Major Blood Vessel Injury During Elective Surgery

1958 ◽  
Vol 22 (5) ◽  
pp. 509
Author(s):  
J W Lord ◽  
P W Stone ◽  
W A Cloutier ◽  
L Breidenbach
Author(s):  
Raza Alikhan

Humans have evolved an intricate system that maintains blood in a fluid state. This relies on an intact vascular endothelium modulating vascular tone and forming a barrier between blood components and reactive subendothelial components. It also involves the production of inhibitors of both blood coagulation and platelet aggregation. In addition, haemostatic systems are primed to convert blood from its fluid state to a solid state, to allow the formation of a haemostatic plug, following vessel injury, to stem the flow of blood from or within a blood vessel. This chapter reviews the physiology of haemostasis.


Acta Tropica ◽  
2017 ◽  
Vol 171 ◽  
pp. 213-219 ◽  
Author(s):  
Sivan Padma Priya ◽  
S. Sakinah ◽  
Mok Pooi Ling ◽  
Hui-Yee Chee ◽  
Akon Higuchi ◽  
...  

2013 ◽  
Vol 201 (6) ◽  
pp. 785-796 ◽  
Author(s):  
Kellie R. Machlus ◽  
Joseph E. Italiano

Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets. MKs release platelets through a series of fascinating cell biological events. During maturation, they become polyploid and accumulate massive amounts of protein and membrane. Then, in a cytoskeletal-driven process, they extend long branching processes, designated proplatelets, into sinusoidal blood vessels where they undergo fission to release platelets. Given the need for platelets in many pathological situations, understanding how this process occurs is an active area of research with important clinical applications.


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