DETERMINATION OF 226RA IN URINE USING TRIPLE QUADRUPOLE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY

2020 ◽  
Vol 191 (4) ◽  
pp. 391-399
Author(s):  
Ge Xiao ◽  
Yongzhong Liu ◽  
Robert L Jones
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Clinical Decision ◽  
Standard Reference Materials ◽  
Triple Quadrupole ◽  
Inductively Coupled ◽  
Target Values ◽  
Plasma Mass Spectrometry

Abstract Measuring 226Ra in urine at low levels is critical for both biomonitoring and radiological emergency response. Here we report a new analytical method to quantify 226Ra, as developed and validated by a simple dilute-and-shoot procedure, followed by Inductively Coupled Plasma-triple quadrupole-mass spectrometry detection using ‘No Gas MS-MS’ mode. The method provides rapid and accurate results for 226Ra with a limit of detection (LOD) down to 0.007 ng/l (0.26 Bq/l). This LOD is well below the recommended action levels for 226Ra detection in children and pregnant women (C/P) set by the Clinical Decision Guide (NCRP Report #161). Results for 226Ra obtained by this method are within ±7.0% of the target values of standard reference materials spiked in the urine.

scholarly journals Determination of phosphorus and sulfur in uranium ore concentrates by triple quadrupole inductively coupled plasma mass spectrometry

Talanta ◽  
2021 ◽  
Vol 221 ◽  
pp. 121573
Author(s):  
Nathaniel D. Fletcher ◽  
Benjamin T. Manard ◽  
Debra A. Bostick ◽  
William D. Bostick ◽  
Shalina C. Metzger ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Triple Quadrupole ◽  
Uranium Ore ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

A standard addition method to quantify serum lithium by inductively coupled plasma mass spectrometry

2021 ◽  
pp. 000456322110547
Author(s):  
Xiaoyu Fan ◽  
Qing Li ◽  
Ping Lin ◽  
Zhonggan Jin ◽  
Meizi Chen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Standard Reference Materials ◽  
Addition Method ◽  
Serum Samples ◽  
Inductively Coupled ◽  
Target Values ◽  
Plasma Mass Spectrometry

Background Therapeutic monitoring of lithium (Li) is important because of its narrow therapeutic range and therapeutic index. Here, the authors present the evaluation of an accurate method for the determination of lithium in serum. Method Serum samples were diluted with 0.3% ultrapure nitric acid and were spiked with an internal standard germanium (Ge). The Li/Ge ratio was detected in He mode; we utilized standard addition method to quantify lithium in human serum. The new inductively coupled plasma mass spectrometry (ICP-MS) assay was characterized for linearity, specificity, imprecision, trueness, accuracy, and comparison. Results The correlation coefficients (r) of linearity were all > 0.9999. The specificity proved to be good. The total coefficients of variation (CV) were 1.11% and 0.49% for the two serum samples. The mean bias from target values of standard reference materials (SRM 956d) was −0.71% for Level I, −017% for Level II, and 2.20 for Level III. External Quality Assessment Scheme for Reference Laboratories in Laboratory Medicine (RELA) gave satisfied results for the new method. Comparison with the ion-selective electrode routine method got reasonable results. Conclusion This high accuracy method is an attractive alternative for lithium measurement and can be used as a candidate reference method to improve quality of serum lithium in China.

scholarly journals Determination of Metals in Composite Diet Samples by Inductively Coupled Plasma-Mass Spectrometry

2003 ◽  
Vol 86 (2) ◽  
pp. 439-448 ◽  
Author(s):  
Lisa Jo Melnyk ◽  
Jeffrey N Morgan ◽  
Reshan Fernando ◽  
Edo D Pellizzari ◽  
Olujide Akinbo
Keyword(s):  
Mass Spectrometry ◽  
Atmospheric Pressure ◽  
Inductively Coupled Plasma ◽  
Microwave Digestion ◽  
Standard Reference Materials ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Relative Standard ◽  
Plasma Mass Spectrometry

Abstract A study was conducted to evaluate the applicability of inductively coupled plasma-mass spectrometry (ICP-MS) techniques for determination of metals in composite diets. Aluminum, cadmium, chromium, copper, lead, manganese, nickel, vanadium, and zinc were determined by this method. Atmospheric pressure microwave digestion was used to solubilize analytes in homogenized composite diet samples, and this procedure was followed by ICP-MS analysis. Recovery of certified elements from standard reference materials ranged from 92 to 119% with relative standard deviations (RSDs) of 0.4–1.9%. Recovery of elements from fortified composite diet samples ranged from 75 to 129% with RSDs of 0–11.3%. Limits of detection ranged from 1 to 1700 ng/g; high values were due to significant amounts of certain elements naturally present in composite diets. Results of this study demonstrate that low-resolution quadrupole-based ICP-MS provides precise and accurate measurements of the elements tested in composite diet samples.

Determination of Heavy Metals in Rhizomes of Alpinia galanga by Inductively Coupled Plasma Mass Spectrometry

2011 ◽  
Vol 486 ◽  
pp. 143-146 ◽  
Author(s):  
Chutima Limmatvapirat ◽  
Thawatchai Phaechamud ◽  
Juree Charoenteeraboon
Keyword(s):  
Mass Spectrometry ◽  
Heavy Metals ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Acid Digestion ◽  
Alpinia Galanga ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Galangal (Alpinia galanga(Linn.) Swartz.) is a popular spice in Thailand. Heavy metals, deriving from environmental pollution, might be contaminated in galangal rhizomes. Inductively coupled plasma mass spectrometry (ICP-MS) was a new and fast technique for ultratrace elemental analysis. The aim of this study was to validate a method for the determination of aluminium (Al), arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in galangal rhizomes according to the European standards (EU) using nitric acid digestion followed by ICP-MS. The parameters evaluated in the validation were recovery, repeatability and within-laboratory reproducibility, limit of detection (LOD), and limit of quantification (LOQ). This method was used to analyze the concentrations of 11 heavy metals in 15 samples of galangal rhizomes collected in Nakhon Pathom province. The metal concentrations varied considerably in the different sample sources. The concentration of heavy metals in the galangal samples arranged in increasing order was Hg < Cd < As < Cr < Pb < Ni < Cu < Zn < Fe < Mn < Al. An acid digestion and ICP-MS method was applicable to determination of 11 heavy metals in galangal rhizomes, based on the recovery analysis, cost, and time taken

Determination of Ultratrace Levels of Lead in Infant Formula by Isotope Dilution Inductively Coupled Plasma Mass Spectrometry

1993 ◽  
Vol 76 (6) ◽  
pp. 1378-1384 ◽  
Author(s):  
Joseph J Thompson
Keyword(s):  
Mass Spectrometry ◽  
Infant Formula ◽  
Reference Materials ◽  
Isotope Dilution ◽  
Inductively Coupled Plasma ◽  
Standard Reference Materials ◽  
Inductively Coupled ◽  
Relative Standard ◽  
Plasma Mass Spectrometry

Abstract A simple method was developed for the accurate and precise determination of low- and sub-ppb (ng/g) concentrations of lead in infant formula by isotope dilution inductively coupled plasma mass spectrometry using ultrasonic nebulization. After addition of a known amount of 207Pb, samples were microwave digested and the ratio 207Pb/208Pb was measured in the digests. Agreement with certified values for lead in milk powder standard reference materials was good, and isotope dilution analysis using 206Pb yielded identical results for the standard reference materials. Lead concentrations determined for several infant nutritional products were verified by an independent method. Typically, relative standard deviations of &lt;4% were obtained with this method for lead concentrations above 2 ppb. The recovery of 2 ng of lead from an aqueous standard carried through the microwave digestion was 104 ± 4%. Infant formula (containing 0.6 ppb lead) to which 0.4 ng of natural-abundance lead had been added, to simulate a formula containing 0.9 ppb lead, was analyzed by isotope dilution, and the result was 96 ± 18% of the theoretical value. Thus, differences of 0.3 ppb lead could be clearly distinguished, and the detection limit was estimated to be 0.1 ng lead per gram of infant formula. The keys to accuracy for this method are minimizing contamination and accurately determining the concentration of lead in the isotopically enriched standard.

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