Positive and negative symptoms, depression and social disability in chronic schizophrenia

1992 ◽  
Vol 7 (2) ◽  
pp. 67-72 ◽  
Author(s):  
S. McLaren ◽  
J. C. Cookson ◽  
T. Silverstone
Keyword(s):  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Social Disability ◽  
Positive And Negative Symptoms

Three Syndromes in Chronic Schizophrenia

1989 ◽  
Vol 155 (S7) ◽  
pp. 119-122 ◽  
Author(s):  
P.F. Liddle ◽  
Thomas R.E. Barnes ◽  
D. Morris ◽  
S. Haque
Keyword(s):  
Cognitive Impairment ◽  
Clinical Features ◽  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Brain Abnormalities ◽  
Brain Abnormality ◽  
Schizophrenic Patients ◽  
Extensive Body ◽  
Positive And Negative Symptoms

In recent years, exploration of the distinction between positive and negative symptoms of schizophrenia has provided a fruitful basis for attempts to relate the clinical features of schizophrenia to the accumulating evidence of brain abnormalities in schizophrenic patients. By 1982, there was an extensive body of evidence supporting the hypothesis that negative schizophrenic symptoms, such as poverty of speech and flatness of affect, were associated with substantial brain abnormalities, such as increased ventricular to brain ratio, and extensive cognitive impairment (Crow, 1980; Andreasen & Olsen, 1982). However, at that stage there were several fundamental unanswered questions about the nature of negative symptoms, and their relationship to indices of brain abnormality. This paper presents some findings of a series of studies initiated in 1982 to seek answers to some of these questions.

Rumination, Depressive Symptoms and Awareness of Illness in Schizophrenia

2012 ◽  
Vol 42 (2) ◽  
pp. 143-155 ◽  
Author(s):  
Neil Thomas ◽  
Darryl Ribaux ◽  
Lisa J. Phillips
Keyword(s):  
Mental Illness ◽  
Depressive Symptoms ◽  
Cognitive Processes ◽  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Social Consequences ◽  
Stable Phase ◽  
Negative Thinking ◽  
The Social ◽  
Positive And Negative Symptoms

Background: Depressive symptoms are common in schizophrenia. Previous studies have observed that depressive symptoms are associated with both insight and negative appraisals of illness, suggesting that the way in which the person thinks about their illness may influence the occurrence of depressive responses. In affective disorders, one of the most well-established cognitive processes associated with depressive symptoms is rumination, a pattern of perseverative, self-focused negative thinking. Aims: This study examined whether rumination focused on mental illness was predictive of depressive symptoms during the subacute phase of schizophrenia. Method: Forty participants with a diagnosis of schizophrenia and in a stable phase of illness completed measures of rumination, depressive symptoms, awareness of illness, and positive and negative symptoms. Results: Depressive symptoms were correlated with rumination, including when controlling for positive and negative symptoms. The content of rumination frequently focused on mental illness and its causes and consequences, in particular social disability and disadvantage. Depressive symptoms were predicted by awareness of the social consequences of mental illness, an effect that was mediated by rumination. Conclusions: Results suggest that a process of perseveratively dwelling upon mental illness and its social consequences may be a factor contributing to depressive symptoms in people with chronic schizophrenia.

Positive and negative symptoms in chronic schizophrenia: A 1-year follow-up study

1990 ◽  
Vol 3 (1) ◽  
pp. 72
Author(s):  
C.L. Cazzullo ◽  
P Boato ◽  
E Gianpieri ◽  
G.M. Gidobio ◽  
G Invernizzi ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Follow Up Study ◽  
Positive And Negative Symptoms

scholarly journals Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lucy D. Vanes ◽  
Elias Mouchlianitis ◽  
Krisna Patel ◽  
Erica Barry ◽  
Katie Wong ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Symptom Severity ◽  
Negative Symptoms ◽  
Neural Circuits ◽  
Chronic Schizophrenia ◽  
Early Psychosis ◽  
Positive Symptoms ◽  
Precentral Gyrus ◽  
Initial Development ◽  
Positive And Negative Symptoms

Abstract Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop task and its relationship with positive and negative symptoms in early psychosis (EP, N = 88) and chronic schizophrenia (CHR-SZ, N = 38) patients. CHR-SZ patients showed reduced frontal, striatal, and parietal activation across incongruent and congruent trials compared to EP patients. Higher positive symptom severity was associated with reduced activation across both trial types in supplementary motor area (SMA), middle temporal gyrus and cerebellum in EP, but not CHR-SZ patients. Higher negative symptom severity was associated with reduced cerebellar activation in EP, but not in CHR-SZ patients. A negative correlation between negative symptoms and activation in SMA and precentral gyrus was observed in EP patients and in CHR-SZ patients. The results suggest that the neural substrate of positive symptoms changes with illness chronicity, and that cognitive control related neural circuits may be most relevant in the initial development phase of positive symptoms. These findings also highlight a changing role for the cerebellum in the development and later maintenance of both positive and negative symptoms.

The Effect of Propranolol and Thioridazine on Positive and Negative Symptoms of Schizophrenia

1985 ◽  
Vol 147 (6) ◽  
pp. 623-630 ◽  
Author(s):  
D. Eccleston ◽  
A. F. Fairbairn ◽  
F. Hassanyeh ◽  
H. A. McClelland ◽  
D. A. Stephens
Keyword(s):  
Negative Symptoms ◽  
Chronic Schizophrenia ◽  
Blind Study ◽  
Double Blind Study ◽  
Type I ◽  
Type Ii ◽  
Double Blind ◽  
Positive Type ◽  
Negative Type ◽  
Positive And Negative Symptoms

Patients with chronic schizophrenia were treated with either propranolol (640 mg daily) or thioridazine (400 mg daily). In a double-blind study lasting five weeks, propranolol was superior to thioridazine on both psychiatrists' and nurses' ratings. Significant improvements were noted with propranolol in both positive (Type I) and negative (Type II) symptoms.

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