scholarly journals Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology

2021 ◽  
Author(s):  
Emir Malovic ◽  
Alyssa Ealy ◽  
Arthi Kanthasamy ◽  
Anumantha G Kanthasamy
Keyword(s):  
Heavy Metals ◽  
Environmental Chemicals ◽  
Diverse Range ◽  
Translation Machinery ◽  
Toxic Pollutants ◽  
Chemically Modified ◽  
Scientific Disciplines ◽  
Toxic Responses ◽  
Cognate Mrnas

Abstract Epitranscriptomics, the study of chemically modified RNAs, is a burgeoning field being explored in a variety of scientific disciplines. Of the currently known epitranscriptomic modifications, N6-methyladenosine (m6A) methylation is the most abundant. The m6A modification is predominantly regulated by three tiers of protein modulators classified as writers, erasers, and readers. Depending upon cellular needs, these proteins function to deposit, remove, or read the methyl modifications on cognate mRNAs. Many environmental chemicals including heavy metals, pesticides, and other toxic pollutants, are all known to perturb transcription and translation machinery to exert their toxic responses. As such, we herein review how the m6A modification may be affected under different toxicological paradigms. Furthermore, we discuss how toxicants can affect the three tiers of regulation directly, and how these effects influence the m6A-modified mRNAs. Lastly, we highlight the disparities between published findings and theories, especially those concerning the m6A reader tier of regulation. In the far-reaching field of toxicology, m6A epitranscriptomics provides another enticing avenue to explore new mechanisms and therapies for a diverse range of environmentally linked disorders and diseases.

Climate Change Outcomes on the Environmental Ecotoxicology

2022 ◽  
pp. 1611-1632
Author(s):  
Soraia El Baz
Keyword(s):  
Climate Change ◽  
Heavy Metals ◽  
Environmental Behavior ◽  
Toxic Pollutants ◽  
Climate Fluctuations ◽  
Precipitation And Temperature

Climate change is a daunting problem and has only recently attracted attention. This chapter presents a review on the implications of climate change on the regulation, and modelling of toxic pollutants. Also, it identifies relationships between climate fluctuations and changes in some polluants distribution (heavy metals, hydrocarbons, and pesticides). Moreover, the influence of climate change on polluant environmental behavior is explored by studying polluants response to inter-annual climate fluctuations such as precipitation and temperature. Therefore, it will be important to monitor strategies taking into account climate change and new regulatory plans should be devised in toxics polluant management.

Adsorption behavior of heavy metals onto chemically modified sugarcane bagasse

2010 ◽  
Vol 101 (6) ◽  
pp. 2067-2069 ◽  
Author(s):  
Puspa Lal Homagai ◽  
Kedar Nath Ghimire ◽  
Katsutoshi Inoue
Keyword(s):  
Heavy Metals ◽  
Sugarcane Bagasse ◽  
Adsorption Behavior ◽  
Chemically Modified

scholarly journals A review on experimental chemically modified activated carbon to enhance dye and heavy metals adsorption

2021 ◽  
pp. 100382
Author(s):  
Marzia Sultana ◽  
Mahbub Hasan Rownok ◽  
Meherunnesa Sabrin ◽  
Md Hafezur Rahaman ◽  
S.M.Nur Alam
Keyword(s):  
Heavy Metals ◽  
Activated Carbon ◽  
Modified Activated Carbon ◽  
Chemically Modified ◽  
Heavy Metals Adsorption ◽  
Metals Adsorption

scholarly journals Exploring and Illustrating the (Inter-)Disciplinarity of Waste and Zero Waste Management

Urban Science ◽  
2020 ◽  
Vol 4 (4) ◽  
pp. 73
Author(s):  
Jonathon Hannon
Keyword(s):  
Waste Management ◽  
Theory And Practice ◽  
Community Practice ◽  
Diverse Range ◽  
Zero Waste ◽  
Research Education ◽  
Scientific Disciplines ◽  
Management Approaches ◽  
Interdisciplinary Theory ◽  
Industry Community

The aim of this research was to explore the composition, contribution and arrangement of scientific disciplines, across the spectrum from, traditional waste management, to alternative, contemporary approaches, such as the zero waste and circular economy movements. The purpose of this research is to better address the challenge of waste by enhancing the understanding and future employment of interdisciplinary theory and practice. The first outcome of the review strategy employed in this research was to, illustrate a generic rubric of scientific disciplines and to highlight and discuss key disciplines most obviously connected to waste management. This graphic illustration was then overlain with the findings from systematically reviewing a diverse range of indicators and sources of insight and information on the disciplines and interdisciplinarity evident across the spectrum from waste to zero waste management approaches. The resulting final graphic illustrates the intense disciplinarity and hence, the significant interdisciplinary requirement of (zero) waste management. An observation emerging from this research is that, successfully managing the globalised complexity of waste issues and in this, addressing the challenges of climate change and sustainable development, requires cultivating synergy between multiple scientific and practical disciplines. The scope of this challenge increases with the adoption of more holistic, aspirational, countercultural approaches, such as zero waste. It is argued that, enhancing interdisciplinary training and collaboration in research, education and industry/community practice, will improve performance across the spectrum of worldviews, from waste to zero waste.

scholarly journals Is the Hyporheic Zone Relevant beyond the Scientific Community?

Water ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2230 ◽  
Author(s):  
Jörg Lewandowski ◽  
Shai Arnon ◽  
Eddie Banks ◽  
Okke Batelaan ◽  
Andrea Betterle ◽  
...  
Keyword(s):  
Hyporheic Zone ◽  
Aquatic Organisms ◽  
Ecosystem Functions ◽  
Major Research ◽  
Research Gaps ◽  
Diverse Range ◽  
Scientific Disciplines ◽  
Hyporheic Zones ◽  
Reactive Interface ◽  
River Corridors

Rivers are important ecosystems under continuous anthropogenic stresses. The hyporheic zone is a ubiquitous, reactive interface between the main channel and its surrounding sediments along the river network. We elaborate on the main physical, biological, and biogeochemical drivers and processes within the hyporheic zone that have been studied by multiple scientific disciplines for almost half a century. These previous efforts have shown that the hyporheic zone is a modulator for most metabolic stream processes and serves as a refuge and habitat for a diverse range of aquatic organisms. It also exerts a major control on river water quality by increasing the contact time with reactive environments, which in turn results in retention and transformation of nutrients, trace organic compounds, fine suspended particles, and microplastics, among others. The paper showcases the critical importance of hyporheic zones, both from a scientific and an applied perspective, and their role in ecosystem services to answer the question of the manuscript title. It identifies major research gaps in our understanding of hyporheic processes. In conclusion, we highlight the potential of hyporheic restoration to efficiently manage and reactivate ecosystem functions and services in river corridors.

Organochlorines in Chinese Women: Determinants of Serum Concentrations

2011 ◽  
Vol 183-185 ◽  
pp. 1513-1516
Author(s):  
Wu Wen Lv
Keyword(s):  
Heavy Metals ◽  
Serum Level ◽  
Organochlorine Pesticides ◽  
Organic Pollutants ◽  
Chinese Women ◽  
Serum Levels ◽  
High Serum ◽  
Environmental Chemicals ◽  
Serum Concentrations ◽  
High Serum Level

People are frequently exposed to various environmental chemicals such as organic pollutants, heavy metals, etc. Therefore, the aim of this paper is to investigate the accumulation level of organochlorines in women from Qiqihaer city in china. Of the 160 people investigated, 113 sujects were detected with different serum levels of organochlorine pesticides (range: 0.042 - 33.072 μg/L). Moreover, the results indicated that there was high serum level of accumulated organochlorines pesticides of women in Chinese, and the serum concentrations of organochlorines pesticides was associated with age.

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