Upregulation of Prokineticin 2 and Prokineticin Receptor 1 in low shear stress‐induced vascular remodeling in mice

In early atherosclerosis, plaques localize in low shear stress regions. During plaque development, the lumen of the artery remains patent due to vascular remodeling and unfavorable low shear stress conditions can persist. Consequently, a continuous influx of lipids can be anticipated in these regions, possibly leading to the development vulnerable plaques. If the plaque exceeds a certain size, vascular remodeling will not be able to maintain the lumen dimensions and the plaque will cause lumen narrowing. This is generally accompanied by shear stress increase in certain regions of the plaque. Evidence is accumulating that increased levels of shear stress influences plaque composition in such a way that it might induce plaque destabilization and ulcer formation.

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Restoration of endothelial autophagic flux in vascular endothelial cells exposed to low shear stress reduces atherosclerotic lesions

Archives of Cardiovascular Diseases Supplements ◽

10.1016/j.acvdsp.2021.04.078 ◽

2021 ◽

Vol 13 (2) ◽

pp. 177

Author(s):

S. Chatterjee ◽

M. Kheloufi ◽

S. Mazlan ◽

X. Loyer ◽

T. Mckinsey ◽

...

Keyword(s):

Endothelial Cells ◽

Shear Stress ◽

Vascular Endothelial Cells ◽

Autophagic Flux ◽

Vascular Endothelial ◽

Atherosclerotic Lesions ◽

Low Shear Stress ◽

Low Shear

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Structure of high and low shear-stress events in a turbulent boundary layer

Physical Review Fluids ◽

10.1103/physrevfluids.3.014609 ◽

2018 ◽

Vol 3 (1) ◽

Cited By ~ 7

Author(s):

G. Gomit ◽

R. de Kat ◽

B. Ganapathisubramani

Keyword(s):

Boundary Layer ◽

Shear Stress ◽

Turbulent Boundary Layer ◽

Low Shear Stress ◽

Low Shear

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Low shear stress-induced endothelial mesenchymal transformation via the down-regulation of TET2

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2021.01.062 ◽

2021 ◽

Vol 545 ◽

pp. 20-26

Author(s):

AFang Li ◽

LiLan Tan ◽

ShuLei Zhang ◽

Jun Tao ◽

Zuo Wang ◽

...

Keyword(s):

Shear Stress ◽

Down Regulation ◽

Low Shear Stress ◽

Mesenchymal Transformation ◽

Low Shear

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Plaque and Shear Stress Distribution in Human Coronary Bifurcations: a Multi-Slice Computed Tomography Study

ASME 2007 Summer Bioengineering Conference ◽

10.1115/sbc2007-176309 ◽

2007 ◽

Cited By ~ 1

Author(s):

Alina G. van der Giessen ◽

Jolanda J. Wentzel ◽

Frans N. van de Vosse ◽

Antonius F. van der Steen ◽

Pim J. de Feyter ◽

...

Keyword(s):

Computed Tomography ◽

Shear Stress ◽

Outer Wall ◽

Atherosclerotic Plaques ◽

Advanced Stage ◽

Flow Divider ◽

Low Shear Stress ◽

Curved Vessels ◽

Early Atherosclerosis ◽

Low Shear

It is generally accepted that early atherosclerosis develops in low shear-stress (SS) regions such as the outer wall of arterial bifurcations and the inner bend of curved vessels (1). However, in clinical practice, it is common to observe atherosclerotic plaques at the flow-divider, or carina, of coronary bifurcations (2). Plaques at the carina are more frequently found in symptomatic patients, and may represent a more advanced stage of atherosclerosis. The carina is located in a region which is exposed to high SS. We hypothesize that if plaques are located in atheroprotective high SS regions, they have grown circumferentially from the atherogenic low SS regions.

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