Psychedelic Drugs Studied for Potential Role in Treating Pain

Anne Haddad

doi:10.1097/01.tpm.0000803084.66436.10

Psilocybin-assisted therapy for depression: How do we advance the field?

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867419888575 ◽

2019 ◽

Vol 54 (3) ◽

pp. 225-231 ◽

Cited By ~ 1

Author(s):

Sally E Meikle ◽

Paul Liknaitzky ◽

Susan L Rossell ◽

Margaret Ross ◽

Nigel Strauss ◽

...

Keyword(s):

Side Effects ◽

Adverse Effects ◽

Potential Role ◽

Treatment Options ◽

Clinical Environment ◽

Psychedelic Drugs ◽

Key Issues ◽

New Treatment ◽

Potential Use

In the quest for new treatment options for depression, attention is being paid to the potential role of psychedelic drugs. Psilocybin is of particular interest given its mechanism of action, its benefits in early trials and its relatively low side effects burden. This viewpoint outlines a number of key issues that remain to be elucidated about its potential use in the clinical environment, including clarification of the profile of people most likely to benefit and those who might experience adverse effects, longer-term outcomes and the role of psychotherapeutic input alongside the drug itself. There are also opportunities to understand better, the neurobiology underpinning its effects.

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POPDC proteins and cardiac function

Biochemical Society Transactions ◽

10.1042/bst20190249 ◽

2019 ◽

Vol 47 (5) ◽

pp. 1393-1404 ◽

Cited By ~ 4

Author(s):

Thomas Brand

Keyword(s):

Potential Role ◽

Striated Muscle ◽

Short Review ◽

Effector Proteins ◽

Muscle Disease ◽

Disease Genes ◽

Protein Protein Interaction ◽

Interaction Partners ◽

And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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The chemokines: their potential role in allergic inflammation

Clinical & Experimental Allergy ◽

10.1046/j.1365-2222.1996.d01-404.x ◽

1996 ◽

Vol 26 (9) ◽

pp. 1005-1019 ◽

Cited By ~ 1

Author(s):

L. M. TERAN ◽

D. E. DAVIES

Keyword(s):

Potential Role ◽

Allergic Inflammation

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Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1

Cardiovascular Research ◽

10.1016/s0008-6363(04)00177-4 ◽

2004 ◽

Author(s):

M CHEN

Keyword(s):

Cardiac Myocytes ◽

Potential Role ◽

Nuclear Translocation ◽

Oxidant Stress ◽

Apoptosis Inducing Factor

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1255: Potential Role of Postoperative Azotemia in Predicting Response to Interleukin-2 (IL-2) Immunotherapy Following Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)31469-1 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 414-414

Author(s):

John S. Lam ◽

Rakhee H. Gael ◽

Tobias Klatte ◽

Fairooz F. Kabbinavar ◽

Arie S. Belldegrun ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Potential Role ◽

Interleukin 2 ◽

Cytoreductive Nephrectomy

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The Effect of Path Length and Display Size on Memory for Spatial Information

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000137 ◽

2012 ◽

Vol 59 (3) ◽

pp. 147-152 ◽

Cited By ~ 11

Author(s):

Katherine Guérard ◽

Sébastien Tremblay

Keyword(s):

Path Length ◽

Potential Role ◽

Spatial Information ◽

Recall Performance ◽

Minor Role ◽

Length Effect ◽

Serial Memory ◽

Fixed Reference ◽

A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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