scholarly journals PE-7: Glepaglutide Pharmacokinetic Profile after Single Subcutaneous Injection in Human Subjects with Varying Degrees of Renal Function

2021 ◽  
Vol 105 (7S) ◽  
pp. S32-S32
Author(s):  
Askjær Agersnap M ◽  
Sonne K ◽  
Knudsen K ◽  
Wladyslaw S
Keyword(s):  
Renal Function ◽  
Subcutaneous Injection ◽  
Human Subjects ◽  
Pharmacokinetic Profile ◽  
Single Subcutaneous Injection

Superovulatory response to single subcutaneous injection of Folltropin in Holstein and Sahiwal cows

1992 ◽  
Vol 37 (1) ◽  
pp. 260 ◽  
Author(s):  
A.K. Misra ◽  
S.A. Chaubal ◽  
G. Krishna Kishore ◽  
S. Rajeshwaran ◽  
B.V. Joshi ◽  
...  
Keyword(s):  
Subcutaneous Injection ◽  
Single Subcutaneous Injection ◽  
Sahiwal Cows

HORMONAL REQUIREMENTS FOR THE MAINTENANCE OF OESTRADIOL-INDUCED INHIBITION OF UTERINE SENSITIVITY IN THE OVARIECTOMIZED RAT

1970 ◽  
Vol 46 (3) ◽  
pp. 341-346 ◽  
Author(s):  
K. P. MEYERS
Keyword(s):  
Subcutaneous Injection ◽  
Ovariectomized Rats ◽  
Ovariectomized Rat ◽  
Single Subcutaneous Injection ◽  
The Third ◽  
Oestradiol Treatment ◽  
Progesterone Treatment ◽  
Endometrial Scratching

SUMMARY Ovariectomized rats treated with 2·5 or 5·0 mg. progesterone daily received a single subcutaneous injection of 0·2 μg. oestradiol on the third day of the progesterone treatment. The deciduomal response to trauma by endometrial scratching was used to determine the degree of uterine sensitivity at various times after oestradiol. Uterine sensitivity was partially and then completely lost 36 and 48 hr. after oestradiol administration. The inhibition of uterine sensitivity persisted until 9 and 11 days after oestradiol when the animals received 2·5 and 5·0 mg. progesterone daily. Uterine sensitivity was completely inhibited on day 11 with doses of oestradiol from 0·2 to 0·05 μg. Withdrawal of progesterone treatment for 48 or 72 hr., but not for 24 hr., after oestradiol treatment restored uterine sensitivity. These results show that the oestradiol-induced inhibition of uterine sensitivity in the progestational endometrium is maintained by continuous progesterone treatment and that the duration of this effect is dependent on the dose of progesterone given.

OBSERVATIONS ON CADMIUM DAMAGE AND REPAIR IN RAT TESTES AND THE EFFECTS ON THE PITUITARY GONADOTROPHS

1962 ◽  
Vol 24 (4) ◽  
pp. 453-NP ◽  
Author(s):  
M. ALLANSON ◽  
R. DEANESLY
Keyword(s):  
Subcutaneous Injection ◽  
Cadmium Chloride ◽  
Cytological Study ◽  
Interstitial Cells ◽  
Germinal Epithelium ◽  
Seminiferous Tubules ◽  
Interstitial Tissue ◽  
Long Term Effects ◽  
Single Subcutaneous Injection

SUMMARY Cadmium chloride, in a single subcutaneous injection, can destroy spermatogenic and interstitial cells in the rat testis (Pařízek, 1957) and produce changes in the pituitary. The interstitial tissue is restored by ingrowths from the tunica and full androgen secretion returns before there is any regeneration of germinal epithelium. A cytological study has been made of the peripheral and central pituitary gonadotrophs; the latter revert almost to normal as the interstitial tissue regenerates, whereas the former retain characteristic castration features, unless there is also regeneration of the germinal epithelium. This seems to indicate that in the normal testis there is a hormone contribution from the seminiferous tubules as well as from the interstitial cells. The long-term effects of cadmium on the testis depend on the dose. Early stages of tubule restoration have been studied, but after administration of 0·9 mg., actual proliferation of the germinal epithelium was rarely found—only in four out of twenty rats, 113 or 142 days after injection.

scholarly journals Dissemination and immunogenicity of live TRIC agent in baboons after parenteral injection: II. Experiments with a ‘slow-killing’ strain

1969 ◽  
Vol 67 (3) ◽  
pp. 449-455 ◽  
Author(s):  
L. H. Collier ◽  
Anne E. Mogg(Née Smith)
Keyword(s):  
Lymph Nodes ◽  
Subcutaneous Injection ◽  
Technical Assistance ◽  
Regional Lymph Nodes ◽  
Virulent Mutant ◽  
Single Subcutaneous Injection ◽  
Single Intravenous Injection ◽  
Peripheral Lymph ◽  
Homologous Strain ◽  
The Difference

SUMMARYAfter a single subcutaneous injection into baboons the MRC-4 strain of trachoma/inclusion conjunctivitis (TRIC) agent underwent limited multiplication at the injection site, but was then eliminated rapidly from the skin and regional lymph nodes. Forty-eight hours after a single intravenous injection, but not thereafter, it appeared in the peripheral lymph nodes and spleen. The single parenteral injections failed to immunize baboons against conjunctival challenge with the homologous strain. These findings contrasted with those previously reported for the more virulent mutant, MRC-4 f, which multiplied readily in the skin, lymph nodes and spleen, persisted in these tissues up to 3 weeks after injection, and conferred good immunity to conjunctival challenge with MRC-4. The difference in behaviour of MRC-4 and MRC-4 f might be accounted for, at least in part, by the use of a smaller inoculum of live MRC-4; but similar findings in guinea-pigs, reported elsewhere, suggest that the differences observed are real. In conjunction with previous work, the present study suggests that the immunogenicity of TRIC agent is closely related to the mass of antigen that can be administered to or propagated within the recipient.We are grateful to Mr D. Venters for his able technical assistance.

SENSITIZATION BY INSULIN TO THE DEXTRAN "ANAPHYLACTOID" REACTION

1957 ◽  
Vol 35 (1) ◽  
pp. 251-256 ◽  
Author(s):  
V. W. Adamkiewicz ◽  
Y. Langlois
Keyword(s):  
Small Dose ◽  
Subcutaneous Injection ◽  
Anaphylactoid Reaction ◽  
Crystalline Insulin ◽  
Single Subcutaneous Injection ◽  
Small Doses

A single subcutaneous injection of crystalline insulin (20 units) sensitizes considerably the rats to the dextran "anaphylactoid" reaction. This is a type of acute serous inflammation. Insulin precipitates the reaction after a very small dose of dextran (0.05–0.01 ml., 6% solution) has been injected into a "shock organ". Without insulin, such small doses of dextran are quite ineffective. Insulin also precipitates the reaction when dextran (1.0 ml., 6% solution) is injected peripherally on the back. In this site and at this dose, it rarely produces the reaction in normal rats. The sensitization manifests itself despite a cortisone pretreatment.

Antithrombotic and Anticoagulant Activities of a Low Molecular Weight Fucoidan by the Subcutaneous Route

1999 ◽  
Vol 81 (03) ◽  
pp. 391-395 ◽  
Author(s):  
S. Colliec Jouault ◽  
S. Mauray ◽  
J. Theveniaux ◽  
C. Sternberg ◽  
Boisson Vidal ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Subcutaneous Injection ◽  
Thrombin Generation ◽  
Sulfated Polysaccharides ◽  
Low Molecular Weight ◽  
High Molecular Weight Fraction ◽  
Antithrombotic Activity ◽  
Single Subcutaneous Injection ◽  
Chemical Structures

SummaryFucoidans (high-molecular-weight sulfated polysaccharides extracted from brown seaweeds) have anticoagulant and antithrombotic effects. They inhibit thrombin by catalyzing both serpins (antithrombin and heparin cofactor II) according to their chemical structures and origins. In this study, a low-molecular-weight (LMW) fucoidan of 8 kDa was obtained by chemical degradation of a high-molecular-weight fraction. The antithrombotic and anticoagulant activities of this new compound were compared to those of a low-molecular-weight heparin (LMWH), dalteparin, following subcutaneous administration to rabbits. This LMW fucoidan exhibited dose-related venous antithrombotic activity, with an ED80 of about 20 mg/kg, 2 h after a single subcutaneous injection. Its activity was comparable to that of dalteparin (close to 200 anti-Xa IU/kg) and was maximal 30 min after a single subcutaneous injection. The activity remained stable (about 70%) from 1 to 4 h after injection, but disappeared by 8 h. The antithrombotic activity was not associated with either a prolongation of the thrombin clotting time (TCT) or an increase in anti-Xa activity, contrary to dalteparin. A slight prolongation of APTT occurred with both compounds. This venous antithrombotic activity was associated with a decrease in ex vivo thrombin generation and with a significant increase in the lag phase in a thrombin generation test. LMW fucoidan thus has potent antithrombotic activity and a potentially weaker haemorrhagic effect (i.e. a smaller effect on coagulation tests and a smaller prolongation of the bleeding time) than dalteparin.

Sign in / Sign up

Export Citation Format

Share Document