scholarly journals Toxicity of monosodium glutamate on liver and body weight with the protective effect of tannic acid in adult male rats

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Palkis Mohamed ◽  
Rania Radwan ◽  
Sherine Mohamed ◽  
Soheir Mohamed
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Tannic Acid ◽  
Adult Male ◽  
Monosodium Glutamate ◽  
Male Rats

Dietary fat and adiposity: a dose-response relationship in adult male rats fed isocalorically

1995 ◽  
Vol 268 (4) ◽  
pp. E546-E550 ◽  
Author(s):  
C. N. Boozer ◽  
G. Schoenbach ◽  
R. L. Atkinson
Keyword(s):  
Body Weight ◽  
Body Fat ◽  
Adult Male ◽  
Dietary Fat ◽  
Male Rats ◽  
Control Group ◽  
Low Fat Diet ◽  
Mesenteric Fat ◽  
Total Body Fat ◽  
Total Body

This study examined the effects of increasing levels of dietary fat fed isocalorically on body weight, body composition, and adipose distribution. Adult male rats were weight matched into four groups. One group that was fed a low-fat diet (12%) served as reference controls. The other three groups were fed diets of 24, 36, or 48% fat in amounts to equal the energy intake of the control group. After 6 wk, body weights of the four groups were not significantly different. Intrascapular brown fat did not differ between groups. Total body fat and adipose depot weights, however, increased in proportion to the level of fat in the diet. Total body fat and retroperitoneal and mesenteric depot weights of the 48% fat group were greater than controls (P < 0.05). Mesenteric fat in this group was also significantly increased over all other groups (P < 0.05). These results show that high-fat diets fed to adult animals cause increased body fat in the absence of significant changes in body weight and that mesenteric fat is increased disproportionately.

Protective effect of vinpocetine against neurotoxicity of manganese in adult male rats

2018 ◽  
Vol 391 (7) ◽  
pp. 729-742 ◽  
Author(s):  
Rania I. Nadeem ◽  
Hebatalla I. Ahmed ◽  
Bahia M. El-Sayeh
Keyword(s):  
Protective Effect ◽  
Adult Male ◽  
Male Rats

scholarly journals In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat

2000 ◽  
pp. 406-410 ◽  
Author(s):  
M Tena-Sempere ◽  
L Pinilla ◽  
LC Gonzalez ◽  
J Navarro ◽  
C Dieguez ◽  
...  
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Body Weight Gain ◽  
Biologically Active ◽  
Male Rats ◽  
Male Rat ◽  
Gh Secretion ◽  
Adult Rat ◽  
Testosterone Secretion

The obese gene (ob) product, leptin, has recently emerged as a key element in body weight homeostasis, neuroendocrine function and fertility. Identification of biologically active, readily synthesized fragments of the leptin molecule has drawn considerable attention, as they may provide a powerful tool for detailed characterization of the biological actions of leptin in different experimental settings. Recently, a fragment of mouse leptin protein comprising amino acids 116-130, termed leptin(116-130) amide, was shown to mimic the effects of the native molecule in terms of body weight gain and food intake, and to elicit LH and prolactin (PRL) secretion in vivo. As a continuation of our previous experimental work, the present study reports on the effects of leptin(116-130) amide on basal and stimulated testosterone secretion by adult rat testis in vitro. In addition, a comparison of the effects of human recombinant leptin and leptin(116-130) amide at the pituitary level on the patterns of LH, FSH, PRL and GH secretion is presented. As reported previously by our group, human recombinant leptin(10(-9)-10(-7)M) significantly inhibited both basal and human chorionic gonadotrophin (hCG)-stimulated testosterone secretion in vitro. Similarly, incubation of testicular tissue in the presence of increasing concentrations of leptin(116-130) amide (10(-9)-10(-5)M) resulted in a dose-dependent inhibition of basal and hCG-stimulated testosterone secretion; a reduction that was significant from a dose of 10(-7)M upwards. In addition, leptin(116-130) amide, at all doses tested (10(-9)-10(-5)M), significantly decreased LH and FSH secretion by incubated hemi-pituitaries from adult male rats. In contrast, in the same experimental protocol, recombinant leptin(10(-9)-10(-7)M) was ineffective in modulating LH and FSH release. Finally, neither recombinant leptin nor leptin(116-130) amide were able to change basal PRL and GH secretion in vitro. Our results confirm the ability of leptin, acting at the testicular level, to inhibit testosterone secretion, and map the effect to a domain of the leptin molecule that lies between amino acid residues 116 and 130. In addition, we provide evidence for a direct inhibitory action of leptin(116-130) amide on pituitary LH and FSH secretion, a phenomenon not observed for the native leptin molecule, in the adult male rat.

Effects of Insulin, Metrazol, and Electroconvulsive Shocks upon Learning to Learn 30 Successive Reversal Problems by Rats

1970 ◽  
Vol 26 (2) ◽  
pp. 551-558 ◽  
Author(s):  
Loh Seng Tsai ◽  
Vernon J. Perez ◽  
Jefferson M. Koonce
Keyword(s):  
Body Weight ◽  
Potassium Chloride ◽  
Electric Current ◽  
Adult Male ◽  
Male Rats ◽  
Learning To Learn ◽  
Successive Reversal ◽  
Insulin Group ◽  
Weight One ◽  
Better Than

To determine the relative effects of insulin, metrazol and electroconvulsive shocks upon learning to learn 30 successive reversal problems by rats, an enclosed square T-maze was used, with water as incentive after 23 hr. of deprivation. S had to achieve 9 correct out of 10 daily trials before a problem was reversed. 40 adult male rats were equally divided into a control and 3 differently shocked groups. Shocks were administered on 3 alternate days followed by 2 days of rest. Each time, Ss of the 4 groups received respectively 0.5 cc. of saline, 55 mg. of metrazol per kg. of body-weight, one unit of insulin per 20 gm. of body-weight, and an electric current of 50 ma. at 25 v for 150 msec. Convulsion in the insulin group was prevented by an injection of dextrose and potassium chloride. The control was significantly superior to the 3 shocked groups which were remarkably similar or practically identical in their performance during the initial 6 problems. Thereafter, both the non-convulsive (saline and insulin) groups did better than the 2 convulsive groups either in terms of error, day, or one-trial reversal score.

The effect of a single injection of estradiol benzoate on thyroid function in intact male rats

1968 ◽  
Vol 46 (4) ◽  
pp. 697-700 ◽  
Author(s):  
K. Brown-Grant
Keyword(s):  
Body Weight ◽  
Thyroid Gland ◽  
Thyroid Function ◽  
Dose Level ◽  
Adult Male ◽  
Single Injection ◽  
Estradiol Benzoate ◽  
Male Rats ◽  
Intact Male ◽  
Federation Proc

The changes observed in the metabolism of radioiodide and radiophosphorus by the thyroid gland of intact adult male rats following a single injection of estradiol benzoate (4 μg/100 g body weight) are consistent with the suggestion (F. Labrie, G. Pelletier, and C. Fortier. Federation Proc. 26, 484 (1967). Abstr.) that at this dose level estrogen causes a hypersecretion of TSH in such animals.

scholarly journals Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats

2014 ◽  
Vol 11 (1) ◽  
pp. 36 ◽  
Author(s):  
Clare L Adam ◽  
Patricia A Williams ◽  
Matthew J Dalby ◽  
Karen Garden ◽  
Lynn M Thomson ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Young Adult ◽  
Food Intake ◽  
Adult Male ◽  
Dietary Fibre ◽  
Body Weight Gain ◽  
Male Rats ◽  
Decrease Food Intake ◽  
Different Types

GONADOTROPHIN SUPPRESSION BY STEROIDS IN NORMAL, ADULT MALE RATS

1977 ◽  
Vol 84 (4) ◽  
pp. 842-849 ◽  
Author(s):  
H. L. Verjans ◽  
K. B. Eik-Nes
Keyword(s):  
Body Weight ◽  
High Activity ◽  
Adult Male ◽  
Subcutaneous Administration ◽  
Serum Levels ◽  
Steroid Treatment ◽  
Male Rats ◽  
Normal Adult ◽  
Serum Lh ◽  
Testosterone Metabolites

ABSTRACT Effects of subcutaneous administration of various doses of different steroids on serum levels of LH and FSH in normal, adult male rats were investigated. Each steroid was injected daily during 7 days in doses of 50, 25, 12.5 or 6.25 μg per 100 g body weight. Ring A 5α-reduced testosterone metabolites exerted high activity in suppressing serum LH and FSH levels. 5α-Androstane-3β,17β-diol had in the doses tested, however, no such effects on serum gonadotrophins. Serum LH concentrations in normal rats appeared more sensitive to steroid treatment than serum FSH concentrations.

STUDIES ON ALDOSTERONE: III. CHRONIC EFFECT ON THE BLOOD PRESSURE OF RATS

1960 ◽  
Vol 38 (1) ◽  
pp. 43-50 ◽  
Author(s):  
A. G. Gornall ◽  
H. M. Grundy ◽  
C. J. Koladich
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Protective Effect ◽  
Systolic Blood Pressure ◽  
Low Dose ◽  
Aqueous Ethanol ◽  
Young Male ◽  
Male Rats ◽  
Chronic Effect ◽  
Dose Levels

A rise in systolic blood pressure due to the administration of 0.4 or 0.5 μg of aldosterone per 100 g body weight to young male rats, over a period of 3 to 6 months, has been confirmed in two separate experiments. This effect was observed whether the aldosterone was given 3 days a week or 6 days a week, and whether dissolved in aqueous ethanol or in oil. Equal doses of 9-α-fluorohydrocortisone and of 2-methyl-9-α-fluorohydrocortisone produced similar though somewhat less consistent effects. When 4 or 5 μg of reserpine was administered along with aldosterone there was no clear evidence of a protective effect. Reserpine alone at these low dose levels was somewhat toxic in the rat and led to a rise in blood pressure.

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