Control Study ◽

Case Control ◽

Breast Cancer Patients ◽

Functional Polymorphisms ◽

Increased Risk ◽

Cancer Initiation ◽

Control Study ◽

Cyba Gene

Background Oxidative stress (OS) is a key characteristic feature in cancer initiation and progression. Among multiple cancers, NADPH oxidase (NOX) dependent free radical production is implicated in oxidative stress. P22phox, a subunit of NADPH oxidase encoded by the CYBA gene has functional polymorphisms associated with various complex diseases. The present study was aimed to examine the importance and association of the functional polymorphisms of CYBA gene (-930 A/G and 242 C/T) with the oxidative stress in breast cancer (BC) development and progression. Materials and Methods We have performed a case-control study on 300 breast cancer patients and 300 healthy individuals as controls to examine the role of CYBA gene -930 A/G and 242 C/T single nucleotide polymorphisms (SNPs) using As-PCR and PCR-RFLP assays and its association with OS as measured by plasma MDA levels. Linkage disequilibrium (LD) plots were generated using Haploviewtool and Multifactor dimensionality reduction (MDR) analysis was applied to assess high-order interactions between the SNPs. The Insilco analysis has been performed to predict the effect of SNPs on the gene regulation using online tools. Results We have found that genotype frequencies of CYBA gene -930 A/G and 242C/T polymorphism were significantly different between controls and BC patients (p < 0.05). The haplotype combination -930G/242C and -930G/242T were associated with 1.44 & 1.56 folds increased risk for breast cancer respectively. Further, the MDA levels were higher in the patients carrying -930G/242C and -930G/242T haplotype (p < 0.001). Our results have been substantiated by Insilco analysis. Conclusion Results of the present study suggest that GG genotype of -930 A/G polymorphism, -930G/242C and -930G/242T haplotypes of CYBA gene polymorphisms have shown association with higher MDA levels in breast cancer patients, signify that elevated oxidative stress might aid in increased risk for breast cancer initiation and progression.

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Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-208278 ◽

2015 ◽

Vol 75 (6) ◽

pp. 997-1002 ◽

Cited By ~ 41

Author(s):

Chun Lai Too ◽

Nor Asiah Muhamad ◽

Anna Ilar ◽

Leonid Padyukov ◽

Lars Alfredsson ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Occupational Exposure ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Dust Exposure ◽

Environment Interaction ◽

Malaysian Population ◽

Increased Risk ◽

Control Study

ObjectivesLung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). We investigated the association between textile dust exposure and the risk of RA in the Malaysian population, with a focus on women who rarely smoke.MethodsData from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis population-based case–control study involving 910 female early RA cases and 910 female age-matched controls were analysed. Self-reported information on ever/never occupationally exposed to textile dust was used to estimate the risk of developing anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. Interaction between textile dust and the human leucocyte antigen DR β-1 (HLA-DRB1) shared epitope (SE) was evaluated by calculating the attributable proportion due to interaction (AP), with 95% CI.ResultsOccupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).ConclusionsThis is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA.

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Smoking is associated with an increased risk of developing ACPA-positive but not ACPA-negative rheumatoid arthritis in Asian populations: evidence from the Malaysian MyEIRA case–control study

Modern Rheumatology ◽

10.3109/s10165-011-0544-2 ◽

2012 ◽

Vol 22 (4) ◽

pp. 524-531 ◽

Cited By ~ 21

Author(s):

Abqariyah Yahya ◽

Camilla Bengtsson ◽

Too Chun Lai ◽

Per T. Larsson ◽

Amal Nasir Mustafa ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Case Control Study ◽

Case Control ◽

Asian Populations ◽

Increased Risk ◽

Control Study

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Genetic Variations in Genes Encoding RANK, RANKL, and OPG in Rheumatoid Arthritis: A Case-Control Study

The Journal of Rheumatology ◽

10.3899/jrheum.091110 ◽

2010 ◽

Vol 37 (5) ◽

pp. 900-904 ◽

Cited By ~ 24

Author(s):

GUNTER ASSMANN ◽

JOCHEM KOENIG ◽

MICHAEL PFREUNDSCHUH ◽

JOERG T. EPPLEN ◽

JOERN KEKOW ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Structural Damage ◽

Case Control Study ◽

Case Control ◽

Genetic Variations ◽

Minor Allele ◽

Taqman Assay ◽

Systemic Autoimmune Disease ◽

Increased Risk ◽

Control Study

Objective.Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints, which may lead to structural damage of the cartilage and bone. The receptor activator of nuclear factor-κB (RANK) and the osteoprotegerin (OPG) cascade system have been reported to be essential in osteoclastogenesis. Genetic variations in the genes coding for RANK, RANK ligand (RANKL), and OPG are thought to play roles in the susceptibility to RA.Methods.In our case-control study, genomic DNA was obtained from 534 patients with RA who fulfilled the American College of Rheumatology 1987 criteria and 516 healthy control blood donors (HC). We studied 7 single-nucleotide polymorphisms (SNP) in the genes of RANK (2 SNP: rs1805034, rs35211496), OPG (2 SNP: rs3102735, rs2073618), and RANKL (3 SNP: rs9533156, rs2277438, rs1054016) using TaqMan assay-guided polymerase chain reaction. Genotype and allelic frequencies comparing RA patients with HC were analyzed by chi-square test for 2 × 3 and 2 × 2 tables, respectively.Results.Genotype distributions of the SNP rs35211496 in the RANK gene as well as the SNP rs2277438 in the RANKL gene differed significantly between patients with RA and HC. The frequency of the minor allele of rs9533156 of RANKL was significantly higher in patients with RA than in HC (OR 0.84, 95% CI 0.71–0.99, p = 0.047). Multivariate analysis adjusted to sex and investigating SNP demonstrated a significantly elevated risk for RA associated with the major allele in the RANK SNP rs35211496 (p = 0.0231) and with the minor allele in the RANKL SNP rs2277438 (p = 0.0092). No significantly increased risk was detected in the other SNP.Conclusion.The minor allele of the RANK SNP rs35211496 may be protective against RA, while the minor alleles of the RANKL SNP rs2277438 may increase susceptibility to RA.

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Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study

Arthritis Research & Therapy ◽

10.1186/s13075-021-02617-5 ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Madeline N. Peterson ◽

Hayley J. Dykhoff ◽

Cynthia S. Crowson ◽

John M. Davis ◽

Lindsey R. Sangaralingham ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Index Date ◽

Case Control Study ◽

Case Control ◽

Statin User ◽

Increased Risk ◽

Statin Prescription ◽

Baseline Coverage ◽

Control Study ◽

Statin Use

Abstract Objective To evaluate the association between statin use and the risk of developing rheumatoid arthritis (RA) in a large, US case-control study. Methods Using the OptumLabs Data Warehouse, RA cases were identified as patients aged ≥18 years with ≥2 RA diagnoses between January 1, 2010 and June 30, 2019 and ≥1 prescription fills for methotrexate within 1 year of the first RA diagnosis. The first RA diagnosis was the index date. Cases were matched 1:1 to controls on age, sex, region, year of index date, and length of baseline coverage. Statin users were defined by having ≥2 statin prescription fills at least 90 days pre-index. Patients identified as statin users were further classified by statin user status (current or former), statin use duration, and intensity of statin exposure. Odds ratios for RA risk with statin use were estimated using logistic regression. Results 16,363 RA cases and 16,363 matched controls were identified. Among RA cases, 5509 (33.7%) patients were statin users compared to 5164 (31.6%) of the controls. Statin users had a slightly increased risk of RA compared to non-users (OR 1.12, 95% CI 1.06–1.18), and former statin users had an increased RA risk compared to current users (OR 1.21, 95% CI 1.13–1.28). However, risk was eliminated following adjustment for hyperlipidemia. The risk estimates for statin use duration and intensity did not reach significance. Conclusion This study demonstrates no significant increase in the risk of developing RA for statin users compared to non-users after adjustment for hyperlipidemia in addition to other relevant confounders. However, more information from prospective studies would be necessary to further understand this relationship.

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