scholarly journals Delivery of a TNF‐α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell‐cycle arrest and caspase‐dependent apoptosis

2018 ◽  
Vol 32 (12) ◽  
pp. 6948-6964 ◽  
Author(s):  
Qiuxia Yan ◽  
Xueming Chen ◽  
Huizhen Gong ◽  
Pei Qiu ◽  
Xing Xiao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Tnf Α

HL-60 Cell Death Induced by Lycorine Is Due to p21-Mediated Cell Cycle Arrest and TNF-α Signaling Stimulation.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4158-4158
Author(s):  
Jing Liu ◽  
Ji-liang Hu ◽  
Yang He ◽  
Bi-Wei Shi ◽  
Wei-Xin Hu
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Conflicts Of Interest ◽  
Rt Pcr ◽  
Cycle Arrest ◽  
Tnf Α ◽  
Induced Apoptosis ◽  
Related Proteins ◽  
Human Acute Promyelocytic Leukemia ◽  
Differential Genes

Abstract Abstract 4158 Lycorine displays various biological functions including remarkable anti-tumor effect. We previously reported that lycorine induced anti-leukemia effect via arresting cell cycle and inducing apoptosis on human acute promyelocytic leukemia (APL) cell line HL-60. To explore the molecular mechanism how lycorine induced HL-60 cell apoptosis, cDNA microarray was used to investigate the expression profile of 494 apoptosis-associated genes. Real-time RT-PCR, Western blotting and immunocytochemistry were used to analyze the expression of related genes, as well as the modification and distribution of related proteins in the presence of lycorine. The results showed that 89 differential genes were expressed significantly (Cy3:Cy5 > 2 or < 0.5) among all the 494 apoptosis-related genes. 78 genes were up-regulated and 11 genes were down-regulated. We are particularly interested in the expression increase of p21 (9.271 folds) and TNF-α (8.242 folds). Furthermore, we found that lycorine could down-regulate p21-related gene expression including Cdc2, Cyclin B, Cdk2 and Cyclin E, promote the truncation of Bid protein and the release of cytochrome c from mitochondria, decrease the phosphorylation of IκB, block the nuclear import of NF-κB and down-regulate expression of survivin. This study revealed that lycorine decreased HL-60 cells survival through p21-mediated cell cycle arrest and stimulation of TNF-α signaling pathway which induced apoptosis. Disclosures: No relevant conflicts of interest to declare.

Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-α plus IFN-γ on polystyrene and the role of p53 activation

Biomaterials ◽  
2012 ◽  
Vol 33 (26) ◽  
pp. 6162-6171 ◽  
Author(s):  
Yan-Qing Guan ◽  
Zhibin Li ◽  
Aini Yang ◽  
Zheng Huang ◽  
Zhe Zheng ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Tnf Α ◽  
P53 Activation ◽  
Ifn Γ ◽  
Mcf 7

scholarly journals Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNF-α

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176965 ◽  
Author(s):  
Gao Chao ◽  
Xiaoning Tian ◽  
Wentao Zhang ◽  
Xuehai Ou ◽  
Fei Cong ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Tnf Α

Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest

2014 ◽  
Vol 83 ◽  
pp. 155-166 ◽  
Author(s):  
Mohamed Fares ◽  
Sahar Mahmoud Abou-Seri ◽  
Hatem A. Abdel-Aziz ◽  
Safinaz E.-S. Abbas ◽  
Mohieldin Magdy Youssef ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Pyrimidine Derivatives ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

Abstract PD8-04: Antitumor activity of Z-endoxifen (ENDX) is mediated via PKCβ1-dependent ERα loss and cell cycle arrest in ERα-positive breast cancer

2021 ◽  
Author(s):  
Swaathi Jayaraman ◽  
Mary J Kuffel ◽  
Krishna R Kalari ◽  
Kevin J Thompson ◽  
Xiaojia Tang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
Positive Breast Cancer

scholarly journals Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells

2018 ◽  
Vol 81 (8) ◽  
pp. 1701-1710 ◽  
Author(s):  
Chun-Yan Zhang ◽  
Li-Jun Zhang ◽  
Zhi-Cheng Lu ◽  
Chen-Yun Ma ◽  
Ying Ye ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Cycle Arrest ◽  
Jatropha Gossypiifolia

Cell cycle arrest and antitumor activity of pironetin and its derivatives

1998 ◽  
Vol 126 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Masuo Kondoh ◽  
Takeo Usui ◽  
Shinichi Kobayashi ◽  
Kouichi Tsuchiya ◽  
Kiyohiro Nishikawa ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Cell Cycle Arrest ◽  
Cycle Arrest
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