scholarly journals Differential effects of omega‐3 and omega‐6 fatty acids on global gene expression of breast cancer

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Nabarun Chakraborty ◽  
Rasha Hammamieh ◽  
Agnes Day ◽  
Marti Jett
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Fatty Acids ◽  
Global Gene Expression ◽  
Omega 3 ◽  
Differential Effects ◽  
Omega 6

Differential Effects of Omega-3 and Omega-6 fatty Acids on Gene Expression in Breast Cancer Cells

2006 ◽  
Vol 101 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Rasha Hammamieh ◽  
Nabarun Chakraborty ◽  
Stacy-Ann Miller ◽  
Edward Waddy ◽  
Mohsen Barmada ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Fatty Acids ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Omega 3 ◽  
Differential Effects ◽  
Omega 6

scholarly journals Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases

2020 ◽  
Vol 21 (3) ◽  
pp. 741 ◽  
Author(s):  
Anamaria Balić ◽  
Domagoj Vlašić ◽  
Kristina Žužul ◽  
Branka Marinović ◽  
Zrinka Bukvić Mokos
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Skin Diseases ◽  
Inflammatory Responses ◽  
Omega 3 ◽  
Inflammatory Skin Diseases ◽  
Prevention And Treatment ◽  
Omega 6 ◽  
Inflammatory Skin

Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.

scholarly journals Structural Insight into the Differential Effects of Omega-3 and Omega-6 Fatty Acids on the Production of Aβ Peptides and Amyloid Plaques

2010 ◽  
Vol 286 (8) ◽  
pp. 6100-6107 ◽  
Author(s):  
Zareen Amtul ◽  
Markus Uhrig ◽  
Richard F. Rozmahel ◽  
Konrad Beyreuther
Keyword(s):  
Fatty Acids ◽  
Amyloid Plaques ◽  
Omega 3 ◽  
Aβ Peptides ◽  
Differential Effects ◽  
Omega 6 ◽  
Structural Insight ◽  
Insight Into

scholarly journals Multicenter Randomized Controlled Trial of Omega-3 Fatty Acids Versus Omega-6 Fatty Acids for the Control of Cancer-Related Fatigue Among Breast Cancer Survivors

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Luke J Peppone ◽  
Julia E Inglis ◽  
Karen M Mustian ◽  
Charles E Heckler ◽  
Gilbert D A Padula ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Mrna Levels ◽  
Omega 3 ◽  
Symptom Index ◽  
Cancer Related Fatigue ◽  
Brief Fatigue Inventory ◽  
Omega 6

Abstract Background Cancer-related fatigue (CRF) is a common side effect of adjuvant therapy and becomes a chronic problem for approximately one-third of survivors. Omega-3 polyunsaturated fatty acids (O3-PUFA) demonstrated preliminary antifatigue effects in previous research, but have not been investigated in fatigued cancer survivors. Methods Breast cancer survivors 4–36 months posttreatment with a CRF score of 4 or more of 10 using the symptom inventory (SI) were randomly assigned to O3-PUFA (fish oil, 6 g/d), omega-6 PUFA (O6-PUFA; soybean oil, 6 g/d), or a low-dose combination of O3-/O6-PUFA (3 g/d O3-PUFA and O6-PUFA) for 6 weeks. CRF was assessed by the SI (screening question), the Brief Fatigue Inventory, and the Multidimensional Fatigue Symptom Index. Protein and mRNA levels of inflammatory and antioxidant biomarkers, along with fatty acid and lipid levels, were assessed at baseline and week 6. Statistical tests were two-sided. Results A total of 108 breast cancer survivors consented; 97 subjects were randomly assigned and 81 completed the trial. The SI CRF score decreased by 2.51 points at week 6 with O6-PUFA and by 0.93 points with O3-PUFA, with statistically significant between-group difference (effect size = −0.86, P < .01). Similar changes were observed for the Brief Fatigue Inventory and Multidimensional Fatigue Symptom Index but were not statistically significant. Stratified analyses showed the largest benefit was observed in those with severe baseline CRF (≥7). Compared with O3-PUFA, O6-PUFA supplementation statistically significantly decreased proinflammatory markers in the TNF-α signaling pathway. Conclusion Contrary to our original hypothesis, O6-PUFA statistically significantly reduced CRF compared with O3-PUFA. Further research is needed to confirm these findings and to elucidate mechanisms of action.

Omega-3 and Omega-6 Fatty Acids and Breast Cancer

2011 ◽  
pp. 91-98
Author(s):  
Alvaro Luis Ronco ◽  
Eduardo De Stéfani
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Omega 3 ◽  
Omega 6
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