scholarly journals Anti‐inflammatory effect of bee venom in amyotrophic lateral sclerosis model

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Eun Jin Yang ◽  
Jing Hua Jiang ◽  
Sang Min Lee ◽  
Myeong Soo Lee ◽  
Sun Mi Choi
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Bee Venom ◽  
Anti Inflammatory ◽  
Lateral Sclerosis ◽  
Inflammatory Effect

41. Anti-Inflammatory Effect of Honey Bee Venom on Wistar Rats Induced Poly Cystic Ovarian Syndrome by Estradiol Valerate

Toxicon ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 115-116
Author(s):  
Mohammad Nabiuni ◽  
Kazem Parivar ◽  
Bahman Zeynali ◽  
Azar Sheikholeslami ◽  
Latifeh Karimzadeh
Keyword(s):  
Honey Bee ◽  
Wistar Rats ◽  
Bee Venom ◽  
Estradiol Valerate ◽  
Anti Inflammatory ◽  
Ovarian Syndrome ◽  
Inflammatory Effect

scholarly journals Bee Venom Pretreatment Has Both an Antinociceptive and Anti-Inflammatory Effect on Carrageenan-Induced Inflammation.

2001 ◽  
Vol 63 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Jang-Hern LEE ◽  
Young-Bae KWON ◽  
Ho-Jae HAN ◽  
Woung-Chon MAR ◽  
Hye-Jung LEE ◽  
...  
Keyword(s):  
Bee Venom ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models

2010 ◽  
Vol 7 (1) ◽  
pp. 69 ◽  
Author(s):  
Eun Jin Yang ◽  
Jing Hua Jiang ◽  
Sang Min Lee ◽  
Sun Choel Yang ◽  
Hye Suk Hwang ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Bee Venom ◽  
Lateral Sclerosis

Effect of non‐steroidal anti‐inflammatory medications on the risk of amyotrophic lateral sclerosis

2007 ◽  
Vol 8 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Rita A. Popat ◽  
Caroline M. Tanner ◽  
Stephen K. van den Eeden ◽  
Allan L. Bernstein ◽  
Daniel A. Bloch ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Anti Inflammatory ◽  
Lateral Sclerosis

scholarly journals IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael R. Strickland ◽  
Kristen R. Ibanez ◽  
Mariya Yaroshenko ◽  
Carolina Ceballos Diaz ◽  
David R. Borchelt ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Chemokine Receptor ◽  
Inflammatory Cytokine ◽  
Disease Onset ◽  
Interleukin 10 ◽  
Inflammatory Chemokines ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine ◽  
Lateral Sclerosis

AbstractInflammatory signaling is thought to modulate the neurodegenerative cascade in amyotrophic lateral sclerosis (ALS). We have previously shown that expression of Interleukin-10 (IL-10), a classical anti-inflammatory cytokine, extends lifespan in the SOD1-G93A mouse model of familial ALS. Here we test whether co-expression of the decoy chemokine receptor M3, that can scavenge inflammatory chemokines, augments the efficacy of IL-10. We found that recombinant adeno-associated virus (AAV)-mediated expression of IL-10, alone, or in combination with M3, resulted in modest extension of lifespan relative to control SOD1-G93A cohort. Interestingly neither AAV-M3 alone nor AAV-IL-10 + AAV-M3 extend survival beyond that of the AAV-IL-10 alone cohort. Focused transcriptomic analysis revealed induction of innate immunity and phagocytotic pathways in presymptomatic SOD1-G93A mice expressing IL-10 + M3 or IL-10 alone. Further, while IL-10 expression increased microglial burden, the IL-10 + M3 group showed lower microglial burden, suggesting that M3 can successfully lower microgliosis before disease onset. Our data demonstrates that over-expression of an anti-inflammatory cytokine and a decoy chemokine receptor can modulate inflammatory processes in SOD1-G93A mice, modestly delaying the age to paralysis. This suggests that multiple inflammatory pathways can be targeted simultaneously in neurodegenerative disease and supports consideration of adapting these approaches to treatment of ALS and related disorders.

scholarly journals Traditional Korean Medicine Treatment for Patients with Wilting Disorder: A Literature Review of In Vivo Studies

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Sung-Jin Kim ◽  
Yeon-Cheol Park ◽  
Yong-Hyeon Baek ◽  
Byung-Kwan Seo
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Herbal Medicine ◽  
Myasthenia Gravis ◽  
Bee Venom ◽  
Guillain Barre Syndrome ◽  
In Vivo Studies ◽  
Traditional Korean Medicine ◽  
Korean Medicine ◽  
Lateral Sclerosis

Wilting disorder is an abnormal condition characterized by weakness and paralysis of the upper and lower extremities. Pathogenesis and treatment target of the disorder are unclear; hence, allopathic treatment is generally used to relieve the symptoms. To investigate the treatment mechanism and effect of Traditional Korean Medicine (TKM) in patients with wilting disorder, we reviewed in vivo studies that focused on the effect of TKM on the main symptoms of wilting disorder and treatment of the diseases that can cause these symptoms. We electronically searched the PubMed, Cochrane, and CNKI (China National Knowledge Infrastructure) databases using the following search terms: (weakness OR motor function disorder) (myasthenia gravis OR Guillain-Barre syndrome OR amyotrophic lateral sclerosis OR paralysis OR polymyositis OR muscular dystrophy) AND (herbal medicine OR acupuncture OR bee-venom OR pharmacoacupuncture OR electro-acupuncture OR moxibustion). We selected 11 studies that demonstrated the effect of TKM treatment on the main symptoms of wilting disorder. In these studies, inducted models of amyotrophic lateral sclerosis, myasthenia gravis, Duchenne muscular atrophy, polymyositis, and Guillain-Barre syndrome were used. With regard to treatment, herbal medicine was used in five studies, and acupuncture and bee-venom pharmacoacupuncture were used in three studies each. Future research is needed to determine the effectiveness of TKM treatment in patients with diseases that can cause the main symptoms of wilting disorder.

The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis

2015 ◽  
Vol 263 ◽  
pp. 91-101 ◽  
Author(s):  
Stéphanie Goursaud ◽  
Sabrina Schäfer ◽  
Amélie O. Dumont ◽  
Maxime Vergouts ◽  
Alessandro Gallo ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Rat Model ◽  
Disease Onset ◽  
Anti Inflammatory ◽  
Lateral Sclerosis

scholarly journals Anti-Inflammatory Effect of Wasp Venom in BV-2 Microglial Cells in Comparison with Bee Venom

Insects ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 297
Author(s):  
Hyun Seok Yun ◽  
Jisun Oh ◽  
Ji Sun Lim ◽  
Hyo Jung Kim ◽  
Jong-Sang Kim
Keyword(s):  
Nitric Oxide ◽  
Nuclear Translocation ◽  
Therapeutic Potential ◽  
Bee Venom ◽  
Microglial Cells ◽  
Wasp Venom ◽  
Freeze Dried ◽  
Cellular Inflammatory Response ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The aim of this study was to compare the anti-inflammatory effect of wasp venom (WV) from the yellow-legged hornet (Vespa velutina) with that of bee venom (BV) on BV-2 murine microglial cells. WV was collected from the venom sac, freeze-dried, and used for in vitro examinations. WV and BV were non-toxic to BV-2 cells at concentrations of 160 and 12 µg/mL or lower, respectively. Treatment with WV reduced the secretion of nitric oxide and proinflammatory cytokines, including interleukin-6 and tumor necrosis factor alpha, from BV-2 cells activated by lipopolysaccharide (LPS). Western blot analysis revealed that WV and BV decreased the expression levels of inflammation markers, including inducible nitric oxide synthase and cyclooxygenase-2. In addition, WV decreased the nuclear translocation of nuclear factor κB (NF-κB), which is a key transcription factor in the regulation of cellular inflammatory response. Cumulatively, the results demonstrated that WV inhibited LPS-induced neuroinflammation in microglial cells by suppressing the NF-κB-mediated signaling pathway, which warrants further studies to confirm its therapeutic potential for neurodegenerative diseases.

scholarly journals KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis

2017 ◽  
Vol 18 (4) ◽  
pp. 487 ◽  
Author(s):  
Myung Geun Kook ◽  
Soon Won Choi ◽  
Yoojin Seo ◽  
Dong Woung Kim ◽  
Bong Keun Song ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Amyotrophic Lateral Sclerosis ◽  
Anti Inflammatory ◽  
Lateral Sclerosis
Sign in / Sign up

Export Citation Format

Share Document