scholarly journals Effects of age and chronic alcohol self‐administration on plasma mineralocorticoid and glucocorticoid concentrations in male rhesus monkeys

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Christa M Helms ◽  
Kathleen A Grant
Keyword(s):  
Rhesus Monkeys ◽  
Chronic Alcohol ◽  
Self Administration ◽  
Male Rhesus

scholarly journals Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys

2020 ◽  
Vol 237 (5) ◽  
pp. 1471-1480 ◽  
Author(s):  
C. Austin Zamarripa ◽  
Jennifer E. Naylor ◽  
Sally L. Huskinson ◽  
E. Andrew Townsend ◽  
Thomas E. Prisinzano ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Self Administration ◽  
Kappa Opioid ◽  
Opioid Agonists ◽  
Male Rhesus

scholarly journals Extinguishing cocaine-associated discriminative stimuli attenuates cocaine vs food choice in male rhesus monkeys

2019 ◽  
Author(s):  
Matthew L Banks ◽  
Blake A. Hutsell ◽  
S Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Fixed Ratio ◽  
Concurrent Schedule ◽  
Food Delivery ◽  
Self Administration ◽  
Discriminative Stimuli ◽  
Choice Procedure ◽  
Choice Procedures ◽  
Male Rhesus

ABSTRACTBackgroundIn drug addiction, relapse can be triggered by cues that function as discriminative stimuli to signal contingencies of drug availability and promote drug-taking behavior. Extinction procedures can weaken the association between drug-associated cues and drug use and may reduce the probability of relapse. This study evaluated effects of a regimen of extinction training on cocaine self-administration maintained in rhesus monkeys under a cocaine-vs.-food choice procedure that has been used previously to evaluate effectiveness of other candidate treatments for cocaine abuse.MethodsBehavior was initially maintained under a concurrent schedule of food delivery (1-g food pellets; fixed-ratio 100 schedule) and cocaine injections (0-0.1 mg/kg/injection; fixed-ratio 10 schedule) during daily 2-h choice sessions in male rhesus monkeys (n=4). Subsequently, choice sessions were supplemented by daily 20-h extinction sessions for 14 consecutive days. During extinction sessions, cocaine-associated discriminative stimuli were presented, but responding did not produce cocaine injections. Cocaine continued to be available during choice sessions.ResultsPrior to extinction, cocaine maintained a dose-dependent increase in cocaine vs. food choice. Responding during extinction sessions declined to low levels by the fifth day. Exposure to extinction sessions produced a more gradual but significant decline in cocaine choice and a complementary increase in food choice during choice sessions.ConclusionsThese preclinical results support the effectiveness of extinguishing cocaine-associated discriminative stimuli as a non-pharmacological treatment strategy for reducing cocaine choice. Moreover, these results also support the construct validity of preclinical drug vs. food choice procedures as a tool for candidate treatment evaluation for cocaine addiction.

Evaluation of hippocampus in rhesus monkeys after chronic (1-year) inhalation exposure to marijuana: I. Electron microscopy

1990 ◽  
Vol 48 (3) ◽  
pp. 398-399
Author(s):  
A.M. Andrews ◽  
S.W. Wilson ◽  
A.C. Scallet ◽  
S.F. Ali ◽  
J. Bailey ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Rhesus Monkeys ◽  
Low Dose ◽  
Inhalation Exposure ◽  
Synaptic Cleft ◽  
High Dose ◽  
Withdrawal Time ◽  
Treatment Groups ◽  
Ultrastructural Evidence ◽  
Male Rhesus

Exposure of rhesus monkeys (Macaca mulatta) to marijuana via inhalation or to intravenous delta-9-tetrahydrocannabinol (THC), reportedly caused ultrastructural evidence of increased synaptic width. Chronic marijuana smoke in a single rhesus monkey examined after a six month withdrawal time caused ultrastructure changes in the septal, hippocampal and amygdala regions; the synaptic cleft was widened, electron opaque material was found in the cleft and in the pre- and postsynaptic regions, with some clumping of the synaptic vesicles. The objective of our study was to assess neuropathological alterations produced by chronic inhalation of marijuana smoke.Nineteen male rhesus monkeys, 3-5 years of age and weighing 3-8 kg, were divided into four treatment groups: a) sham control, b) placebo smoke (7 days/ week) c) low dose marijuana (2 times/week with 5 days/week sham) and d) high dose marijuana (7 times/week). A smoke exposure consisted of smoke from one cigarette (2.6% THC) burned down to 10 mm butt length. Smoke was administered via smoke generator (ADL II, Arthur D. Little, Inc. Cambridge, MA) and nose-mouth only masks (local production) equipped with one-way valves.

scholarly journals The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys

2010 ◽  
Vol 213 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Christopher A. Podlesnik ◽  
Mei-Chuan Ko ◽  
Gail Winger ◽  
Jürgen Wichmann ◽  
Eric P. Prinssen ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Receptor Agonist ◽  
Orphanin Fq ◽  
Self Administration

Experimental delayed radiation necrosis of the brain

1979 ◽  
Vol 51 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Albert N. Martins ◽  
Ralph E. Severance ◽  
James M. Henry ◽  
Thomas F. Doyle
Keyword(s):  
Rhesus Monkeys ◽  
Radiation Necrosis ◽  
Clinical Signs ◽  
Control Group ◽  
Content Type ◽  
Brain Irradiation ◽  
Primate Brain ◽  
High Doses ◽  
The Brain ◽  
Male Rhesus

✓ The authors have designed an experiment to detect a hitherto unrecognized interaction between high doses of the glucocorticoid, dexamethasone, and brain irradiation. Eighteen juvenile male rhesus monkeys received 1800 rads to the whole brain in 8.5 minutes. For 1½ days before and 10½ days after the irradiation, nine animals received approximately 2.9 mg/kg/day of dexamethasone intramuscularly in addition to irradiation, while the remaining nine animals served as the control group and received saline. All animals eventually developed a progressive neurological syndrome, and died of delayed radiation necrosis of the brain. The two groups were compared with regard to latency to onset of clinical signs, survival time, and number, distribution, and location of lesions of radionecrosis. Large doses of dexamethasone did not alter the susceptibility of the primate brain to delayed radiation necrosis. Detailed morphological study of the radionecrotic lesions supports the hypothesis that most, if not all, of the lesions develop as the consequence of injury to blood vessels.

scholarly journals Withdrawal from long-term methamphetamine self-administration ‘normalizes’ neurometabolites in rhesus monkeys: a1H MR spectroscopy study

2013 ◽  
Vol 20 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Shaolin Yang ◽  
Annabelle M. Belcher ◽  
Svetlana Chefer ◽  
D. Bruce Vaupel ◽  
Charles W. Schindler ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Rhesus Monkeys ◽  
Spectroscopy Study ◽  
Self Administration
Sign in / Sign up

Export Citation Format

Share Document