FIXED VERY-LOW-DOSE COMBINATION PERINDOPRIL 2 mg/INDAPAMIDE 0.625 mg IN THE TREATMENT OF ESSENTIAL ARTERIAL HYPERTENSION IN VERY ELDERLY PATIENTS (±75 YEARS)

The paper gives the data of the authors’ trial of the effect of the fixed-dose combination antihypertensive drug lisinopril + amlodipine on blood pressure level and cognitive functions in 25 elderly patients with grades 1–2 arterial hypertension. The test drug has a high antihypertensive efficacy, as shown by both routine blood pressure measurements and 24-hour monitoring data. The findings suggest that the fixed-dose combination antihypertensive drug lisinopril + amlodipine improves a number of parameters characterizing cognitive functions

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Arterial hypertension in the elderly and higher mental functions. Possibilities of an-tihypertensive therapy withArifon retard in the prevention of dementia.

Systemic Hypertension ◽

10.26442/sg33102 ◽

2009 ◽

Vol 6 (4) ◽

pp. 63-66

Author(s):

Ol'ga Dmitrievna Ostroumova ◽

Natal'ya Konstantinovna Korsakova ◽

Natal'ya Aleksandrovna Varako

Keyword(s):

Elderly Patients ◽

Arterial Hypertension ◽

Low Dose ◽

Disease Duration ◽

The Elderly ◽

Once Daily ◽

Mental Functions ◽

Higher Mental Functions ◽

Neuropsychological Study

Low-dose thiazide and thiazide-like diuretics (indapamide retard) are the drugs of choice in the treatment of elderly patients with arterial hypertension (AH), including isolated systolic AH (ISAH). The problem of treatment of AH in elderly patients is associated with that of vascular dementia. Despite the fact that AH is a major risk factor in the development and progression of dementia, its impact on higher mental functions in patients, including geriatric ones, has been little studied to the present day. The paper also gives the results of Syst-Eur and HYVET clinical trials. The results of the authors\' investigation are also presented. Twenty-six elderly patients (aged 60-74 years; mean age 65.2+5.9 years) with untreated or ineffectively treated grades 1-2 essential AH (mean disease duration 17.3+5.6 years) were examined; women were 84.6%; patients with ISAH and those with grade 1 AH were 70,8 and 84.6%, respectively. The patients were given the diuretic indapamide retard (Arifon retard, (Servier, France) in a dose of 1.5 once daily in the morning; the follow-up was 24 weeks. Physical examination, routine blood pressure (BP), 24-hour BP monitoring, and neuropsychological study, as described by A.R. Lu-ria, were conducted. Following 24-week treatment, there was a significant reduction in both di-urnal and nocturnal systolic and diastolic BP. After the performed treatment, there was a signifi-cant visual-logistic improvement (p

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Selection of antihypertensive therapy in elderly patients, combination therapy: thiazide-like diuretics and calcium channel blockers

Russian Journal of Cardiology ◽

10.15829/1560-4071-2018-11-117-122 ◽

2018 ◽

pp. 117-122

Author(s):

Z. M. Galeyeva ◽

A. S. Galyavich ◽

L. V. Baleyeva ◽

E. G. Safina ◽

O. V. Sorokina

Keyword(s):

Combination Therapy ◽

Elderly Patients ◽

Arterial Hypertension ◽

Antihypertensive Therapy ◽

Calcium Channel Blockers ◽

Fixed Dose ◽

Channel Blockers ◽

Dose Combination ◽

Positive Effect ◽

Selection Of

The article presents data about the prevalence and expected prognosis for arterial hypertension. Emphasis is placed on the selection of antihypertensive therapy in elderly patients. The features concerning the positive effect of the calcium channelblocking agent — amlodipine, thiazidlike diuretic — indapamide retard in the form of monotherapy and a combination of the above drugs on the course and prognosis of arterial hypertension in elderly patients are investigated. A clinical example of the use of the fixed dose combination amlodipine + indapamide retard is also introduced.

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