Multiple primary brain tumors of different cell types

Neurosurgery ◽  
1981 ◽  
Vol 8 (1) ◽  
pp. 20???5 ◽  
Author(s):  
H G Deen ◽  
E R Laws
Keyword(s):  
Brain Tumors ◽  
Cell Types ◽  
Primary Brain Tumors ◽  
Multiple Primary ◽  
Different Cell Types

Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child

2010 ◽  
Vol 5 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Andrew Jea ◽  
Ernesto Coscarella ◽  
Murali Chintagumpala ◽  
Meena Bhattacharjee ◽  
William E. Whitehead ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Mr Imaging ◽  
Pilocytic Astrocytoma ◽  
Cell Types ◽  
Cerebellar Hemisphere ◽  
Pathological Examination ◽  
Primary Brain Tumors ◽  
Juvenile Pilocytic Astrocytoma ◽  
Multiple Primary ◽  
Different Cell Types

Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature. However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare. Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types. The authors describe the case of an 8-year-old boy who presented with a 2-week history of progressive headache, nausea and vomiting, and imbalance. Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis. Spinal MR imaging was unremarkable. The patient underwent a suboccipital craniotomy and subsequent gross-total resection of both mass lesions. Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively. The patient did well in the immediate postoperative period, was discharged home, and underwent neurooncological follow-up. To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors. They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.

Multiple Primary Brain Tumors of Different Cell Types

Neurosurgery ◽  
1981 ◽  
Vol 8 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Gordon H. Deen ◽  
Edward R. Laws
Keyword(s):  
Brain Tumors ◽  
Clinical Significance ◽  
Mayo Clinic ◽  
Clinical Presentation ◽  
Cell Types ◽  
Multiple Tumors ◽  
Primary Brain Tumors ◽  
Histological Types ◽  
Multiple Primary ◽  
Different Cell Types

Abstract Eighteen cases of multiple primary brain tumors of different histological types were found in a review of Mayo Clinic records from 1950 to 1978. The predisposing factors, clinical presentation, location, and type of tumor are discussed. The clinical significance and etiology of these multiple tumors are considered.

scholarly journals Multiple Primary Brain Tumors of Different Histological Types

1991 ◽  
Vol 31 (3) ◽  
pp. 141-145 ◽  
Author(s):  
Takayuki TOKUNAGA ◽  
Minoru SHIGEMORI ◽  
Masaru HIROHATA ◽  
Yasuo SUGITA ◽  
Jun MIYAGI ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Primary Brain Tumors ◽  
Histological Types ◽  
Multiple Primary

scholarly journals The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors

2020 ◽  
Vol 21 (8) ◽  
pp. 2863 ◽  
Author(s):  
Maria L. Perepechaeva ◽  
Alevtina Y. Grishanova
Keyword(s):  
Brain Tumors ◽  
Aryl Hydrocarbon Receptor ◽  
Therapeutic Target ◽  
Current Knowledge ◽  
Cell Types ◽  
Pathological Process ◽  
Aryl Hydrocarbon ◽  
Oncogenic Protein ◽  
Different Cell Types

Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different cell types and contexts. Lately, there is growing evidence that aryl hydrocarbon receptor (AhR) plays an important part in the development of brain tumors. The role of AhR in brain tumors is complicated, depending on the type of tumor, on ligands that activate AhR, and other features of the pathological process. In this review, we summarize current knowledge about AhR in relation to brain tumors and provide an overview of AhR’s potential as a therapeutic target.

scholarly journals Multiple, Primary Brain Tumors with Diverse Origins and Different Localizations: Case Series and Review of the Literature

2018 ◽  
Vol 09 (04) ◽  
pp. 593-607
Author(s):  
Thara Tunthanathip ◽  
Kanet Kanjanapradit ◽  
Sanguansin Ratanalert ◽  
Nakornchai Phuenpathom ◽  
Thakul Oearsakul ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Case Series ◽  
Review Of The Literature ◽  
Poor Prognostic Factor ◽  
Literature Research ◽  
Primary Brain Tumors ◽  
Multiple Primary ◽  
Major Treatment ◽  
Low Incidence ◽  
Standard Practices

ABSTRACT Background: Multiple, primary brain tumors with different histological types occurring in the same patient are extremely rare. Several hypotheses have been proposed, and the pathophysiology of coexisting tumors has long been debated; however, due to low incidence, standard practices for this scenario are still inconclusive. Case Description: The authors describe 6 cases of coexisting tumors. By conducting a literature research focused on the computed tomography (CT) era and patients without prior radiation or phakomatosis. Sixty-five such reported cases were identified. In addition, the authors summarize their experience in 6 patients including histopathological features, chronological presentations, outcomes, mortality, and management from their series as well as from previous cases from the reported literature. Conclusion: The coexistence of multiple, primary brain tumors is an interesting condition. Surgical management remains the major treatment; malignant histology has a poor prognostic factor.

scholarly journals Multiple Primary Intracranial Tumors of Different Cell Types

1986 ◽  
Vol 26 (8) ◽  
pp. 639-643 ◽  
Author(s):  
Shoichiro KAWAGUCHI ◽  
Hideyuki OHNISHI ◽  
Takashi YUASA ◽  
Hiroyuki HASHIMOTO ◽  
Ken-ichiro HIRAMATSU
Keyword(s):  
Cell Types ◽  
Intracranial Tumors ◽  
Multiple Primary ◽  
Different Cell Types

Neurofibromatosis type 2 with multiple primary brain tumors in monozygotic twins

1999 ◽  
Vol 51 (5) ◽  
pp. 528-535 ◽  
Author(s):  
Hironobu Harada ◽  
Yoshiaki Kumon ◽  
Nobuaki Hatta ◽  
Saburo Sakaki ◽  
Shinsuke Ohta
Keyword(s):  
Brain Tumors ◽  
Monozygotic Twins ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Primary Brain Tumors ◽  
Multiple Primary

Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors

2004 ◽  
Vol 100 (4) ◽  
pp. 700-705 ◽  
Author(s):  
Peter Kan ◽  
Oren Gottfried ◽  
Deborah T. Blumenthal ◽  
Jeannette J. Townsend ◽  
Ela Drozd-Borysiuk ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Pilocytic Astrocytoma ◽  
Mass Effect ◽  
Low Grade ◽  
Content Type ◽  
Primary Brain Tumors ◽  
Juvenile Pilocytic Astrocytoma ◽  
Multiple Primary ◽  
Histological Characteristics ◽  
Fine Print

✓ Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type are well described in the literature. The concurrent presence of multiple primary brain tumors with different histological characteristics, however, is very rare. The authors describe the first known case in which an oligodendroglioma and a juvenile pilocytic astrocytoma (JPA) presented as synchronous primary brain tumors in the same patient. This 43-year-old man presented with a 2-month history of progressive headaches, nausea, and vomiting. Magnetic resonance imaging demonstrated an enhancing heterogeneous right medial cerebellar lesion and a larger calcified, nonenhancing, heterogeneous right frontal lesion with surrounding edema and a mass effect. The results of a metastatic workup were unremarkable. The patient underwent an initial right frontotemporal craniotomy and a subsequent suboccipital craniectomy 2 years later for resection of the posterior fossa lesion. Histological examination revealed the frontal and cerebellar lesions to be an oligodendroglioma and JPA, respectively. A molecular analysis detected a deletion of chromosome 1p36 in the oligodendroglioma, but not in the JPA. After the initial operation, the patient received follow-up care for his oligodendroglioma, but eventually required temozolomide for tumor progression. His condition remains stable both neurologically and according to imaging studies. The authors describe the first known case in which a low-grade oligodendroglioma and a JPA presented as synchronous primary brain tumors. They review the literature on multiple primary brain tumors with different histological characteristics and discuss potential mechanisms for the development of these lesions.

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