CORRELATION BETWEEN PEANUT SKIN PHENOLIC COMPOUNDS AND THEIR EFFECTS ON DYSLIPIDEMIA IN SWISS MICE

Background: Plant phenolics, commonly present in legumes, leafy vegetables, fruits, grains are a key source of bioactive nutrients existing as flavonols, flavanones, flavanols, phytosterols, among others. Peanuts, being crops of high commercial use, undergo processing that generates voluminous agro-wastes. The waste comprises both the shells and skins, which could be valorized. Its versatile functionality has encouraged extensive research into peanut skin-derived chemicals for diverse applications over the past few decades. Peanut skin, however, is ascertained to be rich in flavonoids, stilbenes (resveratrol), and other phenolic compounds. Methods: This review presents the biologically active compounds and pharmacological activities of peanut skins and their related works over the past few years. Articles carefully chosen from broad databases such as Scopus, Science Direct, Pub Med, SciFinder, among others, were used as the primary data. Results: The bioactive components of peanut skin extracts exhibit anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, anti-cancer/anti-tumour, anti-cardiovascular, and anti-diabetes/obesity activities via in vitro and in vivo models. Besides, their varied biological properties make them potential precursors for the management of diverse diseases and ailments. Potential applications: Phytochemicals from peanut skins could be deployed as an antioxidant, antidiabetic and antimicrobial agents in drugs for the clinical treatment of ailments with extensive clinical applications. Conclusion: The present review covers the chemistry and pharmacological activities of peanut skin phytochemicals. Our findings in this review substantiate the importance of peanut skin extracts and their varied potential for the treatment of specific diseases. The results indicate that they are attractive target compounds for the development of new drugs. We hope that this information will inform further in vivo studies on the role of peanut skin phenolic compounds in our health.

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Characterization of oral disintegrating film of peanut skin extract—Potential route for buccal delivery of phenolic compounds

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2017.01.044 ◽

2017 ◽

Vol 97 ◽

pp. 418-425 ◽

Cited By ~ 13

Author(s):

Marcela P. Tedesco ◽

Carla A. Monaco-Lourenço ◽

Rosemary A. Carvalho

Keyword(s):

Phenolic Compounds ◽

Skin Extract ◽

Buccal Delivery ◽

Peanut Skin

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Interaction of polyphenols extract from Polygonum multiflorum Thunb. roots with gelatin and toxicity of extract in mice

Potravinarstvo Slovak Journal of Food Sciences ◽

10.5219/1222 ◽

2020 ◽

Vol 14 ◽

pp. 17-23

Author(s):

Le Pham Tan Quoc

Keyword(s):

Phenolic Compounds ◽

Antioxidant Capacity ◽

Bioactive Compounds ◽

Food Industry ◽

Polygonum Multiflorum ◽

Subacute Toxicity ◽

Swiss Mice ◽

Processed Form ◽

Protein Enzyme

The roots of Polygonum multiflorum Thunb. (Vietnamese name: Ha-thu-o-do, HTOD) are used in processed form or the raw state in traditional Vietnamese medicine for many diseases and in extract form in the food industry. Some studies pointed out that HTOD extract had toxicity in humans. However, the toxicity of this herb plant currently remains unclear. In addition, this material contained a large amount of bioactive compounds, especially phenolic compounds. They have a strong antioxidant capacity and they can also interact with many different substrates such as protein, enzyme, lipid and carbohydrate. In this study, the received extracts from HTOD had the polyphenols concentrations of 415, 277, 208 and 166 (mg GAE.L-1), respectively. Besides, we only evaluated the gelatin-polyphenols interaction and the toxicity of HTOD extract in Swiss mice. The results show a strong gelatin-polyphenols interaction and no acute or subacute toxicity in mice. The polyphenols extract of HTOD at the concentration tested in this study is safe to use in food.

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Development of a reversed-phase high performance liquid chromatography (RP-HPLC) procedure for the simultaneous determination of phenolic compounds in peanut skin extracts

Food Chemistry ◽

10.1016/j.foodchem.2009.03.110 ◽

2009 ◽

Vol 117 (2) ◽

pp. 356-363 ◽

Cited By ~ 39

Author(s):

Maria Leonora dL. Francisco ◽

A.V.A. Resurreccion

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Phenolic Compounds ◽

Simultaneous Determination ◽

High Performance ◽

Reversed Phase ◽

Peanut Skin ◽

Rp Hplc

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Alteration of Mitochondria in Oxythiamine-Induced, Acute Thiamine Deficiency in the Mouse

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100091408 ◽

1976 ◽

Vol 34 ◽

pp. 284-285

Author(s):

Itaru Watanabe ◽

Dante G. Scarpelli

Keyword(s):

Electron Microscopy ◽

Adult Male ◽

Thiamine Deficiency ◽

Light And Electron Microscopy ◽

Fatty Change ◽

Deficient Diet ◽

Subcutaneous Injections ◽

Swiss Mice ◽

Time Period ◽

Ad Libitum

Acute thiamine deficiency was produced in mice by the administration of oxythiamine, a thiamine analogue, superimposed upon a thiamine deficient diet. Adult male Swiss mice (30 gm. B.W.) were fed with a thiamine deficient diet ad libitumand were injected with oxythiamine (170 mg/Kg B.W.) subcutaneously on days 4 and 10. On day 11, severe lassitude and anorexia developed, followed by death within 48 hours. The animals treated daily with subcutaneous injections of thiamine (300 μg/Kg B.W.) from day 11 through 15 were kept alive. Similarly, feeding with a diet containing thiamine (600 μg/Kg B.W./day) from day 9 through 17 reversed the condition. During this time period, no fatal illness occurred in the controls which were pair-fed with a thiamine deficient diet.The oxythiamine-treated mice showed a significant enlargement of the liver, which weighed approximately 1.5 times as much as that of the pair-fed controls. By light and electron microscopy, the hepatocytes were markedly swollen due to severe fatty change and swelling of the mitochondria.

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