Salivary Glands: The pseudocapsule of pleomorphic adenomas (benign mixed tumors). The argument against enucleation

1978 ◽  
Vol 62 (1) ◽  
pp. 134
Author(s):  
A A Clairmont ◽  
G S Richardson ◽  
D C Hanna
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenomas ◽  
Mixed Tumors

scholarly journals Canine Mammary Mixed Tumours: A Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Geovanni Dantas Cassali ◽  
Angélica Cavalheiro Bertagnolli ◽  
Enio Ferreira ◽  
Karine Araújo Damasceno ◽  
Conrado de Oliveira Gamba ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Factors Associated ◽  
Histological Types ◽  
Pleomorphic Adenomas ◽  
Mixed Tumours

Mammary mixed tumours are the most frequent neoplasias in female dogs. In humans, mixed tumours are frequently found in the salivary glands and are known as pleomorphic adenomas. In addition to their histomorphologic similarities, mixed tumours and pleomorphic adenomas have the potential to become malignant and give rise to carcinomas in mixed tumours and carcinomas ex-pleomorphic adenoma, respectively. The factors associated with malignant transformation are still poorly known in the case of canine mixed tumours. However, this form of neoplasia tends to be associated with a better prognosis than other malignant histological types. This paper discusses the main features associated with female canine mammary mixed tumours.

Immunolocalization of ??-Catenin in Pleomorphic Adenomas and Carcinomas Ex-pleomorphic Adenomas of Salivary Glands

2007 ◽  
Vol 15 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Marisa C. L. S. Genelhu ◽  
Helenice Gobbi ◽  
Diele C. B. Arantes ◽  
S??rgio V. Cardoso ◽  
Geovanni D. Cassali
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenomas

First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 81-83 ◽  
Author(s):  
M.L. Voz ◽  
W.J.M. Van de Ven ◽  
K. Kas
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Tumor ◽  
Salivary Gland Tumor ◽  
Transitional Zone ◽  
Chromosome 8 ◽  
Gland Tumor ◽  
Histopathological Classification ◽  
Pleomorphic Adenomas ◽  
Chromosomal Changes

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).

Molecular cloning of chromosome 8q12 aberrations in pleomorphic adenomas of the salivary glands

1997 ◽  
Vol 98 (2) ◽  
pp. 160
Author(s):  
K. Kas ◽  
M.L. Voz ◽  
E. Röijer ◽  
E. Meyen ◽  
A.-K. Åström ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Molecular Cloning ◽  
Pleomorphic Adenomas

MORPHOLOGICAL CHARACTERISTICS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS (ANALYSIS OF THE SURGICAL MATERIAL)

2020 ◽  
Vol 73 (11) ◽  
pp. 2339-2344
Author(s):  
Igor S. Brodetskyi ◽  
Olena O. Dyadyk ◽  
Mykhailo S. Myroshnychenko ◽  
Valentina I. Zaritska
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Tumor Tissue ◽  
Morphological Characteristics ◽  
Structural Diversity ◽  
Absolute Number ◽  
Morphological Features ◽  
Morphometric Study ◽  
Pleomorphic Adenomas ◽  
Active Processes

The aim of the study is to reveal the morphological features of pleomorphic adenomas of the salivary glands during a comprehensive examination of the surgical material. Materials and methods: Surgical material from 30 patients with pleomorphic adenomas of the salivary glands was studied. Microspecimens stained with hematoxylin and eosin were studied, using an Olympus BX-41 microscope (Japan) with subsequent processing with the Olympus DP-soft version 3.1 software, which was used to conduct a morphometric study. By morphometry in the tumor tissue, the specific volumes of the parenchyma and stroma, the thickness of the capsule located between the tumor tissue and the tissue of the salivary gland were determined; the absolute number of vessels in the field of view of the microscope was counted at × 100 magnification. Results: Comprehensive morphological analysis of the surgical material of removed neoplasms of the salivary glands has showed that mesenchymal (15 cases, 50.0%) and mixed (10 cases, 33.3%) variants of pleomorphic adenomas are more common, and less often epithelial variants (5 cases, 16.7%). Pleomorphic adenoma is characterized by a different ratio of the epithelial (parenchymal) and mesenchymal (stromal) components forming this tumor, structural diversity and heterogeneity of the structure of these components, which do not have clear boundaries and are mixed with each other. A characteristic feature of pleomorphic adenoma is also the combination in each case of different types of epithelial cells and the structures that they form, as well as areas of various differentiation of the mesenchymal component. Mesenchymal and mixed variants of pleomorphic adenomas, in comparison with the epithelial variant, are more prone to progression and recurrence, as evidenced by our identified active processes of angiogenesis in tumor tissue, frequent tumor invasion of the capsule, thinning of the capsule or the absence of the capsule, less pronounced infiltration of the capsule by immune cells. Conclusions: The morphological features of mesenchymal, mixed and epithelial variants of pleomorphic adenomas of the salivary glands revealed by the authors should be taken into account by clinicians during choosing the tactics for treating the patient, which will undoubtedly help to reduce the incidence of tumor malignization and its recurrence.

End Results of Surgical Treatment of 622 Cases of Tumors of the Salivary Glands.

1974 ◽  
Vol 60 (4) ◽  
pp. 307-316 ◽  
Author(s):  
Carmelo Vinicio Catania ◽  
Emanuele Galante ◽  
Gaetano Bandieramonte ◽  
Bruno Salvadori
Keyword(s):  
Salivary Glands ◽  
Radical Surgery ◽  
Malignant Tumors ◽  
Survival Rates ◽  
High Rate ◽  
Surgical Removal ◽  
Minor Salivary Glands ◽  
Benign Lesions ◽  
Submandibular Glands ◽  
Mixed Tumors

Surgery was performed on 622 patients with tumors of the salivary glands from 1929 to 1972; the gland affected was the parotid in 527 cases, the submandibular glands in 50, and minor salivary glands of palate and other sites in 45. The analysis of distant results point out that both for benign and malignant tumors total sialoadenectomy must be the treatment of choice, as demonstrated by the high rate of recurrence after local excision or partial resection of the gland, even in cases of surely benign lesions such as mixed tumors. It is worthy of being quoted the high rate of recurrence from cylindromas, especially of the palate (48.5%), after surgical removal. As to malignancies of parotid and submandibular glands 5-years survival rates after radical surgery were of 52 % and 30 % respectively.

Benign Pleomorphic Adenomas of the Salivary Glands

1987 ◽  
Vol 11 (4) ◽  
pp. 620-623 ◽  
Author(s):  
David R. Mirich ◽  
Craig B. McArdle ◽  
Madan V. Kulkarni
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenomas

Radiomics-based differentiation of pleomorphic adenomas and Warthin tumors of salivary glands

2020 ◽  
Author(s):  
Henry J. Areiza-Laverde ◽  
Norberto Malpica-González ◽  
Beatriz Brea ◽  
Andrés E. Castro-Ospina ◽  
Gloria M. Díaz
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenomas

Multiple Pulmonary Pleomorphic Adenomas of Unknown Primary

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S38-S39
Author(s):  
X Liu ◽  
W Miller
Keyword(s):  
Ct Scan ◽  
Salivary Glands ◽  
Lower Lobe ◽  
Unknown Primary ◽  
Benign Tumors ◽  
Low Grade ◽  
Eosinophilic Cytoplasm ◽  
Pleomorphic Adenomas ◽  
Multiple Primary ◽  
History Of

Abstract Introduction/Objective The most common site of pleomorphic adenomas (PAs) is salivary glands, which behave as benign tumors and rarely metastasize. Primary PAs in lungs are exceedingly rare. We report a case of multiple PAs in lungs with an inconclusive origin. Methods A 65-year-old woman had a two-year history of numerous scattered bilateral well-circumscribed pulmonary nodules measuring up to 2.1 cm. She had no prior history of smoking, asbestos exposure and salivary gland diseases, and denied any symptoms. The latest chest computed tomography (CT) scan showed the two largest lower lobe nodules had mildly increased in size compared to two years before. The patient then underwent wedge resections. Results Grossly, the wedge resection specimens showed multiple well-circumscribed, pale tan, firm nodules. Microscopically, the nodules comprised cytologically bland nests of polygonal to plasmacytoid cells with eosinophilic cytoplasm, variably set in a myxoid matrix. Immunohistochemical stains demonstrated that the cells were positive for AE-1/AE-3, S-100, bcl-2 and SOX-10, and negative for chromogranin, smooth muscle actin, p63, calponin, PAX-8, CD34, CD31, HMB-45, melan-A, HHF-35, GATA-3, GFAP and RCC marker; TTF-1 highlighted entrapped pulmonary epithelium but the tumor cells were negative. These findings might suggest metastatic low grade PA from salivary glands. However, the patient’s follow-up examination by an otolaryngologist was normal; the CT scan of her chest and abdomen did not show any remarkable findings other than her lung nodules. Conclusion To our knowledge, this is the first reported case of multiple pulmonary PAs without a preceding primary. It has raised questions about the pathogenesis of multiple PAs in lungs. Could PA present as multiple primary nodules in lungs? Could one primary pulmonary PA generate multiple satellite nodules in lungs? Do multiple primary pulmonary PAs have a different IHC profile than that of a single primary pulmonary PA? More research is needed.

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