Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case–control study

2014 ◽  
Vol 24 (2) ◽  
pp. 271-274 ◽  
Author(s):  
Abqariyah Yahya ◽  
Camilla Bengtsson ◽  
Per Larsson ◽  
Chun Lai Too ◽  
Amal Nasir Mustafa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Asian Population ◽  
Case Control ◽  
Silica Exposure ◽  
Increased Risk ◽  
Control Study

scholarly journals Interaction between oxidative stress and smoking is associated with an increased risk of rheumatoid arthritis: a case-control study

Rheumatology ◽  
2012 ◽  
Vol 52 (3) ◽  
pp. 487-493 ◽  
Author(s):  
V. Navarro-Compan ◽  
E. Melguizo-Madrid ◽  
B. Hernandez-Cruz ◽  
K. Santos-Rey ◽  
C. Leyva-Prado ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

scholarly journals The relationship between dietary patterns and rheumatoid arthritis: a case–control study

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Shokufeh Nezamoleslami ◽  
Reza Ghiasvand ◽  
Awat Feizi ◽  
Mansour Salesi ◽  
Makan Pourmasoumi
Keyword(s):  
Rheumatoid Arthritis ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Case Control Study ◽  
Case Control ◽  
Inverse Association ◽  
Western Dietary Pattern ◽  
Increased Risk ◽  
Control Study ◽  
Healthy Dietary Pattern

Abstract Background and aim A number of studies have investigated the effects of individual foods and/or nutrients on rheumatoid arthritis (RA), but research focusing on whole dietary patterns remains limited. The association of dietary patterns and rheumatoid arthritis is therefore not well elucidated. This study aims to determine existing relationships between major identified dietary patterns and RA. Methods This matched case–control study was conducted on 297 individuals in Isfahan, Iran. The presence of RA was determined by an expert rheumatologist, based on the American College of Rheumatology definitions, 2010. A 168-item questionnaire was used to collect dietary data. Major dietary patterns were identified using the factor analysis method. Results Two major dietary patterns, namely, healthy and western dietary patterns, were identified. Lower adherence to the healthy dietary pattern was associated with increased risk of RA (OR = 2.80; 95% CI 1.74–4.67; P < 0.001). The association remained significant even after taking other confounders into account (OR = 2.85; 95% CI 1.12–7.45; P = 0.03). A positively significant association was also observed between adherence to western dietary pattern and RA in the fully-adjusted final model (OR = 2.22; 95% CI 1.04–4.72; P = 0.03). Conclusions The study suggests that there is an inverse association between adherence to a healthy dietary pattern and the odds of RA, and a positive significant relationship was found between western dietary pattern and RA. Further studies are required to confirm these findings.

scholarly journals Sarcoidosis and silica dust exposure among men in Sweden: a case–control study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038926
Author(s):  
Pål Graff ◽  
Johanna Larsson ◽  
Ing-Liss Bryngelsson ◽  
Pernilla Wiebert ◽  
Per Vihlborg
Keyword(s):  
Occupational Exposure ◽  
Case Control Study ◽  
Older Men ◽  
Case Control ◽  
Dust Exposure ◽  
Control Analysis ◽  
Silica Exposure ◽  
Silica Dust ◽  
Increased Risk ◽  
Control Study

ObjectiveTo determine whether occupational exposure to silica dust is associated with an increased risk of developing sarcoidosis.DesignCase–control study of all individuals between 20 and 65 years of age diagnosed with sarcoidosis (D86) in Sweden between 2007 and 2016. Controls were matched to cases (2:1) based on age, sex and county at the time of diagnosis. A Job Exposure Matrix was used to estimate the occupational silica exposure of all cases and controls.SettingMedical and occupational data from the National Outpatient Register were used to implement a case–control analysis, while the two controls used for each case were selected from the National Register of the Total Population. Information about occupation and time of employment were collected from the Swedish Occupational Register.ParticipantsAll men and women aged 20–65 years old who were diagnosed sarcoidosis (D86) from 2007 to 2016 were included and assigned two controls.Main outcomesSilica dust exposure correlates with an increased risk of developing sarcoidosis in men.ResultsThe prevalence of silica exposure at work was statistically significantly higher among male cases than controls (OR 1.27, 95% CI 1.13 to 1.43). For men of an age of 35 years or younger the correlation seems to be stronger (OR 1.48, 95% CI 1.1 to 1.87) than in older men (OR 1.21, 95% CI 1.05 to 1.39). For men older than 35 with exposure to silica the prevalence of sarcoidosis increased with the exposure time, with an OR of 1.44 (95% CI 1.04 to 2.00) for exposure of more than 10 years.ConclusionsOccupational exposure to silica dust seems to increase the risk of sarcoidosis among men between 20 and 65 years of age. The risk is higher among exposed men 35 years or younger and older men with longer exposure (>6 years).

scholarly journals O3C.4 Increases the risk of sarcoidosis by silica exposure? A case-control study

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A26.2-A26
Author(s):  
Per Vihlborg ◽  
Pål Graf ◽  
Ing-Liss Bryngelsson
Keyword(s):  
Case Control Study ◽  
International Classification Of Diseases ◽  
Case Control ◽  
Dust Exposure ◽  
Unknown Etiology ◽  
Job Exposure Matrix ◽  
Silica Exposure ◽  
Silica Dust ◽  
Increased Risk ◽  
Control Study

IntroductionSarcoidosis is an inflammatory disease with unknown etiology that involves the formation of granulomas, mainly in the lungs and/or intrathoracic lymph nodes. Hypothesis about the etiology of sarcoidosis are combination of genetic and environmental factors. Previous studies have linked exposure to silica dust with increased risk of sarcoidosis.ObjectA case-control study to investigate the silica exposure among Swedish sarcoidosis cases.MethodsThe data was collected from the National non-primary outpatient care register kept by the Swedish National Board of Health and Welfare. All cases between the age of 20 and 65 with the diagnosis Sarkoidos-D86 according to the International Classification of Diseases, 10th Edition (ICD-10) was included in the study (11 772 cases). The information was matched towards the register for cause of death and the register for emigration.For each case two controls were included matched for age, sex, was resident in the same county, should not be first degree relatives to cases and not have been diagnosed with the investigated disease using the Swedish Central Bureau of Statistics (SCB) multigeneration register. Cases and controls was matched against SCBs occupational registry for work profession. The levels of silica dust exposure were estimated using NOCCA-JEM (Nordic Occupational Cancer study job-exposure matrix) a modified version of the Finnish Information System on Occupational Exposure job-exposure matrix (FINJEM) which is a well-established method of estimating exposure.ResultCases of sarcoidosis have an increased exposure to silica before diagnosis (1.19; 95%  CI 1.1 to 1.30).ConclusionThe increased exposure to silica among sarcoidosis cases suggest that silica can be an environmental factor that contribute to development of sarcoidosis.

scholarly journals Thyroid disorders and breast cancer risk in Asian population: a nationwide population-based case–control study in Taiwan

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020194 ◽  
Author(s):  
Chien-Hsiang Weng ◽  
Yi-Huei Chen ◽  
Ching-Heng Lin ◽  
Xun Luo ◽  
Tseng-Hsi Lin
Keyword(s):  
Breast Cancer ◽  
Index Date ◽  
Case Control Study ◽  
Asian Population ◽  
Population Based ◽  
Case Control ◽  
Thyroid Disorders ◽  
Increased Risk ◽  
History Of ◽  
Control Study

ObjectiveTo evaluate whether hyperthyroidism or hypothyroidism increases the risk of subsequent breast cancer in an Asian population.DesignNationwide population-based case–control study.SettingAll healthcare facilities in Taiwan.ParticipantsA total of 103 466 women (mean age 53.3 years) were enrolled.Methods51 733 adult women with newly diagnosed primary breast cancer without a previous cancer history between 2006 and 2011 were identified and included in our study. 51 733 women with no cancer diagnosis prior to the index date were age matched as controls. Diagnosis of hyperthyroidism or hypothyroidism prior to the diagnosis of breast cancer or the same index date was identified, age, histories of thyroid disease treatment, oestrogen use and radioactive iodine treatment were adjusted.Main outcome measuresTo identify risk differences in developing breast cancer among patients with a medical history of hyperthyroidism or hypothyroidism.ResultsThere was a significantly increased risk of breast cancer in women with hyperthyroidism under the age of 55 years (age <45: OR 1.16, P=0.049; age 45–55: OR 1.15, P=0.019). Patients with hypothyroidism also showed an increased risk of breast cancer (OR 1.19, P=0.029) without statistical significance after stratification by age group (age <45, 45–55, >55 years). Treatment for thyroid disorders did not alter the association in subgroup analyses (P=0.857; 0.262, respectively).ConclusionsAsian women under 55 years of age with history of hyperthyroidism have a significantly increased risk of breast cancer regardless of treatment. Women with history of hypothyroidism may also have an increased risk.

scholarly journals Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study

2015 ◽  
Vol 75 (6) ◽  
pp. 997-1002 ◽  
Author(s):  
Chun Lai Too ◽  
Nor Asiah Muhamad ◽  
Anna Ilar ◽  
Leonid Padyukov ◽  
Lars Alfredsson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Occupational Exposure ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Dust Exposure ◽  
Environment Interaction ◽  
Malaysian Population ◽  
Increased Risk ◽  
Control Study

ObjectivesLung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). We investigated the association between textile dust exposure and the risk of RA in the Malaysian population, with a focus on women who rarely smoke.MethodsData from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis population-based case–control study involving 910 female early RA cases and 910 female age-matched controls were analysed. Self-reported information on ever/never occupationally exposed to textile dust was used to estimate the risk of developing anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. Interaction between textile dust and the human leucocyte antigen DR β-1 (HLA-DRB1) shared epitope (SE) was evaluated by calculating the attributable proportion due to interaction (AP), with 95% CI.ResultsOccupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).ConclusionsThis is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA.

Genetic Variations in Genes Encoding RANK, RANKL, and OPG in Rheumatoid Arthritis: A Case-Control Study

2010 ◽  
Vol 37 (5) ◽  
pp. 900-904 ◽  
Author(s):  
GUNTER ASSMANN ◽  
JOCHEM KOENIG ◽  
MICHAEL PFREUNDSCHUH ◽  
JOERG T. EPPLEN ◽  
JOERN KEKOW ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Structural Damage ◽  
Case Control Study ◽  
Case Control ◽  
Genetic Variations ◽  
Minor Allele ◽  
Taqman Assay ◽  
Systemic Autoimmune Disease ◽  
Increased Risk ◽  
Control Study

Objective.Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints, which may lead to structural damage of the cartilage and bone. The receptor activator of nuclear factor-κB (RANK) and the osteoprotegerin (OPG) cascade system have been reported to be essential in osteoclastogenesis. Genetic variations in the genes coding for RANK, RANK ligand (RANKL), and OPG are thought to play roles in the susceptibility to RA.Methods.In our case-control study, genomic DNA was obtained from 534 patients with RA who fulfilled the American College of Rheumatology 1987 criteria and 516 healthy control blood donors (HC). We studied 7 single-nucleotide polymorphisms (SNP) in the genes of RANK (2 SNP: rs1805034, rs35211496), OPG (2 SNP: rs3102735, rs2073618), and RANKL (3 SNP: rs9533156, rs2277438, rs1054016) using TaqMan assay-guided polymerase chain reaction. Genotype and allelic frequencies comparing RA patients with HC were analyzed by chi-square test for 2 × 3 and 2 × 2 tables, respectively.Results.Genotype distributions of the SNP rs35211496 in the RANK gene as well as the SNP rs2277438 in the RANKL gene differed significantly between patients with RA and HC. The frequency of the minor allele of rs9533156 of RANKL was significantly higher in patients with RA than in HC (OR 0.84, 95% CI 0.71–0.99, p = 0.047). Multivariate analysis adjusted to sex and investigating SNP demonstrated a significantly elevated risk for RA associated with the major allele in the RANK SNP rs35211496 (p = 0.0231) and with the minor allele in the RANKL SNP rs2277438 (p = 0.0092). No significantly increased risk was detected in the other SNP.Conclusion.The minor allele of the RANK SNP rs35211496 may be protective against RA, while the minor alleles of the RANKL SNP rs2277438 may increase susceptibility to RA.

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