scholarly journals Effect of a Vitamin D supplement on circulating Vitamin D status in pre‐ and post‐menopausal women: a randomized controlled trial

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Maggie Laidlaw ◽  
Carla Ann Cockerline ◽  
Anthony L. Almada
2021 ◽  
Author(s):  
Remi Yoshikata ◽  
Khin Zay Yar Myint ◽  
Hiroaki Ohta ◽  
Yoko Ishigaki

Abstract Introduction: Equol, an isoflavone derivative whose chemical structure is similar to estrogen, is considered as a potentially effective agent for relieving climacteric symptoms, for the prevention of the lifestyle-related diseases, and for aging care in post-menopausal women. We investigated the effect of an equol-containing supplement on metabolism and aging, and climacteric symptoms, with respect to internally-produced equol in post-menopausal women.Methods: A single center, randomized controlled trial (registration number: UMIN000030975) on 57 post-menopausal Japanese women (mean age: 56±5.37 years), was conducted. Twenty-seven women received the equol supplement, while the remaining received Control. Metabolic and aging-related biomarkers were compared before and after the 3-month intervention. Climacteric symptoms were assessed every month using a validated self-administered questionnaire in Japanese post-menopausal women. Results: Three months post intervention, the treatment group showed significant improvement in climacteric symptoms, when compared to the Control group (81% vs. 53% respectively, p=0.045). We did not observe any beneficial effect on metabolic and aging-related biomarkers in the intervention group. However, in certain populations significant improvement in skin auto-fluorescence, which is a measurement of AGE skin products, and visceral fat area was observed, especially among equol producers. Conclusion: Women receiving equol supplement showed improved climacteric symptoms. This study offered a new hypothesis that there may be a synergy between supplemented equol and endogenously-produced equol to improve skin aging and visceral fat in certain populations.


2013 ◽  
Vol 227 (1) ◽  
pp. 140-146 ◽  
Author(s):  
Yuen-Fung Yiu ◽  
Kai-Hang Yiu ◽  
Chung-Wah Siu ◽  
Yap-Hang Chan ◽  
Sheung-Wai Li ◽  
...  

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Miriam K. Gustafsson ◽  
Pål R. Romundstad ◽  
Signe Nilssen Stafne ◽  
Anne-Sofie Helvik ◽  
Astrid Kamilla Stunes ◽  
...  

2019 ◽  
Vol 59 (2) ◽  
pp. 741-753 ◽  
Author(s):  
Ida M. Grønborg ◽  
Inge Tetens ◽  
Tue Christensen ◽  
Elisabeth W. Andersen ◽  
Jette Jakobsen ◽  
...  

2014 ◽  
Vol 19 (6) ◽  
pp. 485-492 ◽  
Author(s):  
P. Bernard ◽  
G. Ninot ◽  
P.L. Bernard ◽  
M.C. Picot ◽  
A. Jaussent ◽  
...  

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