Exendin-4 Decreases Blood Glucose Levels, but Does not Affect Other Metabolic Parameters in Transplanted Human Islets from Old and Young Donors

2012 ◽  
Vol 94 (10S) ◽  
pp. 703
Author(s):  
A. Sahraoui ◽  
M. Hoeyem ◽  
D. M. Smith ◽  
L. A. Johansson ◽  
O. Korsgren ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Human Islets ◽  
Metabolic Parameters ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Non-invasive monitoring of glycemia-induced regulation of GLP-1R expression in murine and human islets of langerhans

2020 ◽  
Author(s):  
Ada Admin ◽  
Mijke Buitinga ◽  
Christian M.Cohrs ◽  
Wael A.Eter ◽  
Lieke Claessens-Joosten ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets ◽  
Tracer Uptake ◽  
Expression Levels ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Islet Volume

GLP-1R imaging with radiolabelled exendin has proven to be a powerful tool to quantify beta-cell mass (BCM) <i>in vivo</i>. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood glucose levels on GLP-1R-mediated exendin uptake in both murine and human islets and its implications for BCM quantification. Periods of hyperglycemia significantly reduced exendin uptake in murine and human islets, which was paralleled by a reduction in GLP-1R expression. Detailed mapping of the tracer uptake and insulin and GLP-1R expression conclusively demonstrated that the observed reduction in tracer uptake directly correlates to GLP-1R expression levels. Importantly, the linear correlation between tracer uptake and beta-cell area was maintained in spite of the reduced GLP-1R expression levels. Subsequent normalization of blood glucose levels restored absolute tracer uptake and GLP-1R expression in beta-cells and the observed loss in islet volume was halted. <p>This manuscript emphasizes the potency of nuclear imaging techniques to monitor receptor regulation non-invasively. Our findings have significant implications for clinical practice, indicating that blood glucose levels should be near-normalized for at least three weeks prior to GLP-1R agonist treatment or quantitative radiolabeled exendin imaging for BCM analysis.</p>

scholarly journals Hypericum Perforatum L. Hairy Root Extracts – Regulation of Glycemic, Metabolic, Serum Enzyme and Lipid Profile in Stz - Induced Diabetic Rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Elena Rafailovska ◽  
Oliver Tushevski ◽  
Sonja Gadzovska-Simic ◽  
Suzana Dinevska-Kjovkarovska ◽  
Biljana Miova
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Hairy Root ◽  
Hypericum Perforatum ◽  
Diabetic Rats ◽  
Metabolic Parameters ◽  
Serum Enzyme ◽  
Transgenic Roots ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Apart from currently available therapeutics for the treatment of diabetes mellitus, much attention has been paid to discover phytochemicals from natural resources, mainly due to their low side-effects. Hypericum perforatum hairy root (HR) transformed with Agrobacterium rhizogenes A4 represent prospective experimental system enriched in xanthones, known as potent antidiabetic agents. Thus, the aim of this study was to evaluate HR extracts for their potential antihyperglycemic activity in streptozotocin (STZ)-induced diabetic rats, also compared to the effects of wild-growing Hyperici herba (HH). We conducted an acute-toxicity study, multiple dose study, and 24h blood glucose measurements after a single dose administration of HH and HR (200 mg/kg) in diabetic rats. Furthermore, we examined the effects of 14-days administration of HH and HR extracts on blood glucose levels, metabolic parameters, enzyme, and lipid status in healthy and diabetic rats. Both extracts produced a fall of about 70% in blood glucose level after 24h of administration. Two-week treatment with HH and HR induced a significant decrease (70-72%) in blood glucose levels. Moreover, we found an improvement of the dysregulated metabolic parameters (body weight, food, and water consumption and urine output). Serum enzyme (AST, ALT, and γ-GT) and lipid profile parameters (CHOL, TAG, and HDL) were also improved by both extracts. These findings might provide a new insight for managing diabetic hyperglycemia and dysregulated serum enzyme and lipid profile, using extracts from transgenic roots cultures from H. perforatum.

scholarly journals Engineered mesoporous silica reduces long-term blood glucose and HbA1c, and improves metabolic parameters in prediabetics

Nanomedicine ◽  
2021 ◽  
Author(s):  
Jeanha Baek ◽  
Ghislaine Robert-Nicoud ◽  
Carmen Herrera Hidalgo ◽  
Melissa L Borg ◽  
Muhammad N Iqbal ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Mesoporous Silica ◽  
Multicenter Trial ◽  
Metabolic Parameters ◽  
Open Label ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aim: To investigate the effect of oral consumption of engineered mesoporous silica particles, SiPore15®, on long-term blood glucose levels and other metabolic parameters in individuals with prediabetes and newly diagnosed Type 2 diabetes. Method: An open-label, single-arm, multicenter trial was conducted in which SiPore15 was consumed three times daily for 12 weeks. Hemoglobin A1c (HbA1c, primary end point) and an array of metabolic parameters were measured at baseline and throughout the trial. Result: SiPore15 treatment significantly reduced HbA1c by a clinically meaningful degree and improved several disease-associated parameters with minimal side effects. Conclusion: The results from this study demonstrate the potential use of SiPore15 as a treatment for prediabetes that may also delay or prevent the onset of Type 2 diabetes.

scholarly journals Non-invasive monitoring of glycemia-induced regulation of GLP-1R expression in murine and human islets of langerhans

2020 ◽  
Author(s):  
Ada Admin ◽  
Mijke Buitinga ◽  
Christian M.Cohrs ◽  
Wael A.Eter ◽  
Lieke Claessens-Joosten ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Human Islets ◽  
Tracer Uptake ◽  
Expression Levels ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Islet Volume

GLP-1R imaging with radiolabelled exendin has proven to be a powerful tool to quantify beta-cell mass (BCM) <i>in vivo</i>. As GLP-1R expression is thought to be influenced by glycemic control, we examined the effect of blood glucose levels on GLP-1R-mediated exendin uptake in both murine and human islets and its implications for BCM quantification. Periods of hyperglycemia significantly reduced exendin uptake in murine and human islets, which was paralleled by a reduction in GLP-1R expression. Detailed mapping of the tracer uptake and insulin and GLP-1R expression conclusively demonstrated that the observed reduction in tracer uptake directly correlates to GLP-1R expression levels. Importantly, the linear correlation between tracer uptake and beta-cell area was maintained in spite of the reduced GLP-1R expression levels. Subsequent normalization of blood glucose levels restored absolute tracer uptake and GLP-1R expression in beta-cells and the observed loss in islet volume was halted. <p>This manuscript emphasizes the potency of nuclear imaging techniques to monitor receptor regulation non-invasively. Our findings have significant implications for clinical practice, indicating that blood glucose levels should be near-normalized for at least three weeks prior to GLP-1R agonist treatment or quantitative radiolabeled exendin imaging for BCM analysis.</p>

Intraoperative Changes in Blood Glucose Levels Increase the Risk of Death in Cardiac Surgery

2006 ◽  
Vol 31 (03) ◽  
Author(s):  
H Hager ◽  
E Giorni ◽  
A Felli ◽  
B Mora ◽  
M Hiesmayr ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Glucose ◽  
Glucose Levels ◽  
Risk Of Death ◽  
Blood Glucose Levels

The value of blood glucose levels for the parameters of nocturnal sleep for patients with type 1 diabetes

2017 ◽  
Author(s):  
Ina Darashkevich ◽  
Tatiana Mochort ◽  
Lola Niconova ◽  
Serhey Tishkovsky
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Nocturnal Sleep ◽  
Glucose Levels ◽  
Blood Glucose Levels

Changes in Blood Glucose Levels and Body Weight in Patients Administered Sodium-Glucose Cotransporter 2 Inhibitors

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1167-P
Author(s):  
HUN-SUNG KIM ◽  
EUN YOUNG LEE ◽  
KUN-HO YOON
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sodium Glucose Cotransporter

2167-PUB: Effect of Low-Available Carbohydrate Diet Containing Okara and Konjac on Blood Glucose Levels in Spontaneous Diabetic Torii Fatty Rats

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2167-PUB
Author(s):  
KOHEI SURUGA ◽  
TSUYOSHI TOMITA ◽  
MASAKAZU KOBAYASHI ◽  
TADAHIKO MITSUI ◽  
KAZUNARI KADOKURA
Keyword(s):  
Blood Glucose ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Blood Glucose Levels

776-P: Characteristics of Overnight Blood Glucose Levels Are Related to Sleep Quality in People with Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 776-P
Author(s):  
RACHEL BRANDT ◽  
MINSUN PARK ◽  
LAURIE T. QUINN ◽  
MINSEUNG CHU ◽  
YOUNGKWAN SONG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Sleep Quality ◽  
Glucose Levels ◽  
Blood Glucose Levels

Study of Diabetic Mellitus and Knowledge of Lotion Foot Care on the Community

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Hariyadi DM ◽  
Athiyah U ◽  
Hendradi E ◽  
Rosita N ◽  
Erawati T ◽  
...  
Keyword(s):  
Blood Glucose ◽  
T Test ◽  
Small Scale ◽  
Scale Production ◽  
Foot Care ◽  
Diabetic Mellitus ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Before And After ◽  
History Of

The prevention of Diabetic Mellitus (DM) and its complications is the main aim of this study, in addition to the training of lotion foot care application and the development of small scale industry. The research team delivered knowledge in the form of training on Diabetic Mellitus, healthy food, treatment and prevention of complications, and small-scale production of cosmetic products. The aim of this study was to determine the correlation between training on diabetic and lotion foot care application as preventive measures against diabetic complications on the patient's blood glucose levels in the community of residents in Banyuurip Jaya, Surabaya. It was expected from this training that the knowledge of the residents increases and people living with diabetic undergo lifestyle changes and therefore blood sugar levels can be controlled. The parameters measured in this research were blood glucose levels, the anti diabetic drug types consumed, and compliance on diabetics. This study used the data taken from 60 patients with DM over a period of one month. Questionnaires and log books was used to retrieve data and changes in blood glucose levels in diabetic patients. The results showed the demographic data of patients with type 2 diabetic of 85% female and 15% male, with the range of patients aged of 61-70 years of 46.67% and had history of diabetic (90%). The history of drugs consumed by respondents was anti diabetic drugs such as metformin (40%), glimepiride (33.37%) and insulin (6.67%). In addition, the increased knowledge of DM patients after being given the training compared to before training was shown in several questions in the questionnaire. A statistical analysis using t-test analyzed a correlation between training provided in order to enhance understanding of the patient, as well as correlation with blood glucose levels. A paired T-test showed that there was a relationship between the knowledge of trainees before and after training (p less than 0.05). An interesting result was that there was no relationship between blood glucose levels before and after training provided (p> 0.05).

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