scholarly journals Protective Effect of Astragalus Polysaccharide Against High glucose‐induced Endoplasmic Reticulum Stress by Activation of AMP‐activated Protein Kinase in Human HepG2 Cells

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Jian Liu ◽  
Huan Jin ◽  
Juan Deng ◽  
Jingping Ouyang
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Kinase ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
High Glucose ◽  
Hepg2 Cells ◽  
Astragalus Polysaccharide ◽  
Amp Activated Protein Kinase

Protective effect of curcumin against high glucose-induced endoplasmic reticulum stress by downregulation of COX-2 expression in huvecs

2008 ◽  
Vol 32 (3) ◽  
pp. S14-S14
Author(s):  
Ying Fan ◽  
Xiang Hong Meng ◽  
Wen Liang Chen ◽  
Li Zhu ◽  
Yue Liang Shen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
High Glucose ◽  
Cox 2

Fish oil supplementation inhibits endoplasmic reticulum stress and improves insulin resistance: involvement of AMP-activated protein kinase

2017 ◽  
Vol 8 (4) ◽  
pp. 1481-1493 ◽  
Author(s):  
Wenqi Yang ◽  
Xu Chen ◽  
Ming Chen ◽  
Yanping Li ◽  
Qing Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Protein Kinase ◽  
Endoplasmic Reticulum Stress ◽  
Fish Oil ◽  
Er Stress ◽  
Protective Effects ◽  
Ampk Activation ◽  
Amp Activated Protein Kinase ◽  
Fish Oil Supplementation

ER stress inhibition through AMPK activation may explain the protective effects of fish oil against HFD-induced insulin resistance.

scholarly journals Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Taewon Yuk ◽  
Younghwa Kim ◽  
Jinwoo Yang ◽  
Jeehye Sung ◽  
Heon Sang Jeong ◽  
...  
Keyword(s):  
Protein Kinase ◽  
High Glucose ◽  
Lipid Accumulation ◽  
Hepg2 Cells ◽  
Fatty Acid Synthase ◽  
Regulatory Element ◽  
Hepatic Lipogenesis ◽  
Nonalcoholic Fatty Liver ◽  
Compound C ◽  
Amp Activated Protein Kinase

We aimed to investigate the effects of nobiletin on hepatic lipogenesis in high glucose-induced lipid accumulation in HepG2 cells. Nobiletin, a citrus polymethoxyflavonoid with six methoxy groups, is present abundantly in the peels of citrus fruits. HepG2 cells were incubated in Dulbecco’s modified Eagle’s medium containing high glucose (25 mM) and subsequently treated with nobiletin at different concentrations (5, 25, and 50 μM). Results showed that nobiletin markedly inhibited high glucose-induced hepatic lipid accumulation in HepG2 cells. In addition, it reduced the protein expression of lipogenic factors, including sterol regulatory element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS). Nobiletin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase. Pretreatment with compound C, an AMPK inhibitor, abolished the inhibitory effects of nobiletin on SREBP-1c and FAS expression. These results suggested that nobiletin might attenuate high glucose-induced lipid accumulation in HepG2 hepatocytes via modulation of AMPK signaling pathway. Therefore, nobiletin might be useful for the prevention and treatment of nonalcoholic fatty liver diseases.

scholarly journals Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

Diabetes ◽  
2010 ◽  
Vol 59 (6) ◽  
pp. 1386-1396 ◽  
Author(s):  
Y. Dong ◽  
M. Zhang ◽  
S. Wang ◽  
B. Liang ◽  
Z. Zhao ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Protein Kinase ◽  
Endoplasmic Reticulum Stress ◽  
Oxidized Ldl ◽  
Amp Activated Protein Kinase

scholarly journals Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells

2019 ◽  
Vol 52 (2) ◽  
pp. 176
Author(s):  
Shalom Sara Thomas ◽  
Sora Park ◽  
Youn-Soo Cha ◽  
Kyung-Ah Kim
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Palmitic Acid ◽  
Hepg2 Cells
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