Multiple Primary Brain Tumors of Different Cell Types

Neurosurgery ◽  
1981 ◽  
Vol 8 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Gordon H. Deen ◽  
Edward R. Laws
Keyword(s):  
Brain Tumors ◽  
Clinical Significance ◽  
Mayo Clinic ◽  
Clinical Presentation ◽  
Cell Types ◽  
Multiple Tumors ◽  
Primary Brain Tumors ◽  
Histological Types ◽  
Multiple Primary ◽  
Different Cell Types

Abstract Eighteen cases of multiple primary brain tumors of different histological types were found in a review of Mayo Clinic records from 1950 to 1978. The predisposing factors, clinical presentation, location, and type of tumor are discussed. The clinical significance and etiology of these multiple tumors are considered.

Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child

2010 ◽  
Vol 5 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Andrew Jea ◽  
Ernesto Coscarella ◽  
Murali Chintagumpala ◽  
Meena Bhattacharjee ◽  
William E. Whitehead ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Mr Imaging ◽  
Pilocytic Astrocytoma ◽  
Cell Types ◽  
Cerebellar Hemisphere ◽  
Pathological Examination ◽  
Primary Brain Tumors ◽  
Juvenile Pilocytic Astrocytoma ◽  
Multiple Primary ◽  
Different Cell Types

Multiple metastatic brain tumors and multifocal primary brain tumors of a single histological type have been published in the adult and pediatric literature. However, the simultaneous occurrence of multiple primary brain tumors with different cell types is rare. Even more rare is the pediatric presentation of multiple primary brain tumors with different cell types. The authors describe the case of an 8-year-old boy who presented with a 2-week history of progressive headache, nausea and vomiting, and imbalance. Brain MR imaging demonstrated a heterogeneously enhancing mixed solid/cystic mass of the left cerebellar hemisphere and a larger, midline, more homogeneously enhancing lesion of the superior vermis. Spinal MR imaging was unremarkable. The patient underwent a suboccipital craniotomy and subsequent gross-total resection of both mass lesions. Pathological examination revealed the left cerebellar and superior vermian lesions to be a juvenile pilocytic astrocytoma and a medulloblastoma, respectively. The patient did well in the immediate postoperative period, was discharged home, and underwent neurooncological follow-up. To the best of the authors' knowledge, they describe the first known pediatric case in which a medulloblastoma and a juvenile pilocytic astrocytoma presented as synchronous primary brain tumors. They review the literature on multiple primary brain tumors with different histological characteristics and rehash potential mechanisms for their development.

scholarly journals Multiple Primary Brain Tumors of Different Histological Types

1991 ◽  
Vol 31 (3) ◽  
pp. 141-145 ◽  
Author(s):  
Takayuki TOKUNAGA ◽  
Minoru SHIGEMORI ◽  
Masaru HIROHATA ◽  
Yasuo SUGITA ◽  
Jun MIYAGI ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Primary Brain Tumors ◽  
Histological Types ◽  
Multiple Primary

Triple primary brain tumors of different histological types: Case report

1994 ◽  
Vol 41 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Shoichi Inagawa ◽  
Hiroyasu Yamakawa ◽  
Michio Nishikawa
Keyword(s):  
Case Report ◽  
Brain Tumors ◽  
Primary Brain Tumors ◽  
Histological Types

scholarly journals From first symptoms to diagnosis: Initial clinical presentation of primary brain tumors

2020 ◽  
Vol 4 (2) ◽  
pp. 2514183X2096836
Author(s):  
B Alther ◽  
V Mylius ◽  
M Weller ◽  
AR Gantenbein
Keyword(s):  
Brain Tumors ◽  
Clinical Presentation ◽  
Personality Change ◽  
University Hospital ◽  
World Health ◽  
Low Grade ◽  
High Grade ◽  
Primary Brain Tumors ◽  
Presenting Symptoms ◽  
Time To Diagnosis

Background: Despite modern imaging methods, a long symptom-to-diagnosis interval can be observed in patients with primary brain tumors. Objective: The study evaluated the initial and subsequent clinical presentation of patients with brain tumors in the context of time to diagnosis, localization, histology, and tumor grading. Methods: In this retrospective analysis of 85 consecutive patients with primary brain tumors, we assessed the presenting symptoms and signs. The analyses were based on entries from medical records at the Department of Neurology of Zurich University Hospital between 2005 and 2010. Results: A total of 54 men and 31 women with a mean age at diagnosis of 48 years were included. 60% of the patients present with a malignant tumor (World Health Organization grading III–IV), 24.7% with a benign tumor (I–II), and 15.3% were not classified. The interval between symptom onset and diagnosis varied from 1 day to 96 months (median: 39 days). High-grade tumors (III–IV) were diagnosed significantly earlier than low-grade tumors (II) after the first symptoms occurred (median: 26 vs. 138 days; z = −3.847, p < 0.001). Conclusions: Symptoms with a short symptom-to-diagnosis interval such as nausea/vomiting, seizures, as well as of personality change are assumed to contribute to a faster diagnosis in high-grade tumors. Visual disturbances and headaches, although occurring relatively seldom, did not contribute to a decrease in time to diagnosis and should therefore be considered for further diagnostic workup.

scholarly journals The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors

2020 ◽  
Vol 21 (8) ◽  
pp. 2863 ◽  
Author(s):  
Maria L. Perepechaeva ◽  
Alevtina Y. Grishanova
Keyword(s):  
Brain Tumors ◽  
Aryl Hydrocarbon Receptor ◽  
Therapeutic Target ◽  
Current Knowledge ◽  
Cell Types ◽  
Pathological Process ◽  
Aryl Hydrocarbon ◽  
Oncogenic Protein ◽  
Different Cell Types

Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different cell types and contexts. Lately, there is growing evidence that aryl hydrocarbon receptor (AhR) plays an important part in the development of brain tumors. The role of AhR in brain tumors is complicated, depending on the type of tumor, on ligands that activate AhR, and other features of the pathological process. In this review, we summarize current knowledge about AhR in relation to brain tumors and provide an overview of AhR’s potential as a therapeutic target.

scholarly journals Multiple, Primary Brain Tumors with Diverse Origins and Different Localizations: Case Series and Review of the Literature

2018 ◽  
Vol 09 (04) ◽  
pp. 593-607
Author(s):  
Thara Tunthanathip ◽  
Kanet Kanjanapradit ◽  
Sanguansin Ratanalert ◽  
Nakornchai Phuenpathom ◽  
Thakul Oearsakul ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Case Series ◽  
Review Of The Literature ◽  
Poor Prognostic Factor ◽  
Literature Research ◽  
Primary Brain Tumors ◽  
Multiple Primary ◽  
Major Treatment ◽  
Low Incidence ◽  
Standard Practices

ABSTRACT Background: Multiple, primary brain tumors with different histological types occurring in the same patient are extremely rare. Several hypotheses have been proposed, and the pathophysiology of coexisting tumors has long been debated; however, due to low incidence, standard practices for this scenario are still inconclusive. Case Description: The authors describe 6 cases of coexisting tumors. By conducting a literature research focused on the computed tomography (CT) era and patients without prior radiation or phakomatosis. Sixty-five such reported cases were identified. In addition, the authors summarize their experience in 6 patients including histopathological features, chronological presentations, outcomes, mortality, and management from their series as well as from previous cases from the reported literature. Conclusion: The coexistence of multiple, primary brain tumors is an interesting condition. Surgical management remains the major treatment; malignant histology has a poor prognostic factor.

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