Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in
            hsa‐mir‐23a‐5p
            ,
            ‐193a‐5p
            , and
            ‐193b‐5p
            and insulin‐like growth factor 2 expression

Abstract BackgroundWe aimed to explore the relationship between serum fibroblast growth factor 19 (FGF19) and the atherogenic index of plasma (AIP) in type 2 diabetic patients.MethodsSerum FGF19 levels and lipid profiles were measured in 200 patients with type 2 diabetes (T2D). The levels of serum FGF19 were measured by ELISA. Lipid profiles were measured by enzymatic analysis. AIP and NAFLD fibrosis scores were calculated.ResultsT2D patients showed a significant decreasing trend of FGF19 concentrations depending on the tertiles of AIP (p for trend < 0.05). Simultaneously, the AIP level was closely related to the serum FGF19 level (p < 0.05). Furthermore, after adjusting for age, sex, duration, BMI, hypertension, and diabetic treatment, the correlation was still significant (p < 0.01), and it remained significant even after further adjusting for non-alcoholic fatty liver disease (NAFLD) and NAFLD fibrosis score (NFS) (p < 0.01). However, when stratified by BMI, AIP was positively correlated with FGF19 in normal-weight and overweight T2D patients but not in obese T2D subjects. After adjusting for sex, age, BMI, duration, hypertension, HbA1c, 2hPG, HOMA-IR, AIP, antidiabetic treatments, NAFLD and NFS via multiple stepwise linear regression, AIP was an independent factor affecting serum FGF19 concentrations (SE = 0.238, β = -0.290, p < 0.01).ConclusionsSerum FGF19 levels might be a good predictor for atherosclerosis and cardiovascular disease in T2D patients, especially among non-obese patients; serum FGF19 levels were significantly inversely associated with AIP.

Download Full-text

Circulating Chemerin Levels are Increased in First-Degree Relatives of Type 2 Diabetic Patients

Clinical Laboratory ◽

10.7754/clin.lab.2013.130503 ◽

2014 ◽

Vol 60 (06/2014) ◽

Cited By ~ 2

Author(s):

Xh. Zhuang ◽

Fd. Sun ◽

Sh. Chen ◽

Yt. Liu ◽

W. Liu ◽

...

Keyword(s):

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

First Degree Relatives ◽

Type 2 Diabetic

Download Full-text

Endothelial function and biochemical vascular markers in first-degree relatives of type 2 diabetic patients: the effect of exercise training

Metabolism ◽

10.1016/j.metabol.2006.06.024 ◽

2006 ◽

Vol 55 (11) ◽

pp. 1508-1515 ◽

Cited By ~ 27

Author(s):

Torben Østergård ◽

Birgit Nyholm ◽

Troels K. Hansen ◽

Lars M. Rasmussen ◽

Jørgen Ingerslev ◽

...

Keyword(s):

Exercise Training ◽

Endothelial Function ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

First Degree Relatives ◽

Vascular Markers ◽

Type 2 Diabetic

Download Full-text

Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00012.2005 ◽

2006 ◽

Vol 290 (5) ◽

pp. E998-E1005 ◽

Cited By ~ 56

Author(s):

Torben Østergård ◽

Jesper L. Andersen ◽

Birgit Nyholm ◽

Sten Lund ◽

K.Sreekumaran Nair ◽

...

Keyword(s):

Skeletal Muscle ◽

Insulin Sensitivity ◽

Exercise Training ◽

Oxidative Capacity ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Muscle Oxidative Capacity ◽

First Degree Relatives ◽

Type 2 Diabetic

First-degree relatives of type 2 diabetic patients (offspring) are often characterized by insulin resistance and reduced physical fitness (V̇o2 max). We determined the response of healthy first-degree relatives to a standardized 10-wk exercise program compared with an age-, sex-, and body mass index-matched control group. Improvements in V̇o2 max(14.1 ± 11.3 and 16.1 ± 14.2%; both P < 0.001) and insulin sensitivity (0.6 ± 1.4 and 1.0 ± 2.1 mg·kg−1·min−1; both P < 0.05) were comparable in offspring and control subjects. However, V̇o2 maxand insulin sensitivity in offspring were not related at baseline as in the controls ( r = 0.009, P = 0.96 vs. r = 0.67, P = 0.002). Likewise, in offspring, exercise-induced changes in V̇o2 maxdid not correlate with changes in insulin sensitivity as opposed to controls ( r = 0.06, P = 0.76 vs. r = 0.57, P = 0.01). Skeletal muscle oxidative capacity tended to be lower in offspring at baseline but improved equally in both offspring and controls in response to exercise training (Δcitrate synthase enzyme activity 26 vs. 20%, and Δcyclooxygenase enzyme activity 25 vs. 23%. Skeletal muscle fiber morphology and capillary density were comparable between groups at baseline and did not change significantly with exercise training. In conclusion, this study shows that first-degree relatives of type 2 diabetic patients respond normally to endurance exercise in terms of changes in V̇o2 maxand insulin sensitivity. However, the lack of a correlation between the V̇o2 maxand insulin sensitivity in the first-degree relatives of type 2 diabetic patients indicates that skeletal muscle adaptations are dissociated from the improvement in V̇o2 max. This could indicate that, in first-degree relatives, improvement of insulin sensitivity is dissociated from muscle mitochondrial functions.

Download Full-text