The possible protective effect of piperine versus vitamin C on monosodium glutamate-induced cerebellar toxicity in adult male rats

2016 ◽  
Vol 39 (4) ◽  
pp. 362-371
Author(s):  
Abeer I. Omar ◽  
Eman A. Farag ◽  
Marwa M. Yousry
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Adult Male ◽  
Monosodium Glutamate ◽  
Male Rats

scholarly journals Potential Protective Effect of Vitamin C on Qunalphos-Induced Cardiac Toxicity: Histological and Tissue Biomarker Assay

Biomedicines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 39
Author(s):  
Ayed A. Shati ◽  
Mohamed Samir A. Zaki ◽  
Youssef A. Alqahtani ◽  
Mohamed A. Haidara ◽  
Mubarak Al-Shraim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Protective Effect ◽  
Cardiac Tissue ◽  
Electron Microscopic Examination ◽  
Male Rats ◽  
Cardiac Damage ◽  
Electron Microscopic ◽  
Necrosis Factor Alpha ◽  
Vit C

Insecticides and toxicants abound in nature, posing a health risk to humans. Concurrent exposure to many environmental contaminants has been demonstrated to harm myocardial performance and reduce cardiac oxidative stress. The purpose of this research was to study the protective effect of vitamin C (Vit C) on quinalphos (QP)-induced cardiac tissue damage in rats. Eighteen albino male rats were randomly categorised into three groups (n = 6). Control, QP group: rats received distilled water. QP insecticide treatment: an oral administration of QP incorporated in drinking water. QP + Vit C group: rats received QP and Vit C. All the experiments were conducted for ten days. Decline of cardiac antioxidant biomarkers catalase (CAT) and reduced glutathione (GPx) along with increased proinflammatory markers tumour necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) indicated oxidative and inflammatory damage to the heart following administration of QP when compared to control rats. The light microscopic and ultrastructure appearance of QP-treated cardiomyocytes exhibited cardiac damage. Administration of Vit C showed decreased oxidative and inflammatory biomarkers, confirmed with histological and electron microscopic examination. In conclusion, Vit C protected the heart from QP-induced cardiac damage due to decreased inflammation and oxidative stress.

Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats

2018 ◽  
Vol 391 (7) ◽  
pp. 729-742 ◽  
Author(s):  
Rania I. Nadeem ◽  
Hebatalla I. Ahmed ◽  
Bahia M. El-Sayeh
Keyword(s):  
Protective Effect ◽  
Adult Male ◽  
Male Rats

Cilostazol Effect on Amikacin-Induced Ototoxicity: An Experimental Study

2016 ◽  
Vol 21 (4) ◽  
pp. 250-253 ◽  
Author(s):  
Mohammad Waheed El-Anwar ◽  
Said Abdelmonem ◽  
Ebtessam Nada ◽  
Dalia Galhoom ◽  
Ahmed A. Abdelsameea
Keyword(s):  
Experimental Study ◽  
Protective Effect ◽  
Adult Male ◽  
Otoacoustic Emissions ◽  
Male Rats ◽  
Control Group ◽  
Once Daily ◽  
Frequency Bands ◽  
Transient Evoked Otoacoustic Emissions

Objectives: To find out the possible protective effect of cilostazol against amikacin-induced ototoxicity. Methods: This study was carried out on 24 adult male rats classified into 4 equal groups of 6 animals each. (1) The control group was administered saline (1 ml/day, p.o.) for 14 days. (2) The amikacin group was administered amikacin (200 mg/kg, i.m.) once daily for 14 days. (3) The cilostazol-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily and amikacin (200 mg/kg, i.m.) once daily for 14 days. (4) The cilostazol (28 days)-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily for 28 days and amikacin (200 mg/kg, i.m.) once daily for 14 days. Changes in the transient evoked otoacoustic emissions (TEOAEs) in the 4 groups were interpreted statistically. Results: No reported significant differences in TEOAE levels were detected between the groups at the start of the study. In all frequency bands, TEOAEs disappeared after amikacin treatment in the amikacin-alone group and remained absent in the amikacin-cilostazol (14 days) group, while TEOAEs reappeared in the amikacin-cilostazol (28 days) group. Conclusion: Cilostazol treatment for 28 days had a protective effect against amikacin-induced ototoxicity in rats.

Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

2014 ◽  
Vol 24 (5) ◽  
pp. 1063-1068 ◽  
Author(s):  
Syma Ashraf Waiz ◽  
Mohammad Raies-ul-Haq ◽  
Hina Ashraf Waiz ◽  
Suman Gupta ◽  
A. K. Pathak
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Monosodium Glutamate ◽  
Preliminary Study
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