scholarly journals Functional Role of Microbiota‐derived Metabolites in the GPCR‐mediated Regulation of Intestinal Wound Healing and Barrier Function

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Ashfaqul Alam ◽  
Darra Boyer ◽  
Jason Matthews ◽  
Bejan Saeedi ◽  
Huixia Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Barrier Function ◽  
Functional Role

scholarly journals Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process

2015 ◽  
Vol 14 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Christopher Dunnill ◽  
Thomas Patton ◽  
James Brennan ◽  
John Barrett ◽  
Matthew Dryden ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Functional Role ◽  
Healing Process ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals MiR-200c-3p aggravates gastric cell carcinoma via KLF6

2021 ◽  
Vol 43 (11) ◽  
pp. 1307-1316
Author(s):  
Ying Wang ◽  
Kaijuan Lu ◽  
Weibing Li ◽  
Zhigang Wang ◽  
Jing Ding ◽  
...  
Keyword(s):  
Wound Healing ◽  
Western Blot ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Functional Role ◽  
Migration And Invasion ◽  
Expression Levels ◽  
Qrt Pcr ◽  
Gastric Cell

Abstract Background Gastric cell carcinoma (GCC) is a common and high-incidence malignant gastrointestinal cancer that seriously threatens human life and safety. Evidences suggest that microRNAs (miRNAs) exhibit an essential role in regulating the occurrence and development of GCC, while the effects and possible mechanisms remain to be further explored. Objective This study was designed to explore whether miR-200c-3p exerted its functional role in the growth and metastasis of GCC, and investigate the possible mechanisms. Methods The expression levels of miR-200c-3p in GCC tissues and cell lines were detected by qRT-PCR analysis. The functional role of miR-200c-3p in the viability, proliferation, migration and invasion of GCC cells were evaluated by CCK-8, EdU, wound healing and Transwell assays. In addition, the candidate targets of miR-200c-3p was predicted and confirmed by dual-luciferase reporter assay. Moreover, the relationship between miR-200c-3p and target (Krüppel like factor 6, KLF6) was assessed by qRT-PCR and western blot assays. Besides, the expression levels of KLF6 in GCC cells were determined by qRT-PCR and western blot assays. Furthermore, the role of KLF6 in the viability, proliferation, migration and invasion of GCC cells mediated with miR-200c-3p mimics was evaluated by CCK-8, EdU, wound healing and Transwell assays. Results In the present study, a new tumor promoting function of miR-200c-3p was disclosed in GCC. We found that the expression of miR-200c-3p was obviously increased in clinic GCC tissues and cell lines. In addition, down-regulation of miR-200c-3p suppressed cell viability, proliferation, migration, and invasion in GCC cells. Moreover, KLF6 was verified as a direct target of miR-200c-3p by binding its 3’-UTR. Additionally, KLF6 was remarkably decreased and was negatively associated with the miR-200c-3p expression in GCC cell lines. Furthermore, over-expression of KLF6 retarded the effects of miR-200c-3p on the growth and metastasis of GCC cell lines. Conclusions MiR-200c-3p potentially played a tumor-promoting role in the occurrence and development of GCC, which may be achieved by targeting KLF6. Graphic abstract

Functional Role of PPARδ in Corneal Epithelial Wound Healing

2012 ◽  
Vol 180 (2) ◽  
pp. 583-598 ◽  
Author(s):  
Yoshikuni Nakamura ◽  
Takahiro Nakamura ◽  
Takeshi Tarui ◽  
Jun Inoue ◽  
Shigeru Kinoshita
Keyword(s):  
Wound Healing ◽  
Functional Role ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

Neutrophil function in the healing wound: adding insult to injury?

2004 ◽  
Vol 92 (08) ◽  
pp. 275-280 ◽  
Author(s):  
Julia Dovi ◽  
Anna Szpaderska ◽  
Luisa DiPietro
Keyword(s):  
Wound Healing ◽  
Innate Immune System ◽  
Functional Role ◽  
Wound Closure ◽  
Inflammatory Cells ◽  
Neutrophil Function ◽  
Innate Immune ◽  
Normal Wound Healing ◽  
Healing Wound

SummaryCells of the innate immune system, including neutrophils and macrophages, are a highly visible component of normal wound healing in adult mammals. The role of inflammatory cells in the healing wound has been widely investigated, and evidence for both positive and negative influences exists. Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure. This developing information suggests that the functional role of inflammatory cells in wound healing must be reevaluated.

scholarly journals Role of gut microbiota in intestinal wound healing and barrier function

2018 ◽  
Vol 6 (3) ◽  
pp. 1539595 ◽  
Author(s):  
Ashfaqul Alam ◽  
Andrew Neish
Keyword(s):  
Wound Healing ◽  
Gut Microbiota ◽  
Barrier Function

Expression and functional role of c-Kit and erbB2 in human hepatoblastoma.

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
B Steiger ◽  
I Leuschner ◽  
D Denkhaus ◽  
D von Schweinitz ◽  
T Pietsch
Keyword(s):  
Functional Role

Questions on the role of biofilms for the adaptation of microorganisms to unfavorable environmental factors by the example of P. aeruginosa

2020 ◽  
Vol 99 (4) ◽  
pp. 379-383
Author(s):  
Vasily N. Afonyushkin ◽  
N. A. Donchenko ◽  
Ju. N. Kozlova ◽  
N. A. Davidova ◽  
V. Yu. Koptev ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Environmental Factors ◽  
Barrier Function ◽  
Infectious Agent ◽  
Antagonistic Activity ◽  
The Body ◽  
Main Function ◽  
Pathogenic Potential ◽  
The Face

Pseudomonas aeruginosa is a widely represented species of bacteria possessing of a pathogenic potential. This infectious agent is causing wound infections, fibrotic cystitis, fibrosing pneumonia, bacterial sepsis, etc. The microorganism is highly resistant to antiseptics, disinfectants, immune system responses of the body. The responses of a quorum sense of this kind of bacteria ensure the inclusion of many pathogenicity factors. The analysis of the scientific literature made it possible to formulate four questions concerning the role of biofilms for the adaptation of P. aeruginosa to adverse environmental factors: Is another person appears to be predominantly of a source an etiological agent or the source of P. aeruginosa infection in the environment? Does the formation of biofilms influence on the antibiotic resistance? How the antagonistic activity of microorganisms is realized in biofilm form? What is the main function of biofilms in the functioning of bacteria? A hypothesis has been put forward the effect of biofilms on the increase of antibiotic resistance of bacteria and, in particular, P. aeruginosa to be secondary in charcter. It is more likely a biofilmboth to fulfill the function of storing nutrients and provide topical competition in the face of food scarcity. In connection with the incompatibility of the molecular radii of most antibiotics and pores in biofilm, biofilm is doubtful to be capable of performing a barrier function for protecting against antibiotics. However, with respect to antibodies and immunocompetent cells, the barrier function is beyond doubt. The biofilm is more likely to fulfill the function of storing nutrients and providing topical competition in conditions of scarcity of food resources.

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