scholarly journals The Reduction Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1) on Postprandial Blood Glucose Levels in Healthy Individuals

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Yu‐Ri Kang ◽  
Sung‐Hoon Jo ◽  
Se‐Woon Lee ◽  
Seong‐Cheol Kim ◽  
Emmanouil Apostolidis ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Low Molecular Weight ◽  
Chitosan Oligosaccharide ◽  
Healthy Individuals ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Low Molecular Weight Chitosan ◽  
Reduction Effect

scholarly journals Chitosan oligosaccharide (GO2KA1) improves postprandial glycemic response in subjects with impaired glucose tolerance and impaired fasting glucose and in healthy subjects: a crossover, randomized controlled trial

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sarang Jeong ◽  
Jung Min Cho ◽  
Young-In Kwon ◽  
Seong-Chul Kim ◽  
Dong Yeob Shin ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Healthy Subjects ◽  
Fasting Glucose ◽  
Test Group ◽  
Postprandial Blood Glucose ◽  
Chitosan Oligosaccharide ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Background The antidiabetic and hypoglycemic effects of chitosan have been reported in previous studies. We have previously shown that chitosan oligosaccharide reduces postprandial blood glucose levels in vivo. We conducted a short-term crossover study to support the results of the previous study. Methods The study was a randomized, double-blind, controlled crossover trial completed at one clinical research site. Subjects with impaired glucose tolerance and impaired fasting glucose and healthy subjects were randomly assigned to consume one of two different experimental test capsules that differed in only the sample source (GO2KA1 vs placebo), and all subjects were instructed to consume the 75 g sucrose within 15 min. After a 7-day interval, the subjects consumed the other capsules that were not consumed on the first day. We assessed blood glucose levels using a 2-h oral sucrose tolerance test. The study was registered at clinicaltrials.gov (NCT03650023). Results The test group showed significantly lower blood glucose levels at 60 min (p = 0.010) and postprandial blood glucose areas under the curve (p = 0.012). The change in blood glucose levels at 60 min was significantly lower in the test group than in the placebo group (p = 0.017). Conclusions Based on the results of this study, the consumption of chitosan oligosaccharide (GO2KA1) supplements with a meal can effectively reduce postprandial blood glucose levels, which is relevant to the prevention of diabetes.

scholarly journals Black tea decreases postprandial blood glucose levels in healthy humans and contains high-molecular-weight polyphenols that inhibit α-glucosidase and α-amylase in vitro: a randomized, double blind, placebo-controlled, crossover trial

2021 ◽  
Vol 11 (5) ◽  
pp. 222
Author(s):  
Yoshikazu Isono ◽  
Hisako Watanabe ◽  
Masafumi Kumada ◽  
Tsuyoshi Takara ◽  
Shin-ichiro Iio
Keyword(s):  
Molecular Weight ◽  
Blood Glucose ◽  
High Molecular Weight ◽  
Area Under The Curve ◽  
Black Tea ◽  
Postprandial Blood Glucose ◽  
Double Blind ◽  
Glucose Levels ◽  
Healthy Humans ◽  
Blood Glucose Levels

Background: To prevent diabetes, it is important to control postprandial glycemic levels. Studies have suggested that consuming black tea decreases the risk of type 2 diabetes; however, only a few studies have examined the effects of black tea on postprandial glycemic control after consuming starch-rich foods. In addition, the mechanism underlying the suppression of postprandial glucose levels remains unclear.Objective: To investigate the effects of black tea on postprandial blood glucose levels in healthy humans and to identify the components of black tea that inhibit digestive enzymes.Methods: The inhibitory activity of black tea on digestive enzymes was measured, and the inhibitory components were fractionated. Healthy Japanese adults ingested 200 ml of black tea, and its effect on postprandial blood glucose and insulin levels were investigated. Results: Black tea dose-dependently inhibited α-glucosidase, sucrase, and α-amylase activity. The major components responsible for this inhibition were high–molecular-weight polyphenols. The galloyl moieties present in these compounds play an important role in their inhibitory activities. Two randomized, double-blind, placebo-controlled, crossover studies of healthy human subjects (total n = 46) were conducted to investigate the effect of black tea on blood glucose and insulin levels. Combined data from the two studies showed that black tea ingestion (200 mL) after cooked rice intake (200 g) significantly reduced the incremental area under the curve of glucose (P =.024) and insulin (P =.014) compared to placebo drink.Conclusions: The high–molecular-weight polyphenols in black tea inhibited α-glucosidase, sucrase, and α-amylase activity in a dose-dependent manner. Furthermore, black tea ingestion after eating cooked rice significantly reduced the incremental area under the curve of glucose and insulin. These effects of black tea could be attributed to the inhibition of digestive enzymes by high–molecular-weight polyphenols containing galloyl groups.Keywords: black tea, blood glucose, α-glucosidase, α-amylase, polyphenol

scholarly journals Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models

2016 ◽  
Vol 52 (4) ◽  
pp. 761-769 ◽  
Author(s):  
Any de Castro Ruiz Marques ◽  
Fabiana Percinoto Monteiro Schiavon ◽  
Patricia Batista Travassos ◽  
Vanessa Fontana Eik ◽  
Guilherme Godoy ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Clinical Models ◽  
The Impact

scholarly journals Effects of Various Blending Ratios of Rice and Waxy Barley on Postprandial Blood Glucose Levels

2018 ◽  
Vol 71 (6) ◽  
pp. 283-288
Author(s):  
Seiichiro Aoe ◽  
Kozo Komae ◽  
Yutaka Inoue ◽  
Isamu Murata ◽  
Yuki Minegishi ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels
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