Multisite Chronic Musculoskeletal Pain Increases The Risk of Falls in Older Adults

2010 ◽  
Vol 25 (1) ◽  
pp. 3
Author(s):  
&NA;
Keyword(s):  
Older Adults ◽  
Musculoskeletal Pain ◽  
Chronic Musculoskeletal Pain ◽  
Risk Of Falls ◽  
Falls In Older Adults

Timed up and go test and risk of falls in older adults: A systematic review

2011 ◽  
Vol 15 (10) ◽  
pp. 933-938 ◽  
Author(s):  
Olivier Beauchet ◽  
B. Fantino ◽  
G. Allali ◽  
S. W. Muir ◽  
M. Montero-Odasso ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Timed Up And Go ◽  
Risk Of Falls ◽  
Falls In Older Adults

scholarly journals Analysis of Falls in Older Adults with Multiple Myeloma Undergoing First-Line Therapy

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 5886-5886
Author(s):  
Kelly L. Schoenbeck ◽  
Tanya M. Wildes ◽  
Mark A. Fiala
Keyword(s):  
Older Adults ◽  
Multiple Myeloma ◽  
Peripheral Neuropathy ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Increased Risk ◽  
Risk Of Falls ◽  
Falls In Older Adults ◽  
First Line Treatment

Background: Patients with multiple myeloma are frequently treated with bortezomib, a proteasome inhibitor, which is associated with treatment-related peripheral neuropathy. Older adults are at increased risk of falls compared to the general population, often leading to associated morbidity and mortality. While an association between peripheral neuropathy and falls in older adults is well-established, the relationship between bortezomib and falls in older multiple myeloma patients is unknown. Our primary aim was to determine if older patients with multiple myeloma treated with bortezomib as first-line therapy had an increased incidence of falls within the first 12 months after starting treatment. Our secondary aim was to assess the overall survival of patients who fell compared to those who did not among patients who lived more than 12 months after initiating treatment. Methods: We analyzed the SEER-Medicare database for all patients 65 years old or older diagnosed with multiple myeloma between 2007 and 2013 and were enrolled in fee-for-service Medicare part A, B and D plans. The patients' corresponding Medicare claims data were analyzed through 2014 for myeloma treatments, fall claims, and covariates of interest. The primary outcome was accidental falls (E880-E888) occurring between 14 days to 12 months after starting multiple myeloma treatment. First-line therapy was defined as any anti-myeloma treatment administered within 14 days of starting multiple myeloma treatment, with bortezomib treatment being the focal independent variable. Cox regression was performed to determine the relative risk of having a fall after controlling for other covariates. Patients who started bortezomib after first-line therapy were censored at time of bortezomib commencement. The survival analysis included only patients who survived more than 12 months of starting treatment to allow landmark analysis of falls in the first year. Results: Of 4,084 older adults with new multiple myeloma diagnoses undergoing first-line therapy, the median age was 75 (range 65-97) with 51% males. Bortezomib was used in first-line therapy for 2,052 (50%) patients, of which 157 (8%) patients experienced a fall within 12 months after starting treatment compared to 102 (5%) of patients not receiving bortezomib (p < 0.001). Bortezomib was associated with a 28% increase risk of falls (HR 1.29; 95% CI 1.00-1.65; p = 0.047). In multivariate analysis, bortezomib was not associated with an increased incidence of falls after controlling for age, gender, race, proxies for Charlson Comorbidity Index (CCI) and poor performance status, pre-existing peripheral neuropathy, falls within the 12 months prior to starting first-line myeloma treatment, depression, polypharmacy, and first-line treatment with lenalidomide (Table 1). Advancing age, history of fall(s), depression, and polypharmacy (defined as more than 10 unique prescription medications at initiation of first-line treatment), were all associated with an increased risk of falls, consistent with prior literature. In a landmark analysis of those who survived 12 months following the start of treatment, a fall was associated with a 26% increased risk of hazard for death (aHR 1.26; 95% CI 1.02-1.56; p = 0.033) after controlling for other covariates. The median OS of those with a fall was 35.7 months (95% CI 29.1-48.4) compared to 49.1 months (95% CI 47.1-52.8) for those without (p < 0.0001). Conclusion: In older adults with multiple myeloma, treatment with bortezomib was not associated with increased risk of a patient having a diagnostic code for falls. However, experiencing a fall within the year after starting treatment was associated with decreased overall survival. Limitations of the study include that the incidence of falls is likely underestimated in billing data, given prior data from our group showing a rate of self-reported falls of 26% in the year after diagnosis. Additional research, including prospective trials involving fall assessments, should be considered in older patients with multiple myeloma. Disclosures Wildes: Janssen: Research Funding; Carevive: Consultancy. Fiala:Incyte: Research Funding.

Sarcopenia and Chronic Musculoskeletal Pain in 729 Community-Dwelling Chinese Older Adults With Multimorbidity

2019 ◽  
Vol 20 (10) ◽  
pp. 1349-1350
Author(s):  
Regina Wing Shan Sit ◽  
Dexing Zhang ◽  
Bo Wang ◽  
Carmen Wong ◽  
Benjamin Hon Kei Yip ◽  
...  
Keyword(s):  
Older Adults ◽  
Musculoskeletal Pain ◽  
Community Dwelling ◽  
Chronic Musculoskeletal Pain ◽  
Chinese Older Adults

scholarly journals Effects of aerobic exercise in the treatment of older adults with chronic musculoskeletal pain: a protocol of a systematic review

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Naiane Teixeira Bastos de Oliveira ◽  
Irlei dos Santos ◽  
Gisela Cristiane Miyamoto ◽  
Cristina Maria Nunes Cabral
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Aerobic Exercise ◽  
Musculoskeletal Pain ◽  
Included Study ◽  
Chronic Musculoskeletal Pain ◽  
Current Evidence ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
And Function

Abstract Background Chronic musculoskeletal pain affects the quality of life of older adults by interfering in their ability to perform activities of daily living. Aerobic exercise programs have been used in the treatment of various health conditions, including musculoskeletal disorders. However, there is still little evidence on the effects of aerobic exercise for the treatment of older adults with chronic musculoskeletal pain. Thus, the objective of this study is to assess the effects of aerobic exercise in improving pain and function of older adults with chronic pain as a consequence of different chronic musculoskeletal conditions. Methods The databases to be used in the search are PubMed, EMBASE, CINAHL, PEDro, and Cochrane Central Register of Controlled Trials (CENTRAL). Randomized controlled trials that used aerobic exercise in the treatment of older adults with chronic musculoskeletal pain will be included. Primary outcomes will be pain and function. We will use the PEDro scale to evaluate the methodological quality and statistical description of each included study, and the strength of the recommendations will be summarized using GRADE. Discussion The results of this systematic review will provide a synthesis of the current evidence on the effects of aerobic exercise in the treatment of older adults with chronic musculoskeletal pain. In addition, this information can help health professionals in decision-making about the use of aerobic exercise in the treatment of older adults with chronic musculoskeletal pain. Ethics and dissemination This systematic review was recorded prospectively, and the results will be part of a doctoral thesis to be published in a peer-reviewed international journal and possibly presented at international conferences. Systematic review registration PROSPERO, CRD42019118903.

Chronic Pain and Risk of Falls in Older Adults

JAMA ◽  
2010 ◽  
Vol 303 (12) ◽  
pp. 1147
Author(s):  
Sylvie Mesrine
Keyword(s):  
Older Adults ◽  
Chronic Pain ◽  
Risk Of Falls ◽  
Falls In Older Adults

scholarly journals Effects of water aerobics on posture alignment and risk of falls of older adults: an intervention study

2021 ◽  
Vol 43 ◽  
Author(s):  
Camila Costa Ibiapina Reis ◽  
Marcos Antônio Pereira dos Santos ◽  
Camila Feitosa da Costa ◽  
Edna Maria Silva Araújo ◽  
Luiz Roberto Ramos
Keyword(s):  
Older Adults ◽  
Fall Risk ◽  
Intervention Study ◽  
Intervention Group ◽  
Control Group ◽  
Body Segments ◽  
Experimental Intervention ◽  
Quasi Experimental ◽  
Risk Of Falls ◽  
Falls In Older Adults

ABSTRACT Considering that aging leads to losses in postural control and balance, our objective was to analyze the effects of water aerobics on posture alignment and risk of falls in older adults. A quasi-experimental intervention study included 49 older adults in the Intervention Group (IG) and 34 in the Control Group (CG). A plumbed symmetrograph assessed posture alignment, while a Time Up & Go test determined the fall risk. The IG performed water aerobics twice a week for three months. Posture alignment significantly improved in most body segments assessed for the IG, and worsened in the CG. The low risk of falls in the IG increased by 28% in relation to the CG. We concluded that water aerobics improved posture alignment and reduced fall risk in older adults.

Sign in / Sign up

Export Citation Format

Share Document