scholarly journals Nicotine stimulates retinal angiogenesis via α7‐nicotinic receptor and matrix metalloproteinases (MMP)‐mediated signaling pathway

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Adam W. Buckley ◽  
Kathleen C. Brown ◽  
Aaron M. Dom ◽  
Donald W. Weller ◽  
Yashoni H. Shah ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Signaling Pathway ◽  
Nicotinic Receptor ◽  
Retinal Angiogenesis

scholarly journals The TLR-2/TonEBP signaling pathway regulates 29-kDa fibronectin fragment-dependent expression of matrix metalloproteinases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyun Sook Hwang ◽  
Mi Hyun Lee ◽  
Hyun Ah Kim
Keyword(s):  
Matrix Metalloproteinases ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Nuclear Accumulation ◽  
Activated T Cells ◽  
Inflammatory Conditions ◽  
Enhancer Binding Protein ◽  
Fibronectin Fragments ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels

AbstractTonicity-responsive enhancer-binding protein (TonEBP; nuclear factor of activated T cells 5) is a transcription factor that responds to changes in osmolality. However, recent studies have shown that it also modulates immune responses under inflammatory conditions independently of hyperosmolality. Fibronectin fragments (FN-fs), which are abundant in the synovial fluid of patients with osteoarthritis (OA), induce expression of matrix metalloproteinases (MMPs) via the toll-like receptor-2 (TLR-2) signaling pathway. In this study we examined whether TonEBP is involved in 29-kDa FN-f-induced expression of MMPs. The expression of TonEBP was significantly higher in human osteoarthritis compared with normal cartilage samples. 29-kDa FN-f affected the expression of MMPs 1, 3, and 13 via TonEBP, and expression and nuclear accumulation of TonEBP were induced by activation of the phospholipase C/NF-κB/MAPK signaling pathway and, in particular, modulated by TLR-2. In addition, 29-kDa FN-f induced the expression of osmoregulatory genes, including Tau-T, SMIT, and AR, as well as voltage-dependent calcium channels via the TonEBP/TLR-2 signaling pathway. These results show that 29-kDa FN-f upregulates MMPs in chondrocytes via the TLR-2/TonEBP signaling pathway.

scholarly journals Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway

2016 ◽  
Vol 20 (5) ◽  
pp. 533 ◽  
Author(s):  
Jung Min Ha ◽  
Seo Yeon Jin ◽  
Hye Sun Lee ◽  
Hwa Kyoung Shin ◽  
Dong Hyung Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Signaling Pathway ◽  
Endothelial Nitric Oxide Synthase ◽  
Retinal Angiogenesis ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-κB Signaling Pathway in DRG Neurons

2018 ◽  
Vol 10 (1) ◽  
pp. 497-506 ◽  
Author(s):  
Longsheng Xu ◽  
Xiaoping Zhang ◽  
Qingli Feng ◽  
Ying Zheng ◽  
Huadong Ni ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Nicotinic Receptor ◽  
Drg Neurons ◽  
Alpha 7

The TLR-2/TonEBP Signaling Pathway Regulates 29-kDa Fibronectin Fragment-dependent Expression of Matrix Metalloproteinases

2021 ◽  
Author(s):  
Hyun Sook Hwang ◽  
Mi Hyun Lee ◽  
Hyun Ah Kim
Keyword(s):  
Matrix Metalloproteinases ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Nuclear Accumulation ◽  
Activated T Cells ◽  
Inflammatory Conditions ◽  
Enhancer Binding Protein ◽  
Fibronectin Fragments ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels

Abstract Tonicity-responsive enhancer-binding protein (TonEBP; nuclear factor of activated T cells 5) is a transcription factor that responds to changes in osmolality. However, recent studies have shown that it also modulates immune responses under inflammatory conditions independently of hyperosmolality. Fibronectin fragments (FN-fs), which are abundant in the synovial fluid of patients with osteoarthritis (OA), induce expression of matrix metalloproteinases (MMPs) via the toll-like receptor-2 (TLR-2) signaling pathway. In this study we examined whether TonEBP is involved in 29-kDa FN-f-induced expression of MMPs. The expression of TonEBP was significantly higher in human osteoarthritis compared with normal cartilage samples. 29-kDa FN-f affected the expression of MMPs 1, 3, and 13 via TonEBP, and expression and nuclear accumulation of TonEBP were induced by activation of the phospholipase C/NF-κB/MAPK signaling pathway and, in particular, modulated by TLR-2. In addition, 29-kDa FN-f induced the expression of osmoregulatory genes, including Tau-T, SMIT, and AR, as well as voltage-dependent calcium channels via the TonEBP/TLR-2 signaling pathway. These results show that 29-kDa FN-f upregulates MMPs in chondrocytes via the TLR-2/TonEBP signaling pathway.

scholarly journals Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway

2016 ◽  
Vol 48 (6) ◽  
pp. e240-e240 ◽  
Author(s):  
Jung Min Ha ◽  
Seung Hoon Baek ◽  
Young Hwan Kim ◽  
Seo Yeon Jin ◽  
Hye Sun Lee ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Signaling Pathway ◽  
Retinal Angiogenesis
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