scholarly journals Characterization of FasL expression of rat Mesenteric Lymph Node Dendritic Cells during Inflammatory Bowel Disease (IBD)

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Edelmarie Rivera ◽  
Freddy Rodriguez ◽  
Caroline Barbara Appleyard
Keyword(s):  
Inflammatory Bowel Disease ◽  
Dendritic Cells ◽  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Bowel Disease ◽  
Fasl Expression ◽  
Mesenteric Lymph ◽  
Inflammatory Bowel

Effects of Tumor Necrosis Factor Alpha Inhibitors on Lymph Node and Ileocecal Mucosa-Associated Lymphoid Tissue Architecture in Patients With Inflammatory Bowel Disease

2019 ◽  
Vol 23 (2) ◽  
pp. 115-120
Author(s):  
Virginia E Duncan ◽  
Karen M Chisholm ◽  
M Cristina Pacheco
Keyword(s):  
Inflammatory Bowel Disease ◽  
Lymph Node ◽  
Germinal Center ◽  
Bowel Disease ◽  
Lymphoid Tissue ◽  
Ileocecal Valve ◽  
Tissue Architecture ◽  
Mesenteric Lymph ◽  
Tnfα Inhibitors ◽  
Inflammatory Bowel

Background Antitumor necrosis alpha (TNFα) therapy is often used in the management of patients with inflammatory bowel disease (IBD) and may have effects on lymphoid tissue architecture and function. The goal of our study was to characterize the effects of TNFα inhibitors on mesenteric lymph node and mucosa-associated lymphoid tissue in patients with IBD. Methods We examined lymphoid tissue morphology in IBD patients treated with TNFα inhibitors compared to untreated controls. Intestinal resections from 19 patients (10 anti-TNFα treated and 9 controls) were reviewed. Immunohistochemistry for CD21, CD20, and CD3 was performed on ileocecal valve lymphoid tissue and mesenteric lymph nodes from the resection specimens to assess follicular architecture. Results Relative to control groups, TNFα-treated groups showed less preserved germinal center architecture, evidenced by lower overall semiquantitative scores for follicular architecture. Likewise, the percentage of secondary follicles to total follicles was decreased in patients treated with TNFα blockade. Conclusions Our results suggest that TNFα inhibitors may play a role in disruption of lymphoid germinal center architecture in patients with IBD. Awareness of this disrupted lymphoid morphology when examining histologic sections from patients with IBD treated with TNFα inhibitors may prevent unnecessary studies to exclude a lymphoproliferative disorder.

Phenotypic and functional analysis of dendritic cells isolated from the mesenteric lymph nodes of human inflammatory bowel disease

2003 ◽  
Vol 124 (4) ◽  
pp. A322
Author(s):  
Atsushi Sakuraba ◽  
Toshiro Sato ◽  
Yuuichi Morohoshi ◽  
Shigeo Yoshizawa ◽  
Yuusuke Kishi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Functional Analysis ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Bowel Disease ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Human Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Characterization of Helicobacter-induced inflammatory bowel disease in IL-10 -/- and T cell deficient mice

2001 ◽  
Vol 120 (5) ◽  
pp. A523-A523
Author(s):  
A BURICH ◽  
R HERSHBERG ◽  
K WAGGIE ◽  
W ZENG ◽  
J VINEY ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Deficient Mice

scholarly journals Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model

2020 ◽  
Vol 22 (1) ◽  
pp. 364
Author(s):  
Qiyuan Han ◽  
Thomas J. Y. Kono ◽  
Charles G. Knutson ◽  
Nicola M. Parry ◽  
Christopher L. Seiler ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gastrointestinal Disease ◽  
Tumor Development ◽  
Proximal Colon ◽  
Helicobacter Hepaticus ◽  
Reduced Representation ◽  
Reduced Representation Bisulfite Sequencing ◽  
Inflammatory Bowel

Epigenetic dysregulation is hypothesized to play a role in the observed association between inflammatory bowel disease (IBD) and colon tumor development. In the present work, DNA methylome, hydroxymethylome, and transcriptome analyses were conducted in proximal colon tissues harvested from the Helicobacter hepaticus (H. hepaticus)-infected murine model of IBD. Reduced representation bisulfite sequencing (RRBS) and oxidative RRBS (oxRRBS) analyses identified 1606 differentially methylated regions (DMR) and 3011 differentially hydroxymethylated regions (DhMR). These DMR/DhMR overlapped with genes that are associated with gastrointestinal disease, inflammatory disease, and cancer. RNA-seq revealed pronounced expression changes of a number of genes associated with inflammation and cancer. Several genes including Duox2, Tgm2, Cdhr5, and Hk2 exhibited changes in both DNA methylation/hydroxymethylation and gene expression levels. Overall, our results suggest that chronic inflammation triggers changes in methylation and hydroxymethylation patterns in the genome, altering the expression of key tumorigenesis genes and potentially contributing to the initiation of colorectal cancer.

Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease

1994 ◽  
Vol 39 (9) ◽  
pp. 1893-1899 ◽  
Author(s):  
Jeffrey S. Hyams ◽  
John E. Fitzgerald ◽  
Nancy Wyzga ◽  
William R. Treem ◽  
Christopher J. Justinich ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Receptor Antagonist ◽  
Bowel Disease ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Inflammatory Bowel

Characterization of Anti-Lymphocyte Antibodies in Inflammatory Bowel Disease

1976 ◽  
Vol 5 (6-7) ◽  
pp. 837-844 ◽  
Author(s):  
C. A. HENDERSON ◽  
L. GREENLEE ◽  
R. C. WILLIAMS ◽  
R.G. STRICKLAND
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals IFN-γ Secreted by CD103+Dendritic Cells Leads to IgG Generation in the Mesenteric Lymph Node in the Absence of Vitamin A

2011 ◽  
Vol 186 (12) ◽  
pp. 6999-7005 ◽  
Author(s):  
Jae-Hoon Chang ◽  
Hye-Ran Cha ◽  
Sun-Young Chang ◽  
Hyun-Jeong Ko ◽  
Sang-Uk Seo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
Vitamin A ◽  
Mesenteric Lymph Node ◽  
Mesenteric Lymph ◽  
Ifn Γ
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