Differentiating the abnormalities of social and monetary reward processing associated with depressive symptoms

2020 ◽  
pp. 1-15
Author(s):  
Dandan Zhang ◽  
Junshi Shen ◽  
Rong Bi ◽  
Yueyao Zhang ◽  
Fang Zhou ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptomatology ◽  
Reward Processing ◽  
Event Related Potential ◽  
Control Group ◽  
Social Reward ◽  
Small Magnitude ◽  
Hit Rate ◽  
Reward Anticipation ◽  
Monetary Incentive Delay

Abstract Background Reward dysfunction is a major dimension of depressive symptomatology, but it remains obscure if that dysfunction varies across different reward types. In this study, we focus on the abnormalities in anticipatory/consummatory processing of monetary and social reward associated with depressive symptoms. Methods Forty participants with depressive symptoms and forty normal controls completed the monetary incentive delay (MID) and social incentive delay (SID) tasks with event-related potential (ERP) recording. Results In the SID but not the MID task, both the behavioral hit rate and the ERP component contingent negative variation (CNV; indicating reward anticipation) were sensitive to the interaction between the grouping factor and reward magnitude; that is, the depressive group showed a lower hit rate and a smaller CNV to large-magnitude (but not small-magnitude) social reward cues compared to the control group. Further, these two indexes were correlated with each other. Meanwhile, the ERP components feedback-related negativity and P3 (indicating reward consumption) were sensitive to the main effect of depression across the MID and SID tasks, though this effect was more prominent in the SID task. Conclusions Overall, we suggest that depressive symptoms are associated with deficits in both the reward anticipation and reward consumption stages, particularly for social rewards. These findings have a potential to characterize the profile of functional impairment that comprises and maintains depression.

scholarly journals Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone

2019 ◽  
Vol 49 (08) ◽  
pp. 1365-1377 ◽  
Author(s):  
Selina A. Wolke ◽  
Mitul A. Mehta ◽  
Owen O'Daly ◽  
Fernando Zelaya ◽  
Nada Zahreddine ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Reward Processing ◽  
Anterior Cingulate ◽  
Depression Severity ◽  
Placebo Condition ◽  
Double Blind ◽  
Monetary Incentive Delay ◽  
Reward Functions

AbstractBackgroundAberrations in reward and penalty processing are implicated in depression and putatively reflect altered dopamine signalling. This study exploits the advantages of a placebo-controlled design to examine how a novel D2antagonist with adjunctive antidepressant properties modifies activity in the brain's reward network in depression.MethodsWe recruited 43 medication-naïve subjects across the range of depression severity (Beck's Depression Inventory-II score range: 0–43), including healthy volunteers, as well as people meeting full-criteria for major depressive disorder. In a double-blind placebo-controlled cross-over design, all subjects received either placebo or lurasidone (20 mg) across two visits separated by 1 week. Functional magnetic resonance imaging with the Monetary Incentive Delay (MID) task assessed reward functions via neural responses during anticipation and receipt of gains and losses. Arterial spin labelling measured cerebral blood flow (CBF) at rest.ResultsLurasidone altered fronto-striatal activity during anticipation and outcome phases of the MID task. A significant three-way Medication-by-Depression severity-by-Outcome interaction emerged in the anterior cingulate cortex (ACC) after correction for multiple comparisons. Follow-up analyses revealed significantly higher ACC activation to losses in high-v.low depression participants in the placebo condition, with a normalisation by lurasidone. This effect could not be accounted for by shifts in resting CBF.ConclusionsLurasidone acutely normalises reward processing signals in individuals with depressive symptoms. Lurasidone's antidepressant effects may arise from reducing responses to penalty outcomes in individuals with depressive symptoms.

scholarly journals Aberrant reward dynamics in trait anticipatory anhedonia

2019 ◽  
Vol 14 (8) ◽  
pp. 899-909
Author(s):  
Shiyu Zhou ◽  
Lu Nie ◽  
Zhao Wang ◽  
Mengyao Wang ◽  
Ya Zheng
Keyword(s):  
Clinical Sample ◽  
Reward Processing ◽  
Event Related Potential ◽  
Behavioral Performance ◽  
Current Event ◽  
Disease States ◽  
Monetary Incentive Delay ◽  
Anticipatory Anhedonia ◽  
Cardinal Feature

Abstract As a cardinal feature of several psychiatric disorders, anhedonia includes a consummatory component (deficits in hedonic response to rewards) and an anticipatory component (a reduced motivation to pursue them). Although being conceptualized as impairments of reward system, the neural characterization of reward processing in anhedonia is hampered by the enormous heterogeneity in the reward phase (‘wanting’ vs ‘liking’) and comorbidity (inherent to disease states). The current event-related potential (ERP) study examined the reward dynamics of anticipatory anhedonia in a non-clinical sample. Anticipatory and consummatory ERP components were assessed with a monetary incentive delay task in a high anticipatory anhedonia (HAA) group and a low anticipatory anhedonia (LAA) group. HAA vs LAA group showed a diminished reward-related speeding during behavioral performance and reported overall reduced positive affect during anticipation and receipt of outcomes. Importantly, neural dynamics underlying reward processing were negatively associated with anticipatory anhedonia across the anticipatory phase indexed by the contingent negative variation and the consummatory phase indexed by the feedback P3. Our results suggest that anticipatory anhedonia in non-clinical individuals is linked to a poor modulation during both anticipatory and consummatory phases of reward processing.

scholarly journals The Effects of Self-Management Interventions on Depressive Symptoms In Adults With Chronic Physical Disease(S) Experiencing Depressive Symptomatology: A Systematic Review And Meta-Analysis

2021 ◽  
Author(s):  
Lydia Ould Brahim ◽  
Sylvie Lambert ◽  
Nancy Feeley ◽  
Chelsea Coumoundouros ◽  
Jamie Schaffler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Depressive Symptoms ◽  
Chronic Disease ◽  
Glycemic Control ◽  
Depressive Symptomatology ◽  
Meta Analysis ◽  
Self Management ◽  
Control Group ◽  
Physical Disease ◽  
Management Interventions

Abstract Background: Chronic diseases are the leading cause of death worldwide. It is estimated that 20% of adults with chronic physical diseases experience concomitant depression, increasing their risk of morbidity and mortality. Low intensity psychosocial interventions, such as self-management (SM), are part of recommended treatment; however, no systematic review has evaluated the effects of depression SM interventions for this population. Objectives: The primary objective was to examine the effect of SM interventions on reducing depressive symptomatology in adults with chronic disease(s) and co-occurring depressive symptoms. Secondary objectives were to evaluate the effect of these interventions on improving other psychosocial and physiological outcomes (e.g., anxiety, glycemic control) and to assess potential differential effect based on key participant and intervention characteristics (e.g., chronic disease, provider). Methods: Studies comparing depression SM interventions to a control group were identified through a) systematic searches of databases to June 2018 [MEDLINE (1946 -), EMBASE (1996 -), PsycINFO (1967 -), CINAHL (1984 -)] and b) secondary ‘snowball’ search strategies. The methodological quality of included studies was critically reviewed. Screening of all titles, abstracts, and full texts for eligibility was assessed independently by two authors. Data were extracted by one author and verified by a second. Results: Fifteen studies were retained: 12 for meta-analysis and three for descriptive review. In total, these trials included 2064 participants and most commonly evaluated interventions for people with cancer (n = 7) or diabetes (n = 4). From baseline to < 6 months (T1), the pooled mean effect size was -0.47 [95% CI -0.73, -0.21] as compared to control groups for the primary outcome of depression and -0.53 [95% CI -0.91, -0.15] at ≥ 6-months (T2). Results were also significant for anxiety (T1 and T2) and glycemic control (T2). SM skills of decision-making and taking action were significant moderators of depression at T1. Conclusion: SM interventions show promise in improving depression and anxiety in those with concomitant chronic physical disease. The findings may contribute to the development of future SM interventions and delivering evidence-based care to this population. Further high-quality RCTs are needed to identify sources of heterogeneity and investigate key intervention components. Prospero registration: CRD42019132215

Efficacy of an online intervention for treatment of depressive disorders: a three-arm randomized controlled trial comparing guided and unguided self-help with waitlist control (Preprint)

2021 ◽  
Author(s):  
Krämer Rico
Keyword(s):  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Depressive Symptomatology ◽  
Controlled Trial ◽  
Intervention Group ◽  
Online Intervention ◽  
Self Report ◽  
Secondary Outcome ◽  
Control Group

BACKGROUND Digital health applications are efficacious treatment options for mild-to-moderate depressive disorders. However, the extent to which psychological guidance increases the efficacy of these applications is controversial. OBJECTIVE We evaluated the efficacy of the online intervention “Selfapy” for unipolar depression. We also investigated differences between a psychotherapist-guided vs. unguided version compared with those from a control group. METHODS A cohort of 401 participants with mild-to-severe depressive disorders were assigned randomly to either participate in a guided version of Selfapy (involving weekly telephone calls of 25-min duration), an unguided version of Selfapy, or to the waiting list (control group). Selfapy is a cognitive behavioral therapy-based intervention for depressive disorders of duration 12 weeks. Symptom assessment was undertaken at T1 (before study entrance), T2 (after 6 weeks), T3 (post-treatment, after 12 weeks), and T4 (follow-up, after 6 months). The main outcome was reduction in depressive symptoms in the Beck Depression Inventory (BDI-II) from T1 to T3. Secondary-outcome parameters were the Quick Inventory of Depressive Symptomatology – Self Report (QIDS-SR 16) and Beck Anxiety Inventory (BAI). RESULTS A total of 297 out of 401 participants (74.06%) completed the post-measurement at T3. In the primary analysis, both intervention groups showed a significantly higher reduction in depressive symptoms (BDI-II) from T1 to T3 compared with that in the control group, with high within-effect sizes (guided: d = 1.46; unguided d = 1.36). No significant differences were found for guided vs. unguided treatment groups. The response rate (BDI-II) for intention-to-treat data in the guided version was 46.4%, 40.0% for the unguided version, and 2.0% in the control group. After 6 months (T4), treatment effects could been maintained for both intervention groups (BDI-II) without differences between either intervention group. CONCLUSIONS Conclusions: Selfapy can help to reduce depressive symptoms in guided or unguided version. Follow-up data suggest that these effects could be maintained. The guided version was not superior to the unguided version. CLINICALTRIAL Trial Registration: Current Controlled Trial DRKS00017191 Date of registration: 14 May 2019 INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1186/s13063-021-05218-4

Negative Self-Beliefs in Relation to Eating Disorder and Depressive Symptoms: Different Themes Are Characteristic of the Two Sets of Symptoms in Those With Eating Disorders and/or Depression

2009 ◽  
Vol 23 (2) ◽  
pp. 147-159 ◽  
Author(s):  
Myra J. Cooper ◽  
Phil Cowen
Keyword(s):  
Eating Disorders ◽  
Eating Disorder ◽  
Depressive Symptoms ◽  
Depressive Symptomatology ◽  
Self Report ◽  
Control Group ◽  
Core Beliefs ◽  
Regression Analyses ◽  
Eating Disordered ◽  
Eating Disorder Symptoms

This study aimed to identify differences in the personal themes in negative self or core beliefs that might be characteristic of high levels of eating disorder symptoms when compared to high levels of depressive symptoms in those with an eating disorder and/or depression. Differences between putative diagnostic subgroups were also examined. One hundred and ninety-three participants completed self-report measures of negative self-beliefs, eating, and depressive symptoms. Putative diagnostic subgroups were also identified, including an eating disorder group that also had high levels of depressive symptomatology and in most cases a diagnosis of depression. Six themes descriptive of the self corresponding to 6 robust factors were identified and provisionally labeled isolated, repelled by self, self-dislike, lacking in warmth, childlike, and highly organized. Multiple regression analyses indicated that, in the whole sample, eating disorder symptoms were uniquely predicted by subscales reflective of repelled by self and lacking in warmth, though depressive symptoms were uniquely predicted by subscales measuring isolation and self-dislike. Between-group analyses indicated that high scores on isolation, self-dislike, and lacking in warmth were typical of both eating-disordered and depressed-only diagnostic groups when compared to the control group, though only the eating-disordered group (also high in depressive symptoms and “diagnosis” of depression) also had high scores on repelled by self. The findings indicate that eating disorder and depressive symptoms are associated with some potentially important differences in self-beliefs. Putative diagnostic subgroups may also differ in these beliefs. The findings further indicate that psychometrically sound themes exist in the core or negative self-beliefs associated with eating disorder and depressive symptoms. Implications of the findings for cognitive therapy with eating disorders and depression are briefly considered, and the limitations and implications of the diagnostic subgroups identified here are discussed.

scholarly journals Diminishing Effects After Recurrent Use of Self-Guided Internet-Based Interventions in Depression: Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Lara Bücker ◽  
Patricia Schnakenberg ◽  
Eirini Karyotaki ◽  
Steffen Moritz ◽  
Stefan Westermann
Keyword(s):  
Depressive Symptoms ◽  
Depressive Symptomatology ◽  
Psychiatric Symptoms ◽  
Controlled Trial ◽  
Control Group ◽  
Intention To Treat ◽  
Treatment Of Depression ◽  
Post Assessment ◽  
Internet Based Intervention ◽  
Intervention Condition

BACKGROUND Self-guided internet-based interventions have several advantages over guided interventions and are generally effective in treating psychiatric symptoms. OBJECTIVE We aimed to investigate whether the use of a new self-guided internet-based intervention (MOOD) would lead to a significant reduction in depressive symptoms compared with a care-as-usual (CAU) control group in a sample of individuals with depressive symptoms, most of whom had already used a different self-guided internet-based intervention in a previous trial. METHODS A total of 125 individuals were randomized to the intervention condition (MOOD) and received access to the intervention for a period of six weeks or a CAU group. After six weeks, all participants were invited to take part in the post assessment. The Beck Depression Inventory-II served as the primary outcome. RESULTS Both intention-to-treat as well as per-protocol analyses indicated that the depressive symptomatology decreased in both conditions but showed no advantage for those who had used MOOD. Subsequent moderation analyses suggested that those individuals who had less experience with psychotherapy benefitted to a greater extent compared with those with more experience. CONCLUSIONS Self-guided internet-based interventions are deemed a suitable first-step approach to the treatment of depression. However, our results indicate that they are more efficacious in those with less psychotherapy experience. CLINICALTRIAL ClinicalTrials.gov NCT03795480; http://clinicaltrials.gov/ct2/show/NCT03795480

The stability of the feedback negativity and its relationship with depression during childhood and adolescence

2015 ◽  
Vol 27 (4pt1) ◽  
pp. 1285-1294 ◽  
Author(s):  
Jennifer N. Bress ◽  
Alexandria Meyer ◽  
Greg Hajcak Proudfit
Keyword(s):  
Depressive Symptoms ◽  
Neural Activity ◽  
Depressive Symptomatology ◽  
Event Related Potential ◽  
Monetary Reward ◽  
Childhood And Adolescence ◽  
Feedback Negativity ◽  
The Stability ◽  
The Relationship ◽  
Monetary Gain

AbstractFeedback negativity (FN) is an event-related potential elicited by monetary reward and loss; it is thought to relate to reward-related neural activity and has been linked to depression in children and adults. In the current study, we examined the stability of FN, and its relationship with depression in adolescents, over 2 years in 45 8- to 13-year-old children. From Time 1 to Time 2, FN in response to monetary loss and in response to monetary gain showed moderate to strong reliability (rs = .64 and .67, respectively); these relationships remained significant even when accounting for related variables. FN also demonstrated high within-session reliability. Moreover, the relationship between a blunted FN and greater depression observed at Time 1 was reproduced at Time 2, and the magnitude of FN at Time 1 predicted depressive symptomatology at Time 2. These findings are consistent with the hypothesis that FN and its relationship with depression remain consistent over the course of development, and that FN may prospectively predict later depressive symptomatology. The current results suggest that FN may be suitable as a biomarker of depressive symptoms during adolescence.

scholarly journals No effect of a dopaminergic modulation fMRI task by amisulpride and L-DOPA on reward anticipation in healthy volunteers

2020 ◽  
Author(s):  
Oliver Grimm ◽  
Magdalena Nägele ◽  
Lea Küpper-Tetzel ◽  
Moritz de Greck ◽  
Michael Plichta ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Region Of Interest ◽  
Reward System ◽  
Blood Oxygen Level Dependent ◽  
Brain Regions ◽  
Reward Processing ◽  
Activity Level ◽  
Placebo Condition ◽  
Reward Anticipation ◽  
Monetary Incentive Delay

Abstract Rationale Dysregulation of dopaminergic neurotransmission, specifically altered reward processing assessed via the reward anticipation in the MID task, plays a central role in the etiopathogenesis of neuropsychiatric disorders. Objectives We hypothesized to find a difference in the activity level of the reward system (measured by the proxy reward anticipation) under drug administration versus placebo, in that amisulpride reduces, and L-DOPA enhances, its activity. Methods We studied the influence of dopamine agonist L-DOPA and the antagonist amisulpride on the reward system using functional magnetic resonance imaging (fMRI) during a monetary incentive delay (MID) task in n = 45 healthy volunteers in a randomized, blinded, cross-over study. Results The MID paradigm elicits strong activation in reward-dependent structures (such as ventral striatum, putamen, caudate, anterior insula) during reward anticipation. The placebo effect demonstrated the expected significant blood oxygen level–dependent activity in reward-dependent brain regions. Neither amisulpride nor L-DOPA led to significant changes in comparison with the placebo condition. This was true for whole-brain analysis as well as analysis of a pre-defined nucleus accumbens region-of-interest mask. Conclusion The present results cast doubt on the sensitivity of reward anticipation contrast in the MID task for assessing dopamine-specific changes in healthy volunteers by pharmaco-fMRI. While our task was not well-suited for detailed analysis of the outcome phase, we provide reasonable arguments that the lack of effect in the anticipation phase is not due to an inefficient task but points to unexpected behavior of the reward system during pharmacological challenge. Group differences of reward anticipation should therefore not be seen as simple representatives of dopaminergic states.

scholarly journals Contextualized School-Based Cognitive Behavioral Therapy (CBT) Intervention for Malaysian Secondary School Students

2020 ◽  
Vol 11 ◽  
Author(s):  
Jo Anne Saw ◽  
Cai Lian Tam ◽  
Vanlal Thanzami ◽  
Gregory Bonn
Keyword(s):  
Depressive Symptoms ◽  
Secondary School ◽  
Depressive Symptomatology ◽  
Effective Means ◽  
School Context ◽  
Intervention Group ◽  
Control Group ◽  
School Students ◽  
School Based ◽  
Negative Thoughts

This study investigates the effectiveness of the school-based Shine Through Any Roadblocks (STAR) CBT intervention, by a screening conducted on 634 students from eight secondary schools in Malaysia. Participants (n = 85) who fulfilled the eligibility criteria were assigned randomly to either the intervention group (n = 42) or the assessment-only waitlist control group (n = 43). The intervention consisted of eight group-based sessions over a period of 2 months. Sessions were 60-min each and conducted according to the STAR module. Outcome measures (depressive symptoms and automatic negative thoughts) were administered at five intervals: baseline/pre-intervention, mid-intervention, post-intervention, 1-month after intervention, and 3-months after intervention. Results showed significant and lasting lower levels of depressive symptoms and automatic negative thoughts in the intervention group, indicating that the STAR intervention could be an effective means of reducing depressive symptomatology among adolescents. Clinical implications for the Malaysian secondary school context are further discussed.

scholarly journals The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers

2020 ◽  
Vol 34 (9) ◽  
pp. 969-980 ◽  
Author(s):  
Will Lawn ◽  
James Hill ◽  
Chandni Hindocha ◽  
Jocelyn Yim ◽  
Yumeya Yamamori ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Brain Activity ◽  
Neural Correlates ◽  
Monetary Incentive ◽  
Reward Processing ◽  
Delay Task ◽  
Reward Anticipation ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay ◽  
Healthy Participants

Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of reward processing. However, it is unknown whether cannabidiol acutely affects brain function underpinning reward anticipation and feedback. Hypotheses: We predicted that cannabidiol would augment brain activity associated with reward anticipation and feedback. Methods: We administered a single 600 mg oral dose of cannabidiol and matched placebo to 23 healthy participants in a double-blind, placebo-controlled, repeated-measures design. We employed the monetary incentive delay task during functional magnetic resonance imaging to assay the neural correlates of reward anticipation and feedback. We conducted whole brain analyses and region-of-interest analyses in pre-specified reward-related brain regions. Results: The monetary incentive delay task elicited expected brain activity during reward anticipation and feedback, including in the insula, caudate, nucleus accumbens, anterior cingulate and orbitofrontal cortex. However, across the whole brain, we did not find any evidence that cannabidiol altered reward-related brain activity. Moreover, our Bayesian analyses showed that activity in our regions-of-interest was similar following cannabidiol and placebo. Additionally, our behavioural measures of motivation for reward did not show a significant difference between cannabidiol and placebo. Discussion: Cannabidiol did not acutely affect the neural correlates of reward anticipation and feedback in healthy participants. Future research should explore the effects of cannabidiol on different components of reward processing, employ different doses and administration regimens, and test its reward-related effects in people with psychiatric disorders.

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