Aberrant reward dynamics in trait anticipatory anhedonia

Abstract As a cardinal feature of several psychiatric disorders, anhedonia includes a consummatory component (deficits in hedonic response to rewards) and an anticipatory component (a reduced motivation to pursue them). Although being conceptualized as impairments of reward system, the neural characterization of reward processing in anhedonia is hampered by the enormous heterogeneity in the reward phase (‘wanting’ vs ‘liking’) and comorbidity (inherent to disease states). The current event-related potential (ERP) study examined the reward dynamics of anticipatory anhedonia in a non-clinical sample. Anticipatory and consummatory ERP components were assessed with a monetary incentive delay task in a high anticipatory anhedonia (HAA) group and a low anticipatory anhedonia (LAA) group. HAA vs LAA group showed a diminished reward-related speeding during behavioral performance and reported overall reduced positive affect during anticipation and receipt of outcomes. Importantly, neural dynamics underlying reward processing were negatively associated with anticipatory anhedonia across the anticipatory phase indexed by the contingent negative variation and the consummatory phase indexed by the feedback P3. Our results suggest that anticipatory anhedonia in non-clinical individuals is linked to a poor modulation during both anticipatory and consummatory phases of reward processing.

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Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms

Psychological Medicine ◽

10.1017/s0033291720003967 ◽

2020 ◽

pp. 1-15

Author(s):

Dandan Zhang ◽

Junshi Shen ◽

Rong Bi ◽

Yueyao Zhang ◽

Fang Zhou ◽

...

Keyword(s):

Depressive Symptoms ◽

Depressive Symptomatology ◽

Reward Processing ◽

Event Related Potential ◽

Control Group ◽

Social Reward ◽

Small Magnitude ◽

Hit Rate ◽

Reward Anticipation ◽

Monetary Incentive Delay

Abstract Background Reward dysfunction is a major dimension of depressive symptomatology, but it remains obscure if that dysfunction varies across different reward types. In this study, we focus on the abnormalities in anticipatory/consummatory processing of monetary and social reward associated with depressive symptoms. Methods Forty participants with depressive symptoms and forty normal controls completed the monetary incentive delay (MID) and social incentive delay (SID) tasks with event-related potential (ERP) recording. Results In the SID but not the MID task, both the behavioral hit rate and the ERP component contingent negative variation (CNV; indicating reward anticipation) were sensitive to the interaction between the grouping factor and reward magnitude; that is, the depressive group showed a lower hit rate and a smaller CNV to large-magnitude (but not small-magnitude) social reward cues compared to the control group. Further, these two indexes were correlated with each other. Meanwhile, the ERP components feedback-related negativity and P3 (indicating reward consumption) were sensitive to the main effect of depression across the MID and SID tasks, though this effect was more prominent in the SID task. Conclusions Overall, we suggest that depressive symptoms are associated with deficits in both the reward anticipation and reward consumption stages, particularly for social rewards. These findings have a potential to characterize the profile of functional impairment that comprises and maintains depression.

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Supplemental Material for Reward Processing in Certain Versus Uncertain Contexts in Schizophrenia: An Event-Related Potential (ERP) Study

Journal of Abnormal Psychology ◽

10.1037/abn0000469.supp ◽

2019 ◽

Keyword(s):

Reward Processing ◽

Event Related Potential

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Reward Processing in Late Life Depression: Insights From the Monetary Incentive Delay Task

Biological Psychiatry ◽

10.1016/j.biopsych.2021.02.757 ◽

2021 ◽

Vol 89 (9) ◽

pp. S303-S304

Author(s):

Jack Kaufman ◽

Joseph Kim ◽

Anna Bradford ◽

Jacob Germain ◽

Victor Patron ◽

...

Keyword(s):

Late Life ◽

Monetary Incentive ◽

Reward Processing ◽

Late Life Depression ◽

Delay Task ◽

Monetary Incentive Delay Task ◽

Monetary Incentive Delay

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P.334 An event-related potential study of reward processing in subjects with schizophrenia and healthy controls

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2019.12.116 ◽

2020 ◽

Vol 31 ◽

pp. S72-S73

Author(s):

Ö. Akgül ◽

E. Fide ◽

F. Özel ◽

K. Alptekin ◽

G. Yener ◽

...

Keyword(s):

Reward Processing ◽

Event Related Potential ◽

Healthy Controls ◽

Potential Study

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Investigating Influences of Medial Olivocochlear Efferent System on Central Auditory Processing and Listening in Noise: A Behavioral and Event-Related Potential Study

Brain Sciences ◽

10.3390/brainsci10070428 ◽

2020 ◽

Vol 10 (7) ◽

pp. 428

Author(s):

Aparna Rao ◽

Tess K. Koerner ◽

Brandon Madsen ◽

Yang Zhang

Keyword(s):

Word Recognition ◽

Otoacoustic Emission ◽

Event Related Potential ◽

Behavioral Performance ◽

Contralateral Stimulation ◽

Related Potentials ◽

Noise Test ◽

Medial Olivocochlear ◽

Listening In Noise ◽

Physiological Tests

This electrophysiological study investigated the role of the medial olivocochlear (MOC) efferents in listening in noise. Both ears of eleven normal-hearing adult participants were tested. The physiological tests consisted of transient-evoked otoacoustic emission (TEOAE) inhibition and the measurement of cortical event-related potentials (ERPs). The mismatch negativity (MMN) and P300 responses were obtained in passive and active listening tasks, respectively. Behavioral responses for the word recognition in noise test were also analyzed. Consistent with previous findings, the TEOAE data showed significant inhibition in the presence of contralateral acoustic stimulation. However, performance in the word recognition in noise test was comparable for the two conditions (i.e., without contralateral stimulation and with contralateral stimulation). Peak latencies and peak amplitudes of MMN and P300 did not show changes with contralateral stimulation. Behavioral performance was also maintained in the P300 task. Together, the results show that the peripheral auditory efferent effects captured via otoacoustic emission (OAE) inhibition might not necessarily be reflected in measures of central cortical processing and behavioral performance. As the MOC effects may not play a role in all listening situations in adults, the functional significance of the cochlear effects of the medial olivocochlear efferents and the optimal conditions conducive to corresponding effects in behavioral and cortical responses remain to be elucidated.

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Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone

Psychological Medicine ◽

10.1017/s0033291718003306 ◽

2019 ◽

Vol 49 (08) ◽

pp. 1365-1377 ◽

Cited By ~ 4

Author(s):

Selina A. Wolke ◽

Mitul A. Mehta ◽

Owen O'Daly ◽

Fernando Zelaya ◽

Nada Zahreddine ◽

...

Keyword(s):

Depressive Symptoms ◽

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Reward Processing ◽

Anterior Cingulate ◽

Depression Severity ◽

Placebo Condition ◽

Double Blind ◽

Monetary Incentive Delay ◽

Reward Functions

AbstractBackgroundAberrations in reward and penalty processing are implicated in depression and putatively reflect altered dopamine signalling. This study exploits the advantages of a placebo-controlled design to examine how a novel D2antagonist with adjunctive antidepressant properties modifies activity in the brain's reward network in depression.MethodsWe recruited 43 medication-naïve subjects across the range of depression severity (Beck's Depression Inventory-II score range: 0–43), including healthy volunteers, as well as people meeting full-criteria for major depressive disorder. In a double-blind placebo-controlled cross-over design, all subjects received either placebo or lurasidone (20 mg) across two visits separated by 1 week. Functional magnetic resonance imaging with the Monetary Incentive Delay (MID) task assessed reward functions via neural responses during anticipation and receipt of gains and losses. Arterial spin labelling measured cerebral blood flow (CBF) at rest.ResultsLurasidone altered fronto-striatal activity during anticipation and outcome phases of the MID task. A significant three-way Medication-by-Depression severity-by-Outcome interaction emerged in the anterior cingulate cortex (ACC) after correction for multiple comparisons. Follow-up analyses revealed significantly higher ACC activation to losses in high-v.low depression participants in the placebo condition, with a normalisation by lurasidone. This effect could not be accounted for by shifts in resting CBF.ConclusionsLurasidone acutely normalises reward processing signals in individuals with depressive symptoms. Lurasidone's antidepressant effects may arise from reducing responses to penalty outcomes in individuals with depressive symptoms.

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Network-based characterization of disease–disease relationships in terms of drugs and therapeutic targets

Bioinformatics ◽

10.1093/bioinformatics/btaa439 ◽

2020 ◽

Vol 36 (Supplement_1) ◽

pp. i516-i524

Author(s):

Midori Iida ◽

Michio Iwata ◽

Yoshihiro Yamanishi

Keyword(s):

Large Scale ◽

Expression Patterns ◽

Therapeutic Targets ◽

Molecular Networks ◽

Supplementary Information ◽

New Associations ◽

Disease States ◽

Molecular Features ◽

Novel Approach

Abstract Motivation Disease states are distinguished from each other in terms of differing clinical phenotypes, but characteristic molecular features are often common to various diseases. Similarities between diseases can be explained by characteristic gene expression patterns. However, most disease–disease relationships remain uncharacterized. Results In this study, we proposed a novel approach for network-based characterization of disease–disease relationships in terms of drugs and therapeutic targets. We performed large-scale analyses of omics data and molecular interaction networks for 79 diseases, including adrenoleukodystrophy, leukaemia, Alzheimer's disease, asthma, atopic dermatitis, breast cancer, cystic fibrosis and inflammatory bowel disease. We quantified disease–disease similarities based on proximities of abnormally expressed genes in various molecular networks, and showed that similarities between diseases could be explained by characteristic molecular network topologies. Furthermore, we developed a kernel matrix regression algorithm to predict the commonalities of drugs and therapeutic targets among diseases. Our comprehensive prediction strategy indicated many new associations among phenotypically diverse diseases. Supplementary information Supplementary data are available at Bioinformatics online.

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Galvanic vestibular stimulation modulates the electrophysiological response during face processing

Visual Neuroscience ◽

10.1017/s0952523812000235 ◽

2012 ◽

Vol 29 (4-5) ◽

pp. 255-262 ◽

Cited By ~ 10

Author(s):

DAVID WILKINSON ◽

HEATHER J. FERGUSON ◽

ALAN WORLEY

Keyword(s):

Face Processing ◽

Power Spectra ◽

Vestibular Stimulation ◽

Therapeutic Benefit ◽

Galvanic Vestibular Stimulation ◽

Event Related Potential ◽

Electrophysiological Response ◽

Disease States ◽

Vestibular Information ◽

Theta Frequency

AbstractAlthough galvanic vestibular stimulation (GVS) is known to affect the speed and accuracy of visual judgments, the underlying electrophysiological response has not been explored. In the present study, we therefore investigated the effect of GVS on the N170 event-related potential, a marker commonly associated with early visual structural encoding. To elicit the waveform, participants distinguished famous from nonfamous faces that were presented in either upright or inverted orientation. Relative to a sham, stimulation increased the amplitude of the N170 and also elevated power spectra within the delta and theta frequency bands, components that have likewise been associated with face processing. This study constitutes the first attempt to model the effects of GVS on the electrophysiological response and, more specifically, indicates that unisensory visual processes linked to object construction are influenced by vestibular information. Given that reductions in the magnitude of both the N170 event-related potential and delta/theta activity accompany certain disease states, GVS may provide hitherto unreported therapeutic benefit.

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