IMPACT OF THE ENERGETIC COMPOSITION OF THE PRIOR MEAL AND ACUTE EXERCISE ON PLASMA C-REACTIVE PROTEIN IN TYPE 2 DIABETICS

2005 ◽  
Vol 25 (5) ◽  
pp. 310
Author(s):  
A Ferland ◽  
S Croteau ◽  
S Lemieux ◽  
J Bergeron ◽  
G Turbide ◽  
...  
Keyword(s):  
Acute Exercise ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Energetic Composition

scholarly journals Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis

2012 ◽  
Vol 7 ◽  
pp. BMI.S9060 ◽  
Author(s):  
Shao-gang Ma ◽  
Yao Jin ◽  
Wen Hu ◽  
Feng Bai ◽  
Wen Xu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Type 2 Diabetic Patients ◽  
Ischemia Modified Albumin ◽  
Protein Levels ◽  
Reactive Protein ◽  
Diabetic Ketosis ◽  
Type 2 Diabetics

Overview To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis. Approach One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis. Results Compared to the controls, the ischemia-modified albumin and C-reactive protein levels were higher in patients with diabetic ketosis and type 2 diabetes at the baseline. The levels of ischemia-modified albumin were higher in patients with type 2 diabetes than in the controls. C-reactive protein and ischemia-modified albumin levels were reduced after insulin treatment. The level of ischemia-modified albumin was an independent risk marker for diabetic ketosis ( OR = 1.085, P = 0.008, 95% CI: 1.022–1.152). Receiver operating characteristic curves revealed that the areas under the curve were 0.917 for the modified albumin and 0.357 for C-reactive protein. Conclusion This study indicates that ischemia-modified albumin was significantly associated with diabetic ketosis and was more sensitive than C-reactive protein in reflecting diabetic ketosis.

scholarly journals Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients

2008 ◽  
Vol 101 (8) ◽  
pp. 1145-1149 ◽  
Author(s):  
An Pan ◽  
Wendy Demark-Wahnefried ◽  
Xingwang Ye ◽  
Zhijie Yu ◽  
Huaixing Li ◽  
...  
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Retinol Binding Protein 4 ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Group 1

Elevated C-reactive protein (CRP), IL-6 and retinol-binding protein 4 (RBP4) levels are associated with insulin resistance and diabetes mellitus. Phytoestrogens (including lignans and isoflavones) may enhance the management of diabetes and are hypothesized to act through inflammation pathways. The present study explored the effects of flaxseed-derived lignan on inflammatory factors and RBP4 concentrations in type 2 diabetics, who have higher levels of these biomarkers. Seventy community-dwelling diabetic patients (twenty-six men and forty-four post-menopausal women) with mild hypercholesterolaemia completed a randomized, double-blind, placebo-controlled, cross-over trial of supplementation with flaxseed-derived lignan capsules (360 mg/d) or placebo for 12 weeks, separated by an 8-week wash-out period. The participants maintained their habitual diets and levels of physical activity. Baseline to follow-up concentrations of CRP increased significantly within the placebo group (1·42 (sem 0·19) v. 1·96 (sem 0·22) mg/l, P < 0·001), but were comparatively unchanged in the lignan-supplemented group (1·67 (sem 0·19) v. 1·90 (sem 0·26) mg/l, P = 0·94); a significant difference was observed between treatments ( − 0·45 (95 % CI − 0·76, − 0·08) mg/l, P = 0·021). This effect was confined to women (P = 0·016), but not observed in men (P = 0·49). No between-treatment differences were found with regard to IL-6 or RBP4; though IL-6 concentrations increased significantly from baseline to follow-up in both groups (P = 0·004 and P < 0·001 following lignan and placebo treatments, respectively). The study suggests that lignan might modulate CRP levels in type 2 diabetics. These results need to be confirmed by further large clinical trials of longer duration.

High-sensitivity C-reactive protein: a novel cardiovascular risk predictor in type 2 diabetics with normal lipid profile

2011 ◽  
Vol 25 (6) ◽  
pp. 368-370 ◽  
Author(s):  
Shilpa B. Asegaonkar ◽  
Amruta Marathe ◽  
Mangesh L. Tekade ◽  
Laxmikant Cherekar ◽  
Jayashree Bavikar ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Protein A ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Risk Predictor

scholarly journals Oxidized LDL and C-reactive protein as markers for detection of accelerated atherosclerosis in type 2 diabetes

2006 ◽  
Vol 59 (3-4) ◽  
pp. 160-164 ◽  
Author(s):  
Zorica Caparevic ◽  
Nada Kostic ◽  
Sanja Ilic ◽  
Dragos Stojanovic ◽  
Ana Ivanovic
Keyword(s):  
Healthy Subjects ◽  
Oxidized Ldl ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Increased Risk ◽  
Hs Crp ◽  
Hypercholesterolemic Subjects

Introduction. High levels of inflammatory markers are associated with an increased risk for development of coronary heart disease (CHD). The aim of this study was to estimate relations between oxidized LDL (oxLDL), C-reactive protein (CRP) and conventional lipid risk factors for CHD in type 2 diabetics without coronary heart disease. Material and methods. Three groups of subjects were included in the study. 44 well-controlled type 2 diabetics (25 female/19 male; 54.50?6.54 years); FBG: 5.67+0.69; HbAlc: 6.5?1.6%) without clinical signs of CHD; the second group included 24 hypercholes-terolemic healthy subjects (14 female/28 male; 51.30?5.76 years). The control group included 24 normocholesterolemic healthy subjects (17 female/12 male; 48.1?8.37 years). Lipid profiles were measured by enzymatic methods. OxLDL was measured by a commercially available sandwich ELISA (Mercodia AB, Uppsala, Sweden). Hs-CRP was measured by chemiluminiscence (Immulite-DPC) using Behring Latex hs-CRP assay. Results. Serum oxLDL levels were significantly higher in diabetic patients (p<0.05) and subjects with hypercholesterolemia (p<0.01) compared with control subjects. Levels of CRP were significantly increased in hypercholesterolemic subjects, compared with controls (p<0.01). Levels of CRP in diabetic patients also were significantly increased compared to those of controls (p<0.05). In type 2 diabetes oxLDL significantly correlated with CRP (r=0.657; p=0.0001), TG:HDL-C ratio (r=0.690; p=0.0001). In hypercholesterolemic subjects oxLDL significantly correlated with oxLDL: LDL ratio (r=0.788; p=0.0001) but not with CRP. In controls, oxLDL significantly correlated with oxLDL: LDL ratio (r=0.679; p=0 0001 and CRP (r=0.802; p=0.0001). Conclusion. It is of great importance to identify type 2 diabetics and hyper-cholesterolemic healthy subjects with high levels of oxLDL and CRP, because they are at increased risk for development of accelerated atherosclerosis. .

scholarly journals GLYCEMIC CONTROL MODIFIES THE ASSOCIATION BETWEEN MICROALBUMINURIA AND C-REACTIVE PROTEIN IN TYPE 2 DIABETES MELLITUS

2020 ◽  
pp. 4-5
Author(s):  
Krishkumar A. Jivani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Diabetes Mellitus Patient ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Type 2 Diabetics ◽  
Group 2

BACKGROUND: HbA1c is most commonly used parameter for glycemic control in type 2 diabetes mellitus patient. AIM The aim of the study was to evaluate whether any association exists between C-reactive protein and microalbuminuria in well controlled and poorly controlled Type 2 DM patients. METHOD : In this study, we included total 90 patients of type 2 Diabetes Mellitus admitted in GKGH , Bhuj during the period from Aug. 2018 to June 2019. The subjects were divided into two groups according to glycemic control as Group 1(Poorly controlled Diabetics) and Group 2( Well controlled Diabetics ) The groups 1 and 2 (based on Glycemic control) were further divided into 3 subgroups A, B and C (based on CRP level) with 15 subjects in each of these six subgroups. RESULT: Subjects with poor glycemic control had elevated values of MAU at all comparative levels of CRP. Further, it was shown that the level of MAU increased considerably with increasing level of CRP. CONCLUSION : There is a significant positive correlation between the level of MAU and CRP status in poorly controlled Type 2 diabetics.

C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Aleš Pleskovič ◽  
Marija Šantl Letonja ◽  
Andreja Cokan Vujkovac ◽  
Jovana Nikolajević Starčević ◽  
Katarina Gazdikova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Carotid Atherosclerosis ◽  
Inflammatory Marker ◽  
Progression Rate ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Unstable Plaques

Abstract. Background: This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). Patients and methods: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP ≥ 2 mg/L and subjects with hs-CRP below 2 mg/L). Results: Subjects with T2DM and hs-CRP levels ≥ 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. Conclusions: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.

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