Comparative study on the effects of grape seed extract and telmisartan on doxorubicin-induced cardiotoxicity in adult male rats

2012 ◽  
Vol 35 (2) ◽  
pp. 340-352 ◽  
Author(s):  
Abeer A. Abd El Samad ◽  
Mona H. Raafat
Keyword(s):  
Comparative Study ◽  
Adult Male ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Male Rats

Grape Seed and Physalis Extracts as Anti- Inflammatory Agents in Cetuximab Induced Tongue Mucositis in Rats

2020 ◽  
Vol 20 (3) ◽  
pp. 173
Author(s):  
Heba A. Saleh ◽  
Manar A. Abdul Aziz ◽  
Mona E. Wali
Keyword(s):  
Mast Cells ◽  
Cancer Therapy ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Male Rats ◽  
Control Group ◽  
Tissue Preparation ◽  
Group I ◽  
Area Percent

<strong>Background:</strong> Oral mucositis induced by cancer therapy alters cancer patient’s life. Nutraceuticals these days is for their various activities which could neutralize the toxicity induced by cancer treatment. <strong>Purpose:</strong> Comparision between the effect of grape seed and fruits of <em>Physalis peruviana</em> methanol extract in reduction of mucositis induced by Cetuximab drug. <strong>Study Design:</strong> Animal study. <strong>Methods:</strong> 60 male rats divided into 6 groups as 10 in each group. Control group of rats with no intervention given. The other 5 groups were given Cetuximab drug alone or with grape seed extract (simultaneously or 1 week before Cetuximab drug) or <em>Physalis </em>extract (simultanously or 1 week before Cetuximab drug). After sacrifice, tongue was dissected and tissue preparation was done for all samples. Digital counting was done by image analyzer computer system for (a) filliform papillae in H&amp;E stained sections, (b) mast cells in mast cell tryptase stained sections to assess inflammation. The area percent for bax immune-expression in other immune stained sections were also measured done to assess apoptosis. <strong>Results:</strong> The difference between the groups was assessed for statistical significance (P&lt;0.0001) by ANOVA test. The greatest mean number of filiform papillae was recorded in control group I. Greatest mean number of mast cells and the greatest mean area percent of bax immune expression were recorded in group II. <strong>Conclusion:</strong> Grape seed extract and <em>Physalis extract</em> could neutralize the harmful effect of cancer therapy. <em>Physalis extract</em> had more potent effect in reducing the inflammation induced by Cetuximab drug.

scholarly journals grape seed extract role against L-Thyroxine effects on thyroid gland and lipid profile

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Ahmed AL-Naely ◽  
Dalal Shattnan
Keyword(s):  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Lipid Profile ◽  
Thyroid Tissue ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Male Rats ◽  
Control Group ◽  
Normal Range

The aim of the current study is identify role grape seed extract on thyroid gland tissues, hormones and lipid profile disorders induced by L-Thyroxine by used dose 20 mg/kg. The experience including 40 male rats randomly divided into five groups each group consist of 8 animals,  grape seed extract dose 150mg/kg  daily for 30-day. Results showed that the animals treated with L-Thyroxine had significant increase(P<0.05) in  thyroid hormones concentration  and dencrease TSH hormone compared with their normal range level in the control group and the rest of the experiment groups, While groups in which grape seed extract (GSE) interferes with drug showed improvement in thyroid hormones level closer to normal range in control group. Also the results showed significant decrease (P<0.05) in TC, TG HDL, vLDL and in L-Thyroxine group, in addition to  thyroid tissue damage.  On the other hand animals treated by both grape seed extract (GSE) and drug showed significant improvement(P<0.05) in TC, TG, HDL, vLDL, LDL and thyroid tissue compared with groups treated with drug only. It was concluded from this study that grape seeds extract had protective role against damage caused by L-Thyroxine.

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