THE SECOND PRIMARY MALIGNANT TUMOR IN GYNECOLOGY A REVIEW OF THE LITERATURE AND A SERIES PRESENTATION

In classical oncological literature two mechanisms for tissue aggression in patients with cancer have been described. The first is the progressive invasion, infiltration and destruction of tissues surrounding primary malignant tumor or their metastases; the other includes alterations produced in remote sites that are not directly affected by any focus of disease, the so called paraneoplastic phenomenon. The non-invaded tissue which surrounds a primary malignant tumor or its metastases has been usually considered a normal tissue . In this work we describe the ultrastructural changes observed in hepatocytes located next to metastases from diverse malignant tumors.Hepatic biopsies were obtained surgically in patients with different malignant tumors which metatastized in liver. Biopsies included tumor mass, the zone of macroscopic contact between the tumor and the surrounding tissue, and the tissue adjacent to the tumor but outside the macroscopic area of infiltration. The patients (n = 5), 36–75 years old, presented different tumors including rhabdomyosarcoma, leiomyosarcoma, pancreas carcinoma, biliar duct carcinoma and colon carcinoma. Tissue samples were processed with routine techniques for transmission electron microscopy and observed in a Hitachi H-500 electron microscope.

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Primary Malignant Tumor of the Fallopian Tube: CT and MR Features

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2001.45.4.393 ◽

2001 ◽

Vol 45 (4) ◽

pp. 393 ◽

Cited By ~ 2

Author(s):

Yu Ri Kahng ◽

Jeong Kon Kim ◽

Kyoung Sik Cho

Keyword(s):

Fallopian Tube ◽

Malignant Tumor ◽

Primary Malignant Tumor

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Influence of the primary malignant tumor site on the incidence and features of metastatic ovarian tumors

Vojnosanitetski pregled ◽

10.2298/vsp0710691s ◽

2007 ◽

Vol 64 (10) ◽

pp. 691-696 ◽

Cited By ~ 1

Author(s):

Zorica Stanojevic ◽

Biljana Djordjevic ◽

Danijela Zivanovic

Keyword(s):

Malignant Tumor ◽

Malignant Tumors ◽

Statistical Significance ◽

Menopausal Status ◽

Ovarian Tumors ◽

Metastatic Tumors ◽

Primary Tumors ◽

Primary Malignant Tumor ◽

Group A ◽

Group B

Background/Aim. Ovary is the organ of the female reproductive system most commonly affected by metastases. The aim of the study was to determine the frequency and features of metastatic ovarian tumors (MOT) depending on the site of the primary malignant tumor. Methods. The study group consisted of 488 patients with histopathologically confirmed ovarian cancers treated at the Clinic of Oncology, Clinical Center Nis, in the period from 1 January 1998 to 31 December 2005. MOT were found in 41 patients. Regarding the site of the primary malignant tumor, those with secondary ovarian tumor were divided into two groups: group A - primary malignant tumor involving the genital organs (n = 30) and group B - primary malignant tumor of extragenital origin (n = 11). Results. MOT were confirmed in 8.40% (41/488) of the patients. Secondary ovarian malignancies were the consequence of endometrial carcinoma spreading in 73.17%, breast carcinoma in 19.51%, stomach carcinoma in 4.88% and colon carcinoma in 2.44% of the cases. No significant differences were found between the group A and group B by the factors of age, body mass index, parity and menopausal status. Contrary to the group A, metastatic tumors in the group B patients were more commonly asymptomatic (p < 0.001), bilateral (p < 0.05), with larger ovarian diameter (p < 0.05), associated with ascites (p < 0.001) and abdominal metastases (p < 0.01), all of statistical significance. Conclusions. Metastatic tumors made up 8.40% of ovarian neoplasmas. With non-genital primary tumors, secondary ovarian deposits were frequently asymptomatic, bilateral, associated with larger ovarian diameter, ascites and abdominal metastatic deposits, compared to malignant tumors of genital origin.

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Synchronous metaplastic breast carcinoma and lung adenocarcinoma: a rare case and review of the literature

BMJ Case Reports ◽

10.1136/bcr-2019-232421 ◽

2020 ◽

Vol 13 (3) ◽

pp. e232421 ◽

Cited By ~ 1

Author(s):

Rebecca Lane ◽

Felicia Yan ◽

Daniel Higgins ◽

Gauri Agarwal

Keyword(s):

Breast Cancer ◽

Lung Adenocarcinoma ◽

Pulmonary Nodules ◽

Second Primary ◽

Review Of The Literature ◽

Metaplastic Breast Cancer ◽

Platinum Based Chemotherapy ◽

Chemotherapy Agents ◽

Metaplastic Breast Carcinoma

Synchronous primary cancers occur in 1.7% of breast cancer cases and metaplastic breast cancer (MBC) occurs in less than 1% of breast cancer cases. We present a previously healthy 66-year-old woman diagnosed with MBC after surgical resection of a presumed cyst. A second primary cancer, multifocal lung adenocarcinoma, was discovered during the staging process for her MBC. Remarkably she had not experienced pulmonary or constitutional symptoms at the time of diagnosis. She received chemotherapy with paclitaxel and carboplatin, followed by immunotherapy with nivolumab. At 24 months of follow-up after her initial diagnosis, she was breast cancer-free with stable pulmonary nodules. This case highlights that rather than assuming multifocal lesions represent metastasis, biopsies should be considered as clinical management could be significantly altered in the presence of a synchronous cancer. Furthermore, platinum-based chemotherapy agents have potential to be considered in the treatment of MBC.

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Intracranial extension of an eccrine porocarcinoma

Journal of Neurosurgery ◽

10.3171/jns.1999.90.1.0138 ◽

1999 ◽

Vol 90 (1) ◽

pp. 138-140 ◽

Cited By ~ 25

Author(s):

Ann M. Ritter ◽

R. Scott Graham ◽

Barbara Amaker ◽

William C. Broaddus ◽

Harold F. Young

Keyword(s):

Soft Tissue ◽

Malignant Tumor ◽

Clinical Presentation ◽

Intracranial Extension ◽

Pathological Findings ◽

Review Of The Literature ◽

Radiographic Evidence ◽

Content Type ◽

Eccrine Porocarcinoma ◽

Fine Print

✓ Eccrine porocarcinoma is a rare malignant tumor of the true sweat gland. It commonly presents in the lower extremities with lymphatic metastasis. The authors describe the clinical presentation, radiographic evidence, operative discoveries, and pathological findings in a patient with an eccrine porocarcinoma involving the soft tissue of the occiput, which had eroded through the cranium. A review of the literature failed to reveal any other such case. The discussion includes the epidemiology, pathogenesis, treatment, and outcome of eccrine porocarcinomas. The six reported cases of scalp eccrine tumors are reviewed.

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