The value of Tc-DTPA transit times and NMR T1 measurements in monitoring the progress of renal transplants

1985 ◽  
Vol 6 (2) ◽  
pp. 75-81 ◽  
Author(s):  
H. G. GEMMELL ◽  
F. W. SMITH ◽  
A. INNES ◽  
N. EDWARD ◽  
G. R.D. CATTO
Keyword(s):  
Renal Transplants ◽  
Transit Times

Intercontinental and transcontinental mail transit times from Europe to Berkeley, 1892 to 1941

1986 ◽  
Vol 13 (2) ◽  
pp. 141-154 ◽  
Author(s):  
RUDOLF SCHMID
Keyword(s):  
Transit Times ◽  
In Transit

SUMMARY Mail transit times from Germany to Berkeley, California, are computed for issues of the current awareness journals Botanisches Centralblatt (1880–1945) and the interdisciplinary Naturae Novitates (1879–1944). Issues of the former for 1892 to 1902 averaged 29.3 days (31.2 days if abnormal times are included) in transit from Kassel to Berkeley, with many issues (92) requiring only 20 to 25 days for intercontinental and transcontinental transit. Mail transit of Naturae Novitates from Berlin to Berkeley averaged 40.7 days (42 if abnormal times are included) per issue for 1903 to 1916 and 44 days (51.1 days) per issue for 1922 to 1941 (cumulatively averaging 42 days, or 45.9 days for abnormal times), with some issues in 1906 requiring only 11-12 days for intercontinental and transcontinental transit. A smaller sampling for Nature for 1923 and 1930 gave averages of, respectively, 21.5 and 22.4 days, with a minimum of 14 days in both years. These times are consistent with known transatlantic and transcontinental, ship and rail, mail transit times for these periods, as tabulated from various sources. For perspective, early intercontinental and transcontinental air transit times and pre-1892 intercontinental ship transit times are also tabulated.

Hydrogeological responses in tropical mountainous springs

2019 ◽  
Author(s):  
Ricardo Sánchez-Murillo
Keyword(s):  
Costa Rica ◽  
Isotope Composition ◽  
Central Valley ◽  
Distribution Functions ◽  
Geochemical Composition ◽  
Transit Times ◽  
Management Plans ◽  
Best Fit ◽  
Term Data

This study presents a hydrogeochemical analysis of spring responses (2013-2017) in the tropical mountainous region of the Central Valley of Costa Rica. The isotopic distribution of δ18O and δ2H in rainfall resulted in a highly significant meteoric water line: δ2H = 7.93×δ18O + 10.37 (r2=0.97). Rainfall isotope composition exhibited a strong dependent seasonality. The isotopic variation (δ18O) of two springs within the Barva aquifer was simulated using the FlowPC program to determine mean transit times (MTTs). Exponential-piston and dispersion distribution functions provided the best-fit to the observed isotopic composition at Flores and Sacramento springs, respectively. MTTs corresponded to 1.23±0.03 (Sacramento) and 1.42±0.04 (Flores) years. The greater MTT was represented by a homogeneous geochemical composition at Flores, whereas the smaller MTT at Sacramento is reflected in a more variable geochemical response. The results may be used to enhance modelling efforts in central Costa Rica, whereby scarcity of long-term data limits water resources management plans.

scholarly journals MOST Spacebased Photometry of HD 189733: Precise Timing Measurements for Transits Across an Active Star

2008 ◽  
Vol 4 (S253) ◽  
pp. 459-461
Author(s):  
E. Miller-Ricci ◽  
J. F. Rowe ◽  
D. Sasselov ◽  
J. M. Matthews ◽  
R. Kuschnig ◽  
...  
Keyword(s):  
Orbital Period ◽  
Mass Range ◽  
Active Star ◽  
Precise Timing ◽  
Resonant Orbits ◽  
The Earth ◽  
Test Spot ◽  
Transit Times ◽  
Nearly Continuous ◽  
Parent Star

AbstractWe have measured transit times for HD 189733 passing in front of its bright (V = 7.67) chromospherically active and spotted parent star. Nearly continuous broadband photometry of this system was obtained with the MOST (Microvariability & Oscillations of STars) space telesope during 21 days in August 2006, monitoring 10 consecutive transits. We have used these data to search for deviations from a constant orbital period which can indicate the presence of additional planets in the system that are as yet undetected by Doppler searches. We find no variations above the level of ±45 s, ruling out planets in the Earth-to-Neptune mass range in a number of resonant orbits. We find that a number of complications can arise in measuring transit times for a planet transiting an active star with large star spots. However, such transiting systems are also useful in that they can help to constrain and test spot models. This has implications for the large number of transiting systems expected to be discovered by the CoRoT and Kepler missions.

scholarly journals POS-759 HISTOLOGICAL ANALYSIS OF 3 AND 6 MONTH PROTOCOL BIOPSIES AND OUTCOME SIN ABO INCOMPATIBLE RENAL TRANSPLANTS

2021 ◽  
Vol 6 (4) ◽  
pp. S332
Author(s):  
U. Hegde ◽  
A. Prabhakar ◽  
S. Gang ◽  
M. Rajapurkar ◽  
H. Patel ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Renal Transplants ◽  
Protocol Biopsies

scholarly journals An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 507
Author(s):  
Isabel Gonzalez-Alvarez ◽  
Marival Bermejo ◽  
Yasuhiro Tsume ◽  
Alejandro Ruiz-Picazo ◽  
Marta Gonzalez-Alvarez ◽  
...  
Keyword(s):  
Plasma Concentrations ◽  
In Vitro Dissolution ◽  
Case Examples ◽  
Dissolution Studies ◽  
Weak Bases ◽  
Transit Times ◽  
Class Iib ◽  
The Impact

The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (Arcoxia® as reference and two generic formulations in development) by conducting in vivo predictive dissolution with GIS (Gastro Intestinal Simulator) and computational analysis. Those predictions were compared with the results from previous bioequivalence (BE) human studies. Product dissolution studies were performed using a computer-controlled multicompartmental dissolution device (GIS) equipped with three dissolution chambers, representing stomach, duodenum, and jejunum, with integrated transit times and secretion rates. The measured dissolved amounts were modelled in each compartment with a set of differential equations representing transit, dissolution, and precipitation processes. The observed drug concentration by in vitro dissolution studies were directly convoluted with permeability and disposition parameters from literature to generate the predicted plasma concentrations. The GIS was able to detect the dissolution differences among reference and generic formulations in the gastric chamber where the drug solubility is high (pH 2) while the USP 2 standard dissolution test at pH 2 did not show any difference. Therefore, the current study confirms the importance of multicompartmental dissolution testing for weak bases as observed for other case examples but also the impact of excipients on duodenal and jejunal in vivo behavior.

scholarly journals Simulating a Ground Truth for Transit Time Analysis of Indicator Dilution Curves

2020 ◽  
Vol 6 (3) ◽  
pp. 268-271
Author(s):  
Michael Reiß ◽  
Ady Naber ◽  
Werner Nahm
Keyword(s):  
Transit Time ◽  
Sampling Rate ◽  
Ground Truth ◽  
Indicator Dilution ◽  
Cross Sectional ◽  
In Vivo Measurements ◽  
Multiple Indicator Dilution ◽  
Transit Times ◽  
Dilution Curves

AbstractTransit times of a bolus through an organ can provide valuable information for researchers, technicians and clinicians. Therefore, an indicator is injected and the temporal propagation is monitored at two distinct locations. The transit time extracted from two indicator dilution curves can be used to calculate for example blood flow and thus provide the surgeon with important diagnostic information. However, the performance of methods to determine the transit time Δt cannot be assessed quantitatively due to the lack of a sufficient and trustworthy ground truth derived from in vivo measurements. Therefore, we propose a method to obtain an in silico generated dataset of differently subsampled indicator dilution curves with a ground truth of the transit time. This method allows variations on shape, sampling rate and noise while being accurate and easily configurable. COMSOL Multiphysics is used to simulate a laminar flow through a pipe containing blood analogue. The indicator is modelled as a rectangular function of concentration in a segment of the pipe. Afterwards, a flow is applied and the rectangular function will be diluted. Shape varying dilution curves are obtained by discrete-time measurement of the average dye concentration over different cross-sectional areas of the pipe. One dataset is obtained by duplicating one curve followed by subsampling, delaying and applying noise. Multiple indicator dilution curves were simulated, which are qualitatively matching in vivo measurements. The curves temporal resolution, delay and noise level can be chosen according to the requirements of the field of research. Various datasets, each containing two corresponding dilution curves with an existing ground truth transit time, are now available. With additional knowledge or assumptions regarding the detection-specific transfer function, realistic signal characteristics can be simulated. The accuracy of methods for the assessment of Δt can now be quantitatively compared and their sensitivity to noise evaluated.

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